A group of confidants including a former student of Meijers managed to avert his deportation to a death camp. In her lecture on 27 November, Cleveringa Professor Marjan Schwegman revealed the history of the persecution of the Jewish Professor Eduard Meijers.

Bioprinters that enable scientists to engineer complex tissues and organs. It sounds like science-fiction, but not for the scientists of the Alireza Mashaghi lab at the Leiden Academic Centre for Drug Research. The lab has recently been equipped with two state-of-the-art bioprinters: BioX and LumenX+.…

Nowadays, it is almost impossible to imagine warfare without unmanned aerial vehicles, or drones. For instance, they have been deployed in the war in Iraq and Afghanistan. Are the current laws of war adequate to address the use of drones? PhD candidate James Welch will defend his thesis on 21 March.

After a year of war against Ukraine, professors André Gerrits, Antoaneta Dimitrova and Frans Osinga look back at Russian aggression and Western unity and ahead to the new offensive.

This thesis focuses on enhancing predictions of central nervous system drug exposure using the LeiCNS-PK3.0, a physiologically based pharmacokinetic model.

Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.

Discovering effective new drugs is a long, expensive and uncertain process. Laura Heitman wants to improve this by finding out more about how drugs bind to proteins that play a role in disease. She calls it ‘drug discovery 3.0’. Inaugural lecture on 9 December.

Light can be used to apply forces on single cells. Focused lasers have been used by physicists to tweeze particles and to manipulate them. These so called “optical tweezers” can be used as mechanical phenotyping tools for characterising the mechanics of materials and living objects.

PhD candidate Dennis Wander searches for the best of both worlds. That is to say: a cancer drug that is effective and also has minimal side effects. To this end, he makes new molecules inspired by two existing medicines. And not without result: ‘We have created a new variant that is very promising.’…

Promotor: M. Danhof, Co-promotores: J. Freijer, A. Yassen

Sugar excipients, needed to stabilize medicines, can be unsafe for patients due to an impurity discovered recently by Daniel Weinbuch. ‘The biopharmaceutical industry should now consider new excipient quality criteria for safer drug development,’ he says. PhD defence on 13 December.

Volume II of The Cambridge History of Strategy focuses on the practice of strategy from 1800 to the present day.

Drawing on the analogical lessons of the Great War, this article uses applied history to analyze how the four parallels discerned can help us make sense of contemporary Sino-American rivalry

Archives were a common target during the Second World War, and hundreds suffered damages. Among these archival losses, the losses to medieval manuscript collections stand out.

This week 'Dutch Post-war Fiction Film through a Lens of Psychoanalysis' by Peter Verstraten was published by Amsterdam University Press, the sequel to Humor and Irony in Dutch Post-war Fiction Film from 2016. Each chapter in his 482-page new study begins with a title of Fons Rademakers who made films…

This paper written by Alexandre Afonso, Assistant Professor and Researcher at Leiden University, argues that gender norms and the political strength of the left were important structuring factors regarding why European countries choose migrant labour to expand their labour force in the decades that…

This book presents an introductory survey of the major themes, thinkers and texts, philosophical genres and profound insights of the Chinese philosophical tradition. Its coverage ranges from the foundational history of Chinese thought in the 6th–5th centuries BCE up to the present day.

This interdisciplinary study focuses on (trans)national ethnic and popular networks, combining historical-ethnographic and computational methods to understand the ‘workings’ of networked conflict interfering in the increasingly violent conflict in the Sahel (Africa) and beyond. The project focuses on…

Do medicines arrive in the right amount at the right spot in our brain? By making a model that depicts our brain in small 'brain blocks', Esmée Vendel tries to find an answer to this question. Her new, mathematical model predicts the concentration of medicines in the brain over time and space. Vendel…

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot

As of April 1, 2018, Erik Danen has been appointed as Professor of Cancer drug target discovery at the Leiden Academic Centre for Drug Research (LACDR). His discipline is cell biology of cancer, in which he focuses on the mechanisms underlying metastasis and therapy resistance.

On Wednesday 9 March, a Faculty meeting about the war in Ukraine was held for staff and students in the Lorentz Lecture Hall. By the time the meeting started at 17.00 hrs, the 220 available seats in the lecture hall had been filled mainly by large numbers of students.

On Friday, November 17, 2017, Assistant Professor Jens Iverson provided the Keynote for the annual symposium by the Minnesota Journal of International Law: Jus Post Bellum: Justice After the War.

The aim of this work was to study the applicability of antigen-coated pH-sensitive microneedle arrays for effective vaccination strategies. Therefore, a model antigen (ovalbumin) was coated onto pH-sensitive (pyridine-modified) microneedle arrays to test pH-triggered antigen release by applying the…

Conceptualizing ceasefires as bargaining instruments challenges established ideas about the processes that lead up to conflict settlement, and about war re-emergence, with important implications for our understanding of war and peace.

Adopting a largely chronological approach, Gerrits links the historiography of post-war Europe and the major theoretical approaches to nationalism with analysis of key historical developments and events.

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

In an essay published in three prominent European newspapers, Professor Luuk van Middelaar takes a close look at Europe’s role in the Russian invasion of Ukraine. ‘Europe shows plenty of political energy, but what is still lacking is strategic cool-headedness, in facing a nuclear power.’

This thesis tackles the difficulty of predicting the liver’s clinical response to novel therapies, a challenge arising from interspecies differences and limitations of existing in vitro models.

International pharmaceuticals company Grünenthal is to open an innovation hub on the Leiden Bio Science Park. The hub will make it easier for scientists and drug developers to work together.

Promotor: B. van de Water

In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.

Starting January 18, the online exhibition Images of the Indonesian War of Independence, 1945-1949 can be viewed via the UBL website. The exhibition is the result of a collaboration between the Royal Netherlands Institute of Southeast Asian and Caribbean Studies (KITLV) and Leiden University Libraries…

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

Promotor: M. Ubbink, Co-promotor: G. Siegal

Promotores: A.P. IJzerman, H.W.T. van Vlijmen

The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

Simon Willmetts provides evidence for systematic policy of direct collussion between the TIme Inc. media empire and U.S. Central Intelligence Agency.

Promotor: Prof.dr. R. Verpoorte, , Co-Promotor: Young Hae Choi

Denying war crimes and genocide is prohibited by law in the Netherlands. Minimising international crimes can also have far-reaching consequences, warns Marloes van Noorloos, Professor of Criminal Law and Criminal Procedure, in Trouw newspaper.