474 search results for “drug discovery” in the Staff website
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3 October University: from Russian DNA to drug-related violence
In prehistoric times there was a huge wave of migration, from the steppes in Russia and Ukraine to West Europe. The newcomers’ genes began to dominate. Archaeology research in Leiden into burial mounds in the Veluwe and Utrechtse Heuvelrug areas of the Netherlands yielded this spectacular conclusion.…
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Review paper on the potential impact drug-metabolizing enzymes on brain exposure
PhD candidate Mengxu Zhang (Division of Systems Pharmacology and Pharmacy) published a comprehensive and important review on “The potential impact of CYP and UGT drug-metabolizing enzymes on brain target site drug exposure” in Drug Metabolism Reviews.
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Sebastian Pomplun joins Oncode Institute to accelerate breakthroughs in cancer research
Sebastian Pomplun manages to reach proteins with drugs even where this was thought impossible. That is why he and his research group have been allowed to join Oncode Institute. With nine others, he had been selected from 72 applicants to contribute to Oncode Institute's mission: to accelerate breakthroughs…
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Marieke Liem in The Economist on drug-related murders in Europe
Marieke Liem, professor at ISGA, discusses how the number of drug-related murders has not decreased in the last years
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Leiden archaeologists mentioned in Top 13 Discoveries in Human Evolution during 2023
In a recent article published on PLOS, Drs. Briana Pobiner and Ryan McRae of the Smithsonian Institution National Museum of Natural History discuss the top 13 discoveries in human evolution in 2023.
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Niek Kijk in de Vegte wins the Suzanne Hovinga Award 2023
During the LACDR Fall Symposium, Niek Kijk in de Vegte received the annual Suzanne Hovinga Award for the best master thesis. Niek performed his RP1 research under the supervision of Dr. Natalia Ortiz Zacarias and Prof.dr. Laura Heitman in the Molecular Pharmacology group at the Division of Drug Discovery…
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Carlijn Lems wins the Suzanne Hovinga Award 2020-2021
During the LACDR Fall Symposium the Suzanne Hovinga Award for ‘best master thesis’ was awarded to Carlijn Lems for her master thesis entitled ‘Elucidating the crosstalk between epithelial-to-mesenchymal transition and Programmed Death-Ligand 1: validation and extension of a computational model’. Carlijn…
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LACDR Fall Symposium 2021
On Thursday the 9th of December the LACDR Fall Symposium 2021 took place. Although the plan was to organize this symposium physically, unfortunately this was not possible due to the corona measures and it became an online event.
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Wanda van der Stel - ALTEX Prize Winner 2022
The members of the Board of ALTEX Edition, the ALTEX Editorial Board and ALTEX Editorial Office elect the winner of the annual award out of all main articles published in the previous year; articles including members of the Board of ALTEX Edition or ALTEX Editorial Office as first authors are excluded.…
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Dental remains shed light on drug use in 19th century Dutch village
Archaeologist Bjørn Peare Barthold suspected farmers in a doctorless 19th century Dutch village may have been self-medicating to manage pain and disease. By examining the skeletons' dental calculus this hypothesis could be tested. Science Magazine interviewed him about this new technique.
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Drugs for our immune system in the right place at the right time
Immunologist Leender Trouw specialises in the complement system, which is part of the immune system. In some diseases drugs help activate or inhibit this system. This is best done ‘in the right place at the right time’ − the title of his inaugural lecture.
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Erik Danen new Dean of the Graduate School of Science
The Graduate School of Science starts 2024 with a new Dean. The Faculty Council appointed Erik Danen for the coming four years. He succeeds Eric Eliel, who has held the position since May 2020.
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Discovery of unknown translation of René Descartes’ 'L’homme' in Leiden Bibliotheca Thysiana
From time to time, manuscripts that have remained hidden for centuries turn up in library collections and archives. In the archives of the 17th-century Bibliotheca Thysiana at the Rapenburg in Leiden, kept in the Leiden University Library, Rotterdam researcher Erik-Jan Bos discovered a hitherto unknown…
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Natalia Ortiz – Winner of the 2019 - 2020 KNCV Medicinal Chemistry & Chemical Biology thesis prize
Natalia Ortiz (Division of Drug Discovery and Safety) has been awarded the 2019-2020 PhD-thesis prize by the Division of Medicinal Chemistry & Chemical Biology, from the Royal Netherlands Chemical Society (KNCV-MCCB). The KNCV-MCCB thesis prize is a biannual award which is granted to the best PhD thesis…
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Interview Micha Drukker
Micha Drukker
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Interview
Sabine de Winter
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Discovery Leiden nominated for KIJK: Best Tech-idea of 2021
Using artificial intelligence to find new antibiotics. With that, researchers from Leiden University are nominated by magazine KIJK for the Best Tech-idea of 2021. From September 14 onwards people can vote to crown one of the nominees as the winner.
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Skin researcher calls for multidisciplinary collaboration: ‘I want to pool expertise’
In dermatology, there should be a high level of multidisciplinary collaboration among institutes and specialists, Professor of Translational Dermatology, Robert Rissmann, will say in his inaugural lecture on 8 July. He is building an infrastructure that will put pre-clinical and clinical skin research…
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Joost Batenburg
Science
k.j.batenburg@liacs.leidenuniv.nl | +31 71 527 6985
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Coen van Hasselt
Science
coen.vanhasselt@lacdr.leidenuniv.nl | +31 71 527 3266
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ERC-grant for Sebastian Pomplun to cure disease by controlling gene expression with synthetic transcription factors
Sebastian Pomplun receives an ERC starting grant of 1.85 million Euros in five years. He wants to develop synthetic transcription factors that can enter cells and activate or deactivate specific genes. For example to disrupt cancer-related processes or to trigger the production of an important missing…
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and Italian pharma company receive an EU grant to realise sustainable drug production
With a €1.5 million European grant, industrial ecologist Stefano Cucurachi will work on more sustainable production methods for the pharmaceutical industry. The Italian company Angelini Pharma intends to use the resulting knowledge to make its production process more sustainable.
