A high-end label: Cyclophellitol aziridine-type activity-based probes allow for ultra-sensitive visualization of mammalian β-glucosidases (GBA1, GBA2, GBA3, and LPH) as well as several non-mammalian β-glucosidases (see picture). These probes offer new ways to study β-exoglucosidases, and configurational…

Three at the same time: a ligation strategy combining tetrazine–norbornene cycloaddition, Staudinger–Bertozzi ligation, and copper(I)-catalyzed click reaction was used to label the three catalytic activities of the proteasome simultaneously in a single experiment. The orthogonality of the three ligation…

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Plants, algae and cyanobacteria have the amazing capacity to perform delicate photophysical and photochemical processes of light capture, excitation transfer, charge separation and catalysis in fluctuating living environments. As a consequence, photosynthetic proteins and membranes form dynamic architectures.…

Huub de Groot is professor in Biophysical Organic Chemistry. With his team he works in the field of photosynthesis and artificial photosynthesis. The molecular basis for photosynthesis is formed by protein complexes and organelles that contain chlorophyll molecules. The antenna systems herein capture…

The chemical industry must continue to innovate for a more sustainable, healthier society. The reseachers from the Leiden Institute of Chemistry (LIC) contribute by applying their knowledge to themes such as sustainability, energy and health.

The overlapping of intergovernmental organizations sharing Member States is one of the key challenges for achieving effective regional integration.

Buitelaar argues that IOs micro-level discourse adapts imperfectly to macro-level changes, balancing adaptation to pressures with commitment to values.

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

Thomas Hansen is the recipient of the 2020 KNCV-Backer Prize for best organic chemistry thesis in the Netherlands.

Thesis focused on uncovering the underlying mechanisms of the lysosomal storage disorders Gaucher's disease using chemical tools, biochemical assays and lipidomics.

An interdisciplinary team of Leiden researchers has discovered that wasting syndrome, a severe byproduct of tuberculosis, is the same for all humans and animals studied. The discovery offers new opportunities to investigate the still insufficiently understood condition. The scientists also developed…

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

On January 11, 2025, our esteemed colleague and emeritus professor Arne van der Gen passed away. Arne was a professor of Organic Chemistry from 1980 until his retirement in 2000, and was a great advocate of the integration and harmonization of European education in chemistry. Arne was 90 years old.

Research projects for students of the University of Leiden and other Dutch Universities are often available at the MacBio group. The research lines are also described in the Research section. For details of specific projects contact the supervisor (Ubbink, Dame, Boyle, Jeuken or Wentink).

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.

As part of the events to mark the 100th anniversary of the International Labour Organization, the Department of Labour Law of Leiden University has organized a film evening together with Kijkhuis cinema in Leiden.

In a promotional video for the SUNRISE initiative, prof. Huub de Groot explains the impact and ideas behind artificial photosynthesis.

On Friday 10 July the Towards Biosolar Cells research programme was granted a budget of 25 million euros by the Dutch Government. The Ministry of Agriculture, Nature and Food Quality recommended the programme because it will contribute to green energy, improve food supplies and a create a more sustainable…

This thesis describes research aimed at discovering inhibitors selective for either of the two endoplasmic reticulum α-glucosidases, ER-I and ER-II, with the overarching goal of discovering new antiviral agents to treat viruses that rely on host N-glycosylation for proliferation.

Researchers at Leiden University have been awarded a €4 million EU grant to develop climate-neutral fuels. With this money they will expand the broad research community that focuses on green energy. If we work together, we can make the rapid progress that is needed, says Prof. Huub de Groot, Professor…

The Organ Art of the first female German concert organist and Bremen Cathedral organist and

The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

This thesis describes the design and synthesis of novel small molecules based on sulfur-containing heterocycles for the inhibition of glycosidases and glycosyltransferases related to Fabry and Pompe disease.

Anthe Janssen graduated ‘summa cum laude’ for the master’s programme Chemistry.He used NMR methods to gain insight in the syntheses and behavior of bio sugars. With this knowledge future therapeutics and research tools in hemical and medicinal biology can be developed. Anthe was awarded € 2.500.

The fastest chemical reaction in the universe takes place inside our eyes.

This year, the International Institute of Air and Space Law (IIASL) attended the first days of the 41st Assembly of the International Civil Aviation Organization (ICAO).