High-throughput holistic preclinical screens are increasingly used in drug discovery, to assess both drug efficacy and drug safety.

Investigating the making of knowledge in anthropology and natural history in colonial and postcolonial Indonesia.

In this thesis, I investigated the neurogenetic properties of Neotropical bat species. Bats represent the second largest mammalian order (Chiroptera) in the world, with Neotropical bats constituting about 13% of the total number of bat species.

The subject areas covered encompass functional genomics, signal transduction, cellular differentiation, development, host-microbe interactions and animal behaviour.

Speech Prosody 2024 includes three workshops.

How can we organise society so as to keep our planet habitable for us and for all other life forms around us? To answer this question, Leiden researchers collaborate across disciplines, from biology to data science, and from environmental economy to archaeology.

The IBL's staff participates in the various boards, councils and associations, where they meet and exchange ideas on the continuous institute's improvement.

A novel in vivo model system for studies on glucocorticoid resistance

The goal of hit and lead optimization is to optimize suitable chemical starting points that can modulate a drug target. The methods and technologies used are similar to those in Hit Discovery, but once the compound has shown activity in an animal model, it moves from 'hit' to 'lead.'

A radical reduction in the amount of meat, dairy and other products sourced from animals is possible in the coming decades, as people turn to an increasing variety of alternatives. This would unlock vast amounts of land that we could use to produce energy and remove carbon from the atmosphere. Leiden…

Coral reefs throughout the world are under threat. After studying the reefs in Malaysia, Zarinah Waheed concluded that there is room for improvement in coral reef conservation. PhD defence 22 November.

How can we make the information in handwritten historical research reports accessible and searchable? Data scientists at Leiden University are working with other universities on a method that will improve access to cultural heritage.

Key publications of the Predictive Pharmacology group.

Our leadership model consists of four competences that align with our core values. Each leadership competence expresses two opposing qualities. The goal is not to prioritise one of these qualities over the other, but to find the right balance between them. Effective leadership starts with awareness…

Target selectivity is an important aspect of any drug molecule, and certainly a parameter to be optimized. That is not trivial for a number of reasons. First of all hundreds of drug targets (receptors, enzymes, ion channels) exist, and no single lab in the world has assays for all of them.

The Faculty of Science

Microbes influence and respond to other organisms. This theme explores the dynamic relationships within plant and animal microbiomes, and the immune responses that govern host defense. Using model systems such as zebrafish, insects, and plants, we investigate fundamental processes and engineer microbes…

What are key regulators of plant ageing that can reverse ageing in plants (rejuvenation), and how can we use this knowledge to improve crop plants?

Do offshore windfarms affect the local biodiversity of the pelagic fish community and are fish deterred or attracted by sounds?

What are the host immune defence mechanisms that control intracellular infections and how are these subverted by pathogens?

What was the environmental impact of the industrial mining revolution that transformed southern Africa? Specifically, what was the impact of industrial mining when viewed from a more than human multi-species perspective?

The Creative Intelligence & Technology master's programme (previously Media Technology) at Leiden University focuses on creative exploration as well as the understanding of science and technology.

Within the Global Ethnography specialisation, you can develop your own research project or make use of the research opportunities offered by our staff members listed below.

Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.

This catalogue is the result of the EU_CUL project (2018-2021), which explores the use of cultural heritage in Europe for fostering academic teaching and social responsibility in higher education.

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn, Co-promotor: Dr. M.J.M. Schaaf

Patterns of paleomobility in the Caribbean were studied through an inter-disciplinary approach using a combination of archaeological, osteological, mortuary, and isotopic data.

Promotor: Prof.dr. M.K. Richardson

An archaeological case-study of the Pointe des Châteaux, La Désirade and Les Îles de la Petite Terre micro-region, Guadeloupe, F.W.I.

The effects of anthropogenic noise on interactions between predators and their prey are still little understood.

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

Environmental Humanities in the New Himalayas: Symbiotic Indigeneity, Commoning, Sustainability showcases how the eco-geological creativity of the earth is integrally woven into the landforms, cultures, and cosmovisions of modern Himalayan communities.

Ecotox is located in an ambitious surrounding at the Leiden University. It is an initiative of both institutes Institute of Environmental Sciences (CML) and Institute of Biology Leiden (IBL).

Promotor: E.F. Smets Co-promotor: J. Geml

The external tissues of plants and animals are colonized by microbial communities termed microbiota. When organisms are exposed to environmental pollutants, these substances will therefore encounter microbiota at the exposure interface.

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk

The explosive radiation and diversification of the advanced snakes (superfamily Colubroidea) was associated with changes in all aspects of the shared venom system. Morphological changes included the partitioning of the mixed ancestral glands into two discrete glands devoted for production of venom ormucous…

Pursuing Whiteness in the Colonies offers a new comprehension of colonial history from below by taking remnants of individual agencies from a whiteness studies perspective. It highlights the experiences and perceptions of colonisers and how they portrayed and re-interpreted their identities in Afric…

A study on the utilisation of Iron Age rectangular structures and related depositional practices in the Low Countries

Observational, cognitive and physiological measurements in social contexts.