Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Microscopic insight on lipid-based nanomedicine in vivo remains limited to the perception of the knowledge that could be obtained: if we interpret only what we see, then we only believe to know. Although believing to know encapsulates an undefined amount of uncertainty in the exploration of lipid-based…

Promotor: Prof.dr. H.A.G. Wijshoff

The main goal of this thesis is to achieve advanced control of binding properties in bis-pyrrolic and macrocyclic pyrrolic receptors by light.

In this project we investigate how the professional development around the theme of inquiry based teaching of teachers from three international schools takes place.

In this research group, led by Dr. Joost Beltman, the aim is to employ mathematical and computational dynamical modelling approaches in order to quantitatively and mechanistically understand the dynamical behaviour and regulation of intracellular networks of genes, proteins and metabolites as well as…

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Om de verkeersveiligheid te kunnen waarborgen en overlast in de binnenstad tegen te gaan, wil de gemeente Enschede als eerste gemeente in Nederland een verbod op fatbikes invoeren. Geerten Boogaard, hoogleraar decentrale overheden, zegt in RTL-nieuws vraagtekens te hebben bij de juridische haalbaarheid…

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

Promotores: Prof.dr.G.R. de Snoo and Dr. R. Heijungs

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Business Process Model and Notation (BPMN) has become the standard for business processes diagrams.

Reijer Passchier, universitair docent Staatrecht in Leiden en hoogleraar Digitalisering en de democratische rechtsstaat aan de Open Universiteit, pleit voor de ontwikkeling van europese techbedrijven, waarbij europa zijn soevereiniteit weet te behouden. Hij waarschuwt vooral niet het ‘destructieve gigantisme-model…

Microneedle-based vaccination has several advantages over vaccination by using conventional hypodermic needles.

The aim of this thesis was to develop aluminium salt-based nanoparticles that may ultimately be used as adjuvant in human vaccines.

Towards a framework that integrates content-based and process-based accounts of mathematical thinking

Promotores: Wim Jiskoot; Ferry Ossendorp

Access to information is a human right (United Nations, 1948). Information technology, such as search engines and recommender systems, has become the key mediator and facilitator to connect people to information (White, 2016). Conversational artificial intelligence (AI) technology is increasingly being…

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

The living plant collections form the heart of the Hortus botanicus Leiden and serve as a vital resource for scientific research. By studying these collections, researchers can explore biodiversity in a unique way and conduct experiments on living material.

Corporate R&D organizations and their relation to academic laboratories.

To what extent can contingent, formative feedback in lectures, facilitated by web-based ICT, increase students’ self-efficacy and (academic, behavioral, and cognitive) engagement? And how are self-efficacy and engagement influencing students’ performance and course evaluations?

The close interaction between organic chemi stry and biology goes back to the late 18th century, when the modern natural sciences began to take shape. After synthetic organic chemistry arose as a discipline, organic chemists almost immediately began to pursue the synthesis of naturally occurring compounds,…

Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua

This thesis describes the design, characterization and application of dextran based crosslinked network.

Duizenden metaalvondsten die door detectorzoeker wijlen Herman Zomerdijk zijn gedaan in de regio Kennemerland schetsen een uniek beeld van Noord-Holland door de eeuwen heen. Hij zocht en verzamelde decennialang historische metalen objecten in Noord-Holland en bouwde zo een unieke metaalcollectie op.

Activity-based protein profiling (ABPP, also termed chemical proteomics), is one of the pillars of chemical biology, and at LED3 we have taken it to the next level. ABPP allows the assessment of protein function in live cells and tissues, which means that the activity of a complete protein family can…

Promotor: E. Bouwman, Co-Promotor: S. Bonnet

The work described in this thesis focuses on the development of linear or cyclized peptide probes against protein N-methyltransferases to characterize their specific binding behavior, providing further binding details for inhibitory activity study.

Over the last decades, aviation safety has improved strongly. As a downside, airline pilots do not have as many opportunities to develop through experience the competencies that they need in critical situations.

A new type of tripodal squaramide-based supramolecular hydrogels is developed and studied.

This thesis explores squaramide-based supramolecular polymers and hydrogels, enhancing their mechanical strength for 3D cell culture.

This research proposal focuses on the investigation of the poetic potentials of negativity through the exploitation of failure in sound based artistic practices - a context that has not been extensively addressed.

Talentvolle Leidse studenten op het podium Practicum Musicae Concerten 2017-2018

In navolging van Duitsland en het Verenigd Koninkrijk, wil de ministerraad een nieuw wetsvoorstel, om verheerlijking van terrorisme en steunbetuiging aan terroristische organisaties strafbaar te stellen. Wim Voermans, hoogleraar Staatsrecht, duidt de zaak in Dagblad Trouw.

On 4 December Professor Emile van Rouveroy van Nieuwaal passed away. Van Rouveroy van Nieuwaal worked at the African Studies Centre from 1967 to 2002, when the ASC was not part of Leiden University yet. He became professor by special appointment at Leiden University on behalf of Leiden Law School in…

Tin electrodeposition applications have rapidly evolved in the past 25 years.

Promotor: Prof.dr. J. Kuiper, Co-Promotor: S.C.A. de Jager

Inspired by natural photosynthesis, perovskite-based photoelectrochemical (PEC) systems are being developed for artificial photosynthesis, aiming to enhance solar-to-hydrogen conversion for green energy.

Promotor: Prof.dr. T. Hankemeier, Co-promotor: T.H. Reijmers

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

Promotor: F.J. van Lunteren, E. Jorin

Uncover novel antimicrobials with prospective health benefits for sea turtles.

Can furan-based resisn be degraded by microbial enzymes in combination with mild pre-treatment?