Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.

Exploring the mechanism of targeted nanoparticle-mediated drug delivery using the zebrafish model

The path to rational drug and dose selection

Beginning teachers often experience difficulties making activating lessons. This study investigates how and if the practical teaching model can offer them a hand in learning to design lessons.

NWO awarded a grant for novel research on Complex and Distributed Cyber-Physical Systems (CPS). The grant will fund a four-year research project in which they hope to devise a method to explore and find optimal designs for CPS. Todor Stefanov, Associate Professor at the Leiden Institute of Advanced…

Atherosclerosis is a chronic inflammatory disease affecting millions of people world-wide.

This thesis describes the design, synthesis, and immunological evaluation of varying (neo)antigenic peptide conjugates containing either a TLR2 or a TLR7 agonist.

Research and design are two activities that are becoming increasingly important in the Dutch subjects O&O (‘research and design’) and NLT ('nature, life and technology’). The dissertation of Tessa Vossen (ICLON and Faculty of Science) indicates that teachers and students understand the importance of…

Laura Heitman has been awarded a VIDI grant for her innovative drug research. Heitman strives to optimize a drug’s binding kinetics at its target in order to ultimately fight diseases effectively. She even pleads for a paradigm shift in drug discovery.

Didactics

The polypept(o)ide hybrid material attracted more and more attention over the past decade by combining the multifunctional characteristics of polypeptides with the shielding characteristics of polypeptoid-pSar possessing similar properties as a shielding material as polvethylene glycol(PEG). Polysarcosine…

We aim to create an innovative e-learning and virtual reality training that helps healthcare providers to optimize placebo effects and minimizes nocebo effects via their communication.

The kidneys play a major role in the elimination of drugs. In children, the exact age-related physiological changes underlying kidney function remain largely unknown.

The Automated Design and Analysis of Algorithms (ADA) research group pursues the development of Artificial Intelligence techniques that complement, rather than replace, human intelligence.

Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)

Promotors: Prof.dr. T.H.W. Bäck, Prof.dr. B. Sendhoff (Technische Universität Darmstadt)

Tuberculosis is an infectious disease which is spreaded through the air. It is caused by Mycobacterium tuberculosis and it led 1.7 million people to death in 2016. This mortarlity rate is concentrated in developing countries such as Indonesia, Philippines, Pakistan, and South Africa. These numbers make…

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

PhD defence

PhD defence

Bruno Munari (1907–1998) was a prolific and influential artist, designer, and writer. Alessandro Colizzi’s study is the first extensive, detailed record of Munari’s graphic design production, and as such provides a substantial base for a full understanding of his oeuvre.

With an emphasis on developing novel miktoarm star polymers termed PeptoMiktoStars, this thesis leverages asymmetric polymeric polypept(o)ide frameworks to advance their effectiveness in delivering hydrophobic drugs and nucleic acids.

Errors are everywhere, and mechanical failures are especially common: buckled grain silos and cracked support columns are, justly, seen as an issue to be avoided.

Promotor: M. Danhof, Co-promotores: J. Freijer, A. Yassen

This doctoral research project in design seeks to shed a light on legibility in the context of visually impaired beginning readers.

The aim of current study was to develop a dried inactivated polio vaccine (IPV) formulation with minimal loss during the drying process and improved stability when compared with the conventional liquid IPV.

In the search for new medicines against diseases such as cancer, a Leiden team has developed a new workflow. This approach combines artificial intelligence (AI) with molecular modelling and is suitable for finding unknown and innovative drug structures, the researchers proved.

How do you ensure that a drug has an effect on the right protein – and nothing else? Chemist Anthe Janssen explored various methods for determining the selectivity of potential medicines. He also looked at the substance BIA 10-2474, after a man died in a French clinical trial in 2016. PhD defence on…

To design the ideal water oxidation catalyst, understanding of the catalytic mechanism and decomposition pathways is essential.

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

The authors systematically search and review relevant definitions of Security by Design (SbD) in comparison with Privacy by Design (PbD).

This thesis focuses on enhancing predictions of central nervous system drug exposure using the LeiCNS-PK3.0, a physiologically based pharmacokinetic model.

His article on ‘the War on Drugs’ in Colombia and the Philippines has been in the top five most downloaded articles of Oxford University Press for some time. Now, Assistant Professor Santino Regilme is to receive a NIAS grant to map out the global war on drugs.

Huda Abi-Fares defended her thesis on 10 January 2017.

Promoter: J.G.E.M.Fraaije, Co-promotor: A. Kros

Didactics

Higher design and engineering educators have different views on what a new or renewed curriculum should entail, content-wise as well as pedagogically. This research aims to describe how these ‘curriculum perspective perceptions’ influence working definitions, end goal formulation, and the scope of results…

Currently, several successful vaccines are available. However, for pathogens with a highly variable genetic composition, and for which serum IgG antibodies are not a useful correlate of protection, effective vaccines are yet to be developed.

How can the concept of Critical Making be expanded into a general approach that ties the critical methodology of artistic research, and the established concepts of artistic autonomy, together with contemporary creative-technological development?

The central issue of this research concerns how students can best be supported in their study choice, study career and future orientation with a view to flexible entry and transitions and perspective in education and work.

Developing new drugs is a difficult process. With the aid of artificial intelligence, Pharmaceutical scientist Xuhan Liu has developed methods that can help make drug design cheaper and faster. PhD defence on 15 February.

The GMP Facility facilitates development and production of Advanced Therapy Medicinal Products (ATMPs) and chemical (peptide) synthesis.

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

Promotores: J. Kok, M. Chaudron (Chalmers University)

The coronavirus has the world in its grip. Finding a cure has never been more important. Unfortunately, the development of new drugs for treatment of the COVID-19 disease caused by the virus and development of a vaccine are complex, lengthy, and above all costly processes. With the help of computer…

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency