The main question addressed in this thesis is how we can best conceive the contrast between a priori and empirical truths.

PhD defence

The project will support Responsible, Research and Innovation (RRI) policy experiments in the healthcare sector in three European territories: in Murcia (ES), Örebro (SE) and the Republic of Cyprus (CY). CHERRIES will engage the territorial stakeholder ecosystems in participatory agenda setting, need…

The aim of this project is to explore the use of statistical interaction models to quantify cross-omics and omics-drug interactions in large-scale clinical and experimental datasets

Pancreatic ductal adenocarcinoma (PDAC) is the deadliest common cancer, with only 8% of patients surviving for five years. One reason for this poor outcome is that current chemotherapy treatments are highly toxic, often leaving patients too sick to receive treatment or forcing doctors to lower the dose…

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

Promotores: Wim Jiskoot; Ferry Ossendorp

Emotions play a key role in EU politics. This article examines how emotions influence the EU’s response to international crises and norm violations.

This catalogue is the result of the EU_CUL project (2018-2021), which explores the use of cultural heritage in Europe for fostering academic teaching and social responsibility in higher education.

Promotor: Prof.dr. W.J.G.M. Peijnenburg, Co-promotor: Dr. ing. M.G. Vijver

Voting Advice Applications represent popular election campaign tools in many countries, enabling voters to discover which party or candidate provides the best match with their political preferences. Political scientists Martin Rosema (University of Twente) and Tom Louwerse (Leiden University) examine…

International trade has played a major role in defining the modern global economy. Trade, however, entangles the environmental pressures of economic sectors, giving the illusion of environmental improvements, while the opposite may be occurring.

Emerging from the first wave relatively unscarred to an increase in infections. This research analyses the response from the Bulgarian government to Covid-19.

PhD defence

PhD defence

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

On 7 May 2020, Jolanda van der Vliet defended her thesis 'The International Legal Protection of Environmental Refugees. A human rights-based, security and State responsibility approach'. The doctoral research was supervised by Prof. N.J. Schrijver and Prof. J.J.C. Voorhoeve.

Researchers and clinicians at Leiden University Medical Centre (LUMC) are about to begin a milestone clinical study. It will be the first time a stem cell gene therapy developed in the Netherlands is used in a clinic. The therapy will be used to treat children with SCID, a rare disorder where children…

Across Europe, the need for a more dynamic governance and a better societal integration of research and innovation is increasingly appreciated. Internal drivers of change (such as the digitalization of science) and political will to better align with societal needs and concerns are bringing about aspirational…

Up to 50% of all children and adolescents growing up worldwide are exposed to at least one form of childhood adversity (CA), which is one of the strongest predictors for later-life psychopathology.

As robotics advances in the field of emergency response, firefighting robots – or 'firebots' – offer promising improvements in safety and operational efficiency. However, to ensure these technologies truly benefit society, non-technological factors must be considered from the outset.

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

Can the conditioning paradigm be used for checkpoint inhibition cancer treatment?

This article examines to what extent bureaucratic responsiveness depends upon the source, the content and the salience.

A combination of two potential drugs gives hope of a 'super blockage' of an over-active immune system, Leiden researchers report in Nature. The breakthrough came from the crystallisation of a membrane protein.

New and reemerging infectious diseases call for innovative and efficient control strategies of which fast vaccine design and development represent an important element.

Corneal transplantation is one of the most common human organ transplantations worldwide. Although the 1-year survival rate is as high as 90%, more than half of transplantation patients suffer various types of corneal rejection, such as epithelial rejection, chronic stromal rejection, and endothelial…

On Wednesday 13 December, Melanie Fink will defend her doctoral thesis ‘Frontex and Human Rights: Responsibility in “Multi-Actor Situations” under the ECHR and EU Public Liability Law’. The defence will take place at 10.00 hrs at the Academy Building of Leiden University, Rapenburg 73. The supervisors…

Researchers from Leiden University Medical Center (LUMC) have discovered how malaria parasites escape the immune system of mosquitoes. The so-called QC enzyme changes proteins on the outside of the malaria parasite such that the immune cells are unable to recognise the parasite. As a result, the parasite…

PhD defence

The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.

Microneedle-based vaccination has several advantages over vaccination by using conventional hypodermic needles.

Leiden has a long history in the treatment of blood cell cancer. Research to find better therapies never stands still. One of the potential treatments currently being worked on is a ‘living medicine’.

Treatment with special stem cells seems to be a good option for suppressing the immune system in organ transplants. Researchers are trying to learn from processes that take place in the human body during pregnancy.

How do plant defense genes get activated?

Because of their large surface area and immunological competence, mucosal tissues are attractive administration and target sites for vaccination.

Vaccination via the skin or the mucosae

PURPOSE: The aim of the study was to develop a cheap and fast method to produce hollow microneedles and an applicator for injecting vaccines into the skin at a pre-defined depth and test the applicability of the system for dermal polio vaccination.