Does a drug enter into the human brain once administered in the body?

Obesity may alter how a person absorbs, distributes, metabolizes or excretes medication. This thesis describes how obesity affects drug levels in the blood for antimicrobial agents, such as ciprofloxacin and fluconazole.

With an emphasis on developing novel miktoarm star polymers termed PeptoMiktoStars, this thesis leverages asymmetric polymeric polypept(o)ide frameworks to advance their effectiveness in delivering hydrophobic drugs and nucleic acids.

Volume I of The Cambridge History of Strategy offers a history of the practice of strategy from the beginning of recorded history, to the late eighteenth century, from all parts of the world.

Lecture

What dose of medicine do you give a child? That depends to a large extent on how quickly their kidneys remove the drug from the blood. For ethical reasons it is impossible to measure this directly in little patients. PhD candidate Sinziana Cristea combined different types of modelling and lots of data…

Who are open-source intelligence activists and how reliable are their contributions to public understanding of Russia’s war in Ukraine?

Getting personal

How do you ensure that a drug has an effect on the right protein – and nothing else? Chemist Anthe Janssen explored various methods for determining the selectivity of potential medicines. He also looked at the substance BIA 10-2474, after a man died in a French clinical trial in 2016. PhD defence on…

By the end of the sixteenth century, stories about the Revolt in the Low Countries (c. 1567-1648) had begun to spread throughout Europe. These stories had very different authors with very different intentions.

The Leiden University Institute for History is responsible for the main part of the historical research carried out at Leiden University. The institute has a wide-ranging academic scope.

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

On 17 August 1945, two days after the Japanese surrender that also brought an end to the Second World War in Asia, Indonesia declared its independence. The declaration was not recognized by the Netherlands, which resorted to force in its attempt to take control of the inevitable process of decolonization.…

This edited volume by Jeff Fynn-Paul pushes forward the debate on the role of entrepreneurs in making war and building states in Europe and the Ottoman Empire.

Engin Kiliç defended his thesis on 11 june 2015

Investigating the relations between Tupi Indigenous Knowledge, Museum Collections and the Dutch Colonization of Brazil

This is the 2017 paperback release of William Michael Schmidli's The Fate of Freedom Elsewhere, which won the 2013 Foreign Affairs Magazine Best Book of the Year.

To what extent have the Dutch and British militaries learned from their counterinsurgency operations in southern Afghanistan between 2006 and 2020?

A new vision on the Revolt of the Low Countries through the eyes of Spanish commanders

Developing new drugs is a difficult process. With the aid of artificial intelligence, Pharmaceutical scientist Xuhan Liu has developed methods that can help make drug design cheaper and faster. PhD defence on 15 February.

The GMP Facility facilitates development and production of Advanced Therapy Medicinal Products (ATMPs) and chemical (peptide) synthesis.

At high doses, drug candidate BIA 10-2474 binds not only to the protein that it targets, but to other proteins as well. It thus deactivates proteins that are involved in the metabolism of nerve cells. This is what an international group of researchers from Leiden University and Erasmus MC, among others,…

Lecture, Seventh Annual Austrian Studies Lecture

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

Subproject of

It takes years to develop new medicines, from the test tube to trials in humans. During the process it often happens that a drug that seems promising in the initial stage has to be dropped in a later phase. This costs time and money. Leiden University and the LUMC are working closely together to make…

In Reframing the Diplomat Albertine Bloemendal offers a unique window onto the unofficial dimension of Cold War transatlantic relations by analyzing the diplomatic role of the Dutch Atlanticist Ernst van der Beugel as a government official and as a private diplomat.

The territories that would make up what is today the Republic of Zambia officially became British in 1891. However, this did not equate to an on-the-ground presence of colonial authority capable of affecting the destiny and daily lives of people.

An overview of our infrastructure at the SPP division:

Leiden researchers, led by Sebastian Pomplun developed a new method to screen hundreds of thousands of molecules for drug discovery, using mass spectrometry instead of DNA tags. ‘We wanted to make drug discovery faster and more accessible.’

In this chapter, Linde Desmaele & Luis Simón examine NATO’s strategic adaptation since Russia’s annexation of Crimea in 2014.

This book explores the reception of foreign news during the late sixteenth-century civil wars in France and the Netherlands.

Microscopic insight on lipid-based nanomedicine in vivo remains limited to the perception of the knowledge that could be obtained: if we interpret only what we see, then we only believe to know. Although believing to know encapsulates an undefined amount of uncertainty in the exploration of lipid-based…

Japan's Occupation of Java in the Second World War draws upon written and oral Japanese, Indonesian, Dutch and English-language sources to narrate the Japanese occupation of Java as a transnational intersection between two complex Asian societies, placing this narrative in a larger wartime context of…

Does foreign aid promote human rights?

Robert Pee, William Michael Schmidli (Eds.) This book posits that democracy promotion played a key role in the Reagan administration’s Cold War foreign policy.

Lecture, European Union Seminar / CHEI Seminar

Lecture | Leiden Lectures on Arabic Language & Culture

Potential drugs that seem promising in the lab, but don’t show any activity in a person: they cost the industry an incredible amount of time and money. That’s why Indira Nederpelt focuses on a more efficient search for new drugs in her PhD, by determining the kinetics of a potential drug earlier on…

Laura Heitman has been awarded a VIDI grant for her innovative drug research. Heitman strives to optimize a drug’s binding kinetics at its target in order to ultimately fight diseases effectively. She even pleads for a paradigm shift in drug discovery.

Film screening

Currently, more than 80% of drugs are used in an off-label manner in critically ill neonates.

In this article, Thomas Maguire, assistant professor at the Institute of Governance and Global Affairs, examines the intelligence of the US, British and Ukrainian governments and NATO partners concerning Russia and its war against Ukraine. This article discusses how and why governments communicate intelligence…

Oncode Investigator Mario van der Stelt and his colleagues have discovered a new potential drug that suppresses chemotherapy induced neuropathic pain.

On 4 May, Leiden University remembered the victims of the Second World War from our university community. Alumni, students and present and former staff of the University came together for this Hour of Remembrance.

Emily Wolff, PhD candidate at Leiden University, wrote a paper about the inclusion of imperial citizens in the Dutch post-war welfare state.

Southern Crossings: Indian activists and the Afro-Asian movement in the early Cold War era

In the search for new medicines against diseases such as cancer, a Leiden team has developed a new workflow. This approach combines artificial intelligence (AI) with molecular modelling and is suitable for finding unknown and innovative drug structures, the researchers proved.