Image segmentation is a fundamental task in computer vision, with applications ranging from medical diagnostics to archaeological research.

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.

The goal of target discovery is to identify and validate proteins and biological pathways that are involved in the disease process. Modulating these target proteins and pathways with small molecules, therapeutic proteins or other biomolecules (e.g. mRNA) could deliver an effective and safe drug or v…

Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

Promotor: J. A. Bouwstra

The quantum nature of matter and light has grown into a broad and fruitful research field for theorists and experimentalists alike. It combines foundational research with toward applications, the most well known of which is the quantum computer.

In this study, we evaluated the influence of supercritical carbon dioxide (scCO2) spray drying conditions, in the absence of organic solvent, on the ability to produce dry protein/trehalose formulations at 1:10 and 1:4 (w/w) ratios.

Promotor: A. Kros

In the research programme Drug Discovery & Safety, we are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.

Research at the THEOR group is comprised of the following research themes:

Make more fluid: In condensed matter systems, electrons can acquire unusual properties from their interaction with the atomic lattice.

With textnets it is possible to visualize and analyze textual data in novel ways.

Training and learning in the field of Health Care

Special amplifying agents can make MRI scanners and NMR techniques hundreds of times more sensitive. Leiden physicists have now found a method to test their efficiency. More sensitive MRI scans could for example improve our understanding of cystic fibrosis or Parkinson’s disease. Publication in PCCP…

Research at the MCBIM group is comprised of the following research themes:

In the Aarts lab we combine or structure materials, mostly in thin film form, in such a way that the hybrid has different and novel properties or functionalities.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof. dr. A.H. Meijer

Promotor: M.A.G.J. Orrit

Promotor: Prof.dr. M.A.G.J. Orrit

To get an idea of the science communication products and research that is possible, a few examples of student projects of recent years are shown below.

Mapping of bacterial genomes to combat infectious diseases

In 2021 we will start with a weekly lunch time seminar series, online on Mondays from 12 noon onwards.

This thesis develops a method for direction dependent calibration of the ionosphere in radio interferometric data.

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

As part of LUGO’s focus on responsible recycling of e-waste (electronic waste) we participated in the Funky Phone Challenge.

This thesis focuses on the concepts of freedo and fixity as two central topics of my artistic research. I present, analyze. and contextualize four of my works which have explicit links to fleedom and fixify and which demonstrate the dynamic interrelationship between the two.

Dynamic nuclear polarization with paramagnetic agents can enhance nuclear magnetic resonance signals by orders of magnitude. The mechanism of enhancement depends a.o. on the magnetic resonance properties of the agents used. Electron spin relaxation times at NMR relevant magnetic field/microwave frequencies,…

Louk Rademaker is visiting fellow at Leiden University, Lorentz Institute for Theoretical Physics. He studies theoretical quantum matter physics, connecting the material science to fundamental concepts and methods.

This dissertation was to develop effective graphene-based nanofluidic devices by developing scalable fabrication methods and elucidating proton transport mechanisms.

The focus of Jan Zaanen's theoretical physics research was the nature of macroscopic matter that is in one or the other way still in the grip of quantum physics.

Nonadiabatic energy transfer from the translational motion (T) of a molecule impinging on metal surface to the metal’s electrons may determine whether the molecule can lose enough energy to adsorb or react.

This book is the first systematic analysis of the changes in the use of goods and services by households of Black South Africans since the early nineteenth century.

The Leiden Institute of Physics hosted the annual conference of the Dutch Vacuum Society (NEVAC). Experts in the field of vacuum experiments talked about their research. The 2016 NEVAC Prize was awarded to PhD student Martijn Vos from the TU Eindhoven.

Physicists, including Leiden researcher, Sanli Faes, have devised a new technique for studying processes at microscale rapidly and extremely precisely. This new method will make it easier to develop antiviral medication. And it doesn’t stop there. Publication in ACS Nano.

Gold nanoparticles give us a better understanding of enzymes and other molecules. Biswajit Pradhan, PhD candidate at the Leiden Institute of Physics, uses gold nanorods to study individual molecules that would be challenging to detect otherwise. Resulting knowledge can be applied to many research fields,…

Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…

The Academy of Creative and Performing Arts (ACPA) provides artistic research and education in the arts.

A full overview of MacBio PhD Theses.

An overview of the research at the Cancer Dug Target Discovery group.

Commercial enterprises who want to make use of the expertise and facilities are referred to LAB , the commercial unit responsible for specialized laboratory work.

Working for a top faculty? Discover the vacancies at the Faculty of Science and apply immediately.

Research at the Catalysis and Surface Chemistry group is comprised of the following research themes:

LACDR adheres to strict data management rules, with the aim to make our data findable, accessible, interoperable and re-usable. For this reason all LACDR PhD candidates are required to prepare a data management plan and to implement data management rules accordingly. All PhD candidates follow a data…

Numerous beads and pendants of amber, jet and bone have been found in Dutch Neolithic and Bronze Age context, both in settlements and in graves. Because ornaments are personal items, they are closely linked with people’s identity.

What are the biological effects of Chinese herbal medicine in regulation of cancer cell metastasis?

We focus on a better understanding of the mechanisms of cancer drug resistance and metastasis.

From molecule, to cell, to organism. The high-level drug research at the Cell Observatory aimes at reducing the spread of cancer and developing new medicines for tuberculosis.

Bacteria caught red-handed, deeply frozen just as they were about to cause Lyme’s disease. Ariane Briegel is wildly enthusiastic about the wonders she observes thanks to three elements: a freezing technique, a camera-equipped microscope, and AI. ‘It’s fascinating. Every single cell is different.’