If Dutch cinema is examined in academic studies, the focus is usually on pre-war films or on documentaries, but the post-war fiction film has been sporadically addressed.

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

Through a range of case studies spanning the post-Cold War period in Iraq, Moldova and Serbia, this book studies asymmetric conflicts where warring sides exhibit vast power differentials.

Source: Nature Biotechnology, Volume 2014, Issue June (2014)

This thesis aims to develop model-based approaches to optimize drug dosing in patients with overweight and (morbid) obesity.

This book offers novel perspectives on the national and international dimensions of the post-war welfare state in Western Europe and North America.

The Revolt in The Netherlands erupted in 1566 and tore apart the Low Countries. In Memory Wars in the Low Countries, 1566-1700 Jasper van der Steen explains how public memories of the Revolt in the Habsburg Netherlands in the South and the Dutch Republic in the North diverged and became the objects…

Promotores: C.A.J. Knibbe; J.N. van den Anker, Co-promotores: H.P.A. van Dongen; B. van Ramshorst

From descriptive to physiological models that can predict oral absorption and elimination of CYP3A substrates across the pediatric age range.

Promotor: A.P.IJzerman Co-promotor: A. Bender

Promotor: B. van de Water

Tom Buitelaar is an Assistant Professor in the War, Peace & Justice programme of the Institute of Security and Global Affairs. This paper discusses four important challenges to the involvement of UN peace operations in international criminal justice: its effects on host state relations, peace and justice…

He’s a fast and animated speaker, which is only logical because Gerard van Westen is driving an express train. His destination? A virtual human, consisting of algorithms that predict what an administered substance will do in the body. The train is already a long way down the line and the pharmaceutical…

In this article, Ben de Jong, research fellow at the Institute of Security and Global Affairs, examines the relationship between double agents and their handlers.

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

The historiography of the Bretton Woods conference of July 1944 is dominated by the personal clash between the principal negotiators, Harry Dexter White of the United States and John Maynard Keynes of Britain.

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

In the last two decades, there have been heated public and scholarly debates in France, the United Kingdom, and the Netherlands on the violent end of empire. Nevertheless, the broader comparative investigations into colonial counterinsurgency tend to leave atrocities such as torture, execution, and…

Supervisor: Lizi Xia

Political scientist Corinna Jentzsch (Leiden University) about the organisation of rebel and government auxiliaries in the civil war in Mozambique (1976–1992).

The Afro-Asianism of the early Cold War has long remained buried under the narrative of Bandung, homogenising and subverting the different visions of post-colonial worldmaking that co-existed alongside the Bandung project.

Exploring the mechanism of targeted nanoparticle-mediated drug delivery using the zebrafish model

The path to rational drug and dose selection

Onderzoek van de onderzoeksgroep 'War, Peace and Justice'

The polypept(o)ide hybrid material attracted more and more attention over the past decade by combining the multifunctional characteristics of polypeptides with the shielding characteristics of polypeptoid-pSar possessing similar properties as a shielding material as polvethylene glycol(PEG). Polysarcosine…

Japan's Occupation of Java in the Second World War draws upon written and oral Japanese, Indonesian, Dutch and English-language sources to narrate the Japanese occupation of Java as a transnational intersection between two complex Asian societies, placing this narrative in a larger wartime context of…

Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)

Obesity may alter how a person absorbs, distributes, metabolizes or excretes medication. This thesis describes how obesity affects drug levels in the blood for antimicrobial agents, such as ciprofloxacin and fluconazole.

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

Source: Biosens Bioelectron, Volume 74, pp. 233-42 (2015)

With an emphasis on developing novel miktoarm star polymers termed PeptoMiktoStars, this thesis leverages asymmetric polymeric polypept(o)ide frameworks to advance their effectiveness in delivering hydrophobic drugs and nucleic acids.

Getting personal

Volume I of The Cambridge History of Strategy offers a history of the practice of strategy from the beginning of recorded history, to the late eighteenth century, from all parts of the world.

What dose of medicine do you give a child? That depends to a large extent on how quickly their kidneys remove the drug from the blood. For ethical reasons it is impossible to measure this directly in little patients. PhD candidate Sinziana Cristea combined different types of modelling and lots of data…

Who are open-source intelligence activists and how reliable are their contributions to public understanding of Russia’s war in Ukraine?

By the end of the sixteenth century, stories about the Revolt in the Low Countries (c. 1567-1648) had begun to spread throughout Europe. These stories had very different authors with very different intentions.

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

This edited volume by Jeff Fynn-Paul pushes forward the debate on the role of entrepreneurs in making war and building states in Europe and the Ottoman Empire.

On 17 August 1945, two days after the Japanese surrender that also brought an end to the Second World War in Asia, Indonesia declared its independence. The declaration was not recognized by the Netherlands, which resorted to force in its attempt to take control of the inevitable process of decolonization.…

Engin Kiliç defended his thesis on 11 june 2015

Investigating the relations between Tupi Indigenous Knowledge, Museum Collections and the Dutch Colonization of Brazil

This is the 2017 paperback release of William Michael Schmidli's The Fate of Freedom Elsewhere, which won the 2013 Foreign Affairs Magazine Best Book of the Year.

To what extent have the Dutch and British militaries learned from their counterinsurgency operations in southern Afghanistan between 2006 and 2020?

A new vision on the Revolt of the Low Countries through the eyes of Spanish commanders

This PhD project investigates how Russian state-aligned media frame the war in Ukraine for international audiences and how these frames travel across borders, being adopted, adapted, or challenged by foreign media and political actors.

The GMP Facility facilitates development and production of Advanced Therapy Medicinal Products (ATMPs) and chemical (peptide) synthesis.

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

It takes years to develop new medicines, from the test tube to trials in humans. During the process it often happens that a drug that seems promising in the initial stage has to be dropped in a later phase. This costs time and money. Leiden University and the LUMC are working closely together to make…

An overview of our infrastructure at the SPP division:

Subproject of