The Leiden University Medical Center (LUMC) is committed to improving healthcare and the health of individuals. The LUMC staff put this mission into practice on a daily basis with their leading research, cutting-edge teaching and optimal, innovative healthcare.

This thesis studies operator-algebraic aspects of subproduct systems, a generalization of product systems of Hilbert spaces.

The research of this programme is centered around dynamical systems, functional analysis, and their interplay.

In condensed matter systems electron-electron interactions, negligible in everyday metals, can dramatically alter the electronic behavior of the system. Examples of such altered behavior include high-temperature superconductivity and modulation of the electron density.

Thermodynamics is one of the founding scientific pillars that has helped us better understand heat engines, biology, ecosystems, and even black holes. While it fundamentally describes large systems by examining the bulk behavior of their constituents, it is anchored in the statistical equivalence of…

The ambition of the Medical Systems Biophysics and Bioengineering group led by Alireza Mashaghi is to develop and use physics and engineering concepts and tools for pathophysiology, diagnostics and therapy.

The research groups within the biological, soft and complex systems research area study the physics of a broad range of biological and soft materials. This spans both experimental and theoretical research.

On 12 September 2019, Judge Chile Eboe-Osuji, President of the International Criminal Court (ICC), delivered a lecture on Customary International Criminal Law and Head of State Immunity to open the academic year for the Advanced LL.M. Programmes in Public International Law & International Dispute Settlement…

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

Drug development critically depends on preclinical models that mimic human physiology, yet traditional two-dimensional cultures and animal models often lack predictive power.

Atherosclerosis is a chronic inflammatory disease, and vaccination may be an attractive method to induce long lasting protection against endogenous factors that contribute to the development of atherosclerosis. We have shown that for example vaccination against modified LDL or interleukin-12 limits…

Grammatical gender is famously the most puzzling of the grammatical categories. We have a solid typology of gender systems, yet exciting and unexpected patterns keep turning up which defy easy classification and straightforward analysis. Some of these question, stretch or threaten to cross the outer…

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

With cancer, a person’s body cells grow uncontrollably. Putting together a detailed picture of how this comes about makes it possible to develop efficient therapies. Researchers at the Leiden University Medical Centre (LUMC) and Leiden University are working together to gain a better understanding…

We study the physics of a broad range of biological and soft materials

This book explores the boundaries of the category of gender and their theoretical significance within the framework of Canonical Typology.

At Leiden University we believe it is important that you receive the right kind of support in your choice of study and while you study. This is why we use what we call the ‘Leiden study system’ to help you make a success of your study from start to finish.

Tuberculosis is a major global health problem caused by the Mycobacterium tuberculosis complex, claiming more than a million lives annually.

Exceptional collaboration between physicians is needed to better understand and treat autoimmune diseases that cause inflammation in various organ systems.

Researchers from Leiden University Medical Center (LUMC) have discovered how malaria parasites escape the immune system of mosquitoes. The so-called QC enzyme changes proteins on the outside of the malaria parasite such that the immune cells are unable to recognise the parasite. As a result, the parasite…

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

Leiden has a long history in the treatment of blood cell cancer. Research to find better therapies never stands still. One of the potential treatments currently being worked on is a ‘living medicine’.

DIGIFOOD is a transnational research project that investigates how data governance can support equitable and sustainable digital food systems. Around the world, digital technologies are transforming agriculture. Sensors in soil, satellites in space, and mobile phones in farmers’ hands are generating…

In her capacity as a lawyer and expert in International Humanitarian Law and Human Rights, Professor Helen Duffy is filing a lawsuit against the Dutch State. Leiden University’s weekly newspaper Mare reports that through her role, Duffy is assisting a Palestinian Dutchman whose family was killed in…

Promotor: S.M. Verduyn Lunel, Co-promotoren: M.F.E. de Jeu, S.D. Silvestrov

Research into research improves the academic system. CWTS studies and evaluates the academic system in various ways. One way is to provide information on the productivity and impact of academics by documenting how many publications they or their universities produce and how often these publications…

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

New and reemerging infectious diseases call for innovative and efficient control strategies of which fast vaccine design and development represent an important element.

All crested and marbled newts (the genus Triturus) suffer from an unusual genetic abnormality, called a balanced lethal system, that kills exactly half of their offspring. How can a trait so disadvantageous have survived millions of years of natural selection?

Vaccines are an extraordinary category of biopharmaceuticals. They are usually prophylactic and come in many types, from whole bacteria to peptides and nucleic acids. They are very cost effective and almost every human on the planet is vaccinated. The latter mandates that vaccines have to be extremely…

Is system thinking through perspectives the solution for biology education to help students see the connections between different topics?

Increasing above- and belowground biodiversity in arable leek cultivation to stimulate pest control by natural enemies.

In this article, Marco Cinelli, assistant professor at Leiden University College The Hague, examines proper and improper uses of Multiple Criteria Decision Analysis (MCDA) methods in energy systems analysis.

Would you like to know more about our research using laboratory animals or our studies on alternatives to animal testing? If so, take a look at the news articles on the right-hand side of the page (for mobile users, see the bottom of the page).

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.

Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.

This work has described synthetic strategies towards well-defined structures resembling capsular polysaccharide (CPS) fragments, CPS mimics, teichoic acid (TA) fragments as well as a third-generation ring-closing tandem metathesis (RCM) linker to better exploit the potential of automated synthesis.

Can we link multiple components from herbal extracts with their biological activities?

The symposium is open to all registered participants and consists of a one-day programme and a poster session.

The aim of the RAISE study is to investigate how resilient people respond to stress. Specifically, we will study how key biological systems (HPA-axis, immune system) interact with the brain and social environment in order to facilitate resilient functioning after childhood adversities.