In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

By 2050, more than 70 per cent of the world’s population will live in cities. A group of International researchers has developed software that shows city planners where to invest in nature to improve people’s lives and save billions of dollars.

In dermatology, there should be a high level of multidisciplinary collaboration among institutes and specialists, Professor of Translational Dermatology, Robert Rissmann, will say in his inaugural lecture on 8 July. He is building an infrastructure that will put pre-clinical and clinical skin research…

Two Leiden researchers have been awarded ERC Proof of Concept grants. These grants, each worth EUR 150,000, will help the grantees in their efforts to bridge the gap from basic science to real-life applications

As of 1 November, Laura Heitman has been appointed full Professor of Molecular Pharmacology at the Leiden Academic Centre for Drug Research (LACDR). Heitman has been working on the understanding and improvement of drug-receptor interactions in early drug discovery. ‘My ultimate aim is to make medicines…

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

Promotor: E. Bouwman, Co-promotor: S. Bonnet

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

Drug development critically depends on preclinical models that mimic human physiology, yet traditional two-dimensional cultures and animal models often lack predictive power.

A breakthrough from the PhD research of medical chemist Elmer Maurits may help patients with autoimmune diseases and blood cancer in the future. But bringing a discovery from the lab to the clinic is not so easily done. Thanks to NWO's Venture Challenge, Maurits and his team will receive ten weeks of…

The information below concerns courses that our group teaches in Leiden. 

Learn to program, gain knowledge of AI methods, or use it in a research project at the LACDR. With the introduction of the innovative digital learning environment ‘Digital Labcoat’, Biopharmaceutical Sciences bachelor students can further develop their computational skills.

Research and design are two activities that are becoming increasingly important in the Dutch subjects O&O (‘research and design’) and NLT ('nature, life and technology’). The dissertation of Tessa Vossen (ICLON and Faculty of Science) indicates that teachers and students understand the importance of…

In the search for sustainable energy solutions, the idea of artificial photosynthesis has been proposed as an approach with which to use water and sunlight to produce hydrogen.

How can we make clever use of new technologies to improve quality of life in cities? The answer is in the NL Smart City Strategy, which Mark Rutte officially received on January 25th. Three professors from Leiden University - Carolien Rieffe, Joost Kok and Wessel Kraaij - gave advice.

The AtheroNeth consortium received €6 million from the Dutch Heart Foundation to gain a better understanding of the differences in disease progression among patients with atherosclerosis. The ultimate goal is to enable personalised treatment.

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

You are warmly invited to join us for the second meeting of the KABK Design / Research Club, a forum for researchers from the KABK and Leiden University who are conducting research in, about, or through design-related disciplines.

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

On Saturday November 16 Alice Twemlow was awarded the Simon Mari Pruys prize for design criticism for her essay ‘Conflicting Definitions of Key Terms’.

Organized by the Lectorate Design Friday, December 14, 2018 KABK Auditorium 10:00-17:00

Gerard van Westen and his group, together with pharmaceutical company Galapagos, start on developing software that invents new effective molecules. They will receive an NWO LIFT grant of 280,000 euros, of which 63,000 euros will come from Galapagos. The company will also bring its expertise in biology,…

In a project of INSOL Europe's Turnaround Wing, TRI Leiden is working on the design of Principles and Guidelines for Restructuring and Turnaround Professional. These Principles and Guidelines are designed for the out-of-court turnaround of a business in distress. This Report is the result of a study…

The design for the METIS instrument for the Extremely Large Telescope (ELT) is final. The European Southern Observatory (ESO) has given the green light for production of all parts of the instrument. It is the first ELT instrument, designed and to be built under Dutch leadership, to formally pass the…

In the research programme Microbial Sciences we perform state-of-the-art research in the field of biotechnology and microbial sciences.

Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

Future users of the Aleida Nijland building were recently the first to have the opportunity to admire the design plan for the new building. During a user meeting, architectural firm De Zwarte Hond presented the design, and future users of the building were able to share their wishes and ideas for further…

Eduard Fosch-Villaronga from eLaw - Center for Law and Digital Technologies, and Hadassah Drukarch, explored the role of intersectionality within (rehabilitation) robot design, testbed, and standards. Being oblivious to these considerations may give way to the development of robots that fall short of…

Researchers of the Leiden University Medical Centre (LUMC) and the Leiden Institute of Chemistry have made an important discovery about the commonly used anti-cancer drug doxorubicin. They have found a way to reduce its side effects without sacrificing the effectiveness of the medication. This is encouraging…

The research study presented in this dissertation focuses on issues pertaining to the reliability, generalizability, and validity of authentic performance assessments of teachers.

Synthetic methodlogy is described, aiding in the synthetic preparation of putative inhibitors of retaining and inverting glycosidases and glycosyl transferases. All constructs are cyclophellitol-based cyclitols.

This year Elke Devroe and Moniek Akerboom organized a ‘Research Design Conference’ for students in the course ‘Research Design’ of the Master’s Crisis and Security Management (CSM). Each group competed in obtaining a (fictive) grant. Students learned to defend their proposal and make it attractive and…

Research in the POD-group addresses all features of random phenomena – modelling, structuring, analysis, control, optimisation – and covers both fundamental and applied aspects.

The future does not yet exist, but many people think about it daily. The course Designing Your Future, part of the Honours Programme at the Faculty of Governance and Global Affairs and taught by Bram Hoonhout‘Being a mentor during HOP week is something I can recommend to everyone’

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

Not experiments and lab coats, but computers and artificial intelligence: this year's Nobel Prize in Chemistry went to the inventors of the groundbreaking AI model, AlphaFold. This programme accurately predicts protein structures based on their genetic code—a crucial step in understanding biological…

Leiden researchers, led by Sebastian Pomplun developed a new method to screen hundreds of thousands of molecules for drug discovery, using mass spectrometry instead of DNA tags. ‘We wanted to make drug discovery faster and more accessible.’

A team of five PhD students from Leiden University is in the running for first prize in the Pharmacometrics Skills Competition. In a drug development simulation, they apply their mathematical pharmacological skills to solve clinical problems. On 24 March they will compete in the finals in Orlando, F…