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for effective application of a new revolutionary cholesterol lowering drug resides in a 30 year old Leiden Patent
‘’ And then the world changed forever ,welcome to the future’’. These are the words that Kausik Ray (President of the European Atherosclerosis Society) spoke when the worldwide first dose of inclisiran, a novel SiRNA based cholesterol lowering agent, was administered at the Cardiology lipid clinic at…
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UMCs join forces to increase pandemic preparedness
Four university medical centres, including the LUMC, are joining forces to increase pandemic preparedness in the Netherlands.
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Una Europa Discoveries
General Assembly
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Pharma-NL application submitted to National Growth Fund
The Ministry of Health, Welfare and Sport (VWS) submitted Pharma-NL to the R&D program of the National Growth Fund, a 20 billion euro program of the Dutch government that intends to create long-term economic growth in The Netherlands.
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Mathematics student Lars Pos wins Robbert Dijkgraaf Essay Prize: 'Discoveries find their application in the most unexpected places'
With his essay 'Why science?', mathematics prodigy Lars Pos (18) won the Robbert Dijkgraaf Essay Prize. Within the theme 'The fascinating workings of science', the bachelor student wrote a plea for the societal value of fundamental scientific research. 'Because you don’t know beforehand where we can…
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Marcel Schaaf
Science
m.j.m.schaaf@biology.leidenuniv.nl | +31 71 527 4975
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Nicolas Rodriguez Idarraga
Faculty of Humanities
n.rodriguez.idarraga@hum.leidenuniv.nl | +31 71 527 2727
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Bas ter Braak
Science
s.j.ter.braak@lacdr.leidenuniv.nl | +31 71 527 2727
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Thomas Hankemeier
Science
hankemeier@lacdr.leidenuniv.nl | +31 71 527 4226
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Marije Niemeijer
Science
m.c.niemeijer@lacdr.leidenuniv.nl | +31 71 527 6105
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Causal Discovery: Challenges and Opportunities
Lecture
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Article eLaw about Fair and equitable AI in biomedical research and healthcare
Eduard Fosch-Villaronga and Bart Custers from eLaw - Center for Law and Digital Technologies wrote an article on Fair Medicine and AI highlighting that AI for biomedical research and healthcare should be beneficent and equitable for everyone.
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Hadassah Drukarch presents at the Fair Medicine and AI conference
At the International Online Conference 'Fair Medicine and Artificial Intelligence' organised by the University of Tübingen (Germany), Hadassah Drukarch, junior researcher at eLaw, gave a presentation on how current algorithmic-based systems may reinforce biases in healthcare. This topic forms part of…
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De dag van Jasper
Jasper Knoester is de decaan van de Faculteit Wiskunde & Natuurwetenschappen. Hoe gaat het met hem, wat doet hij precies en hoe ziet zijn dag eruit? In elke nieuwsbrief geeft Jasper een inkijkje in zijn leven.
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Connect & discover: data registration, deposition and discovery
Network meeting
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Atherosclerosis resembles an autoimmune disease. Marie Depuydt graduated on this topic, with honours
In addition to cholesterol and high blood pressure as risk factors for atherosclerosis, we may need to address our own immune system to prevent a heart attack or stroke. Marie Depuydt revealed which cells exactly reside in the atherosclerotic plaque that narrows an artery. The presence of a diverse…
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Discovery of Reversible Monoacylglycerol Lipase Inhibitors
PhD defence
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Discovery and characterization of new glucosylated metabolites
PhD defence
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Medical Delta AI for Computational Life Sciences
The fact that scientists are increasingly better able to access molecular cell and tissue data also brings with it a new challenge: how can scientists find the information they need for research among the vast amount of data available?
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Is a cancer pill a matter of time?
A cancer pill, preferably without severe side effects, is something we’d all welcome. Is it a matter of time before such a pill is a reality? We put this question to three Leiden researchers and asked how they themselves are contributing to new cancer treatments.
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How to develop cancer drugs with less side effects
Lecture, Tuesday Talks: Science Insights
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Royal honour for emeritus professor Ad IJzerman
Ad IJzerman, Emeritus Professor of Pharmacochemistry, was made a Knight of the Order of the Lion of the Netherlands on 26 April. He was presented with the royal honour by Mayor Elbert Roest in the town hall in Bloemendaal.
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Promising new technique to treat cancer receives NWO grant
Biological chemist Nathaniel Martin and his team received an NWO grant to examine how blocking a specific enzyme in our body, NNMT, could be helpful in the treatment of some cancers. Trials with mice have been promising, and together with the Netherlands Cancer Institute, Martin wants to take the next…
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Harnessing zebrafish xenograft models for ocular melanoma treatment discovery
PhD defence
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Discovery of BUB1 kinase inhibitors for the treatment of cancer
PhD defence
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Antibiotic Discovery: From mechanistic studies to target ID
PhD defence
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mRNA and Drug Delivery with Lipid-based Nanoparticles
PhD defence
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From data to discoveries: machine learning and optimization in space
Lecture