This thesis reports on the influence of induction programs on beginning teachers’ well-being and professional development, and the essential characteristics of an induction program. These topics were explored by means of an interview study and large scale survey study.

What are the genes and molecular mechanisms involved in bacteria-mediated plant drought tolerance?

Atherosclerosis, in particular rupture of atherosclerotic plaques, is the underlying cause of most heart attacks or strokes and is the leading cause of death worldwide.

For effective cancer immunotherapy by vaccination, co-delivery of tumour antigens and adjuvants to dendritic cells and subsequent activation of antigen-specific cytotoxic T cells (CTLs) is crucial. In this study, a synthetic long peptide (SLP) harbouring the model CTL epitope SIINFEKL was encapsulated…

An assessment approach that tailors to children’s instructional needs

Professional learning communities are useful for professionalization but also for the development of induction programmes. In this project, we combine these two worlds into a professional learning communities in which mentors or novice teachers learn about mentoring and at the same time develop an induction…

Transcutaneous vagus nerve stimulation (tVNS) was tested in chronic worriers. tVNS may reduce spontaneously occurring negative thought intrusions. After a worry induction, there was no longer an effect of tVNS. tVNS did not affect physiological responding to worrying.

Atherosclerosis is a chronic inflammatory disease, and vaccination may be an attractive method to induce long lasting protection against endogenous factors that contribute to the development of atherosclerosis. We have shown that for example vaccination against modified LDL or interleukin-12 limits…

Promotoren: G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

The aim of this work was to study the applicability of antigen-coated pH-sensitive microneedle arrays for effective vaccination strategies. Therefore, a model antigen (ovalbumin) was coated onto pH-sensitive (pyridine-modified) microneedle arrays to test pH-triggered antigen release by applying the…

Knowledge and culture subproject 1:

In this Thesis, novel charge induction mechanisms of ionic liquids are treated, tested and experimented on complex oxides, in particular cuprates.

Oxidation is a common degradation pathway that affects therapeutic proteins and peptides during production, purification, formulation, transportation, storage and handling of solid and liquid preparations. In the present work we review the scientific literature about structural and biological consequences…

We showed that constitutive and inducible chemical and morphological defenses against Western flower thrips differ between tomato and chrysanthemum plants.

Can dynamic testing provide us with insight in children’s potential for learning?

Promotores: J.J.M.M. Rutten, F.S. de Boer, Co-promotor: M.M. Bonsangue

Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa

Promotores: Prof. dr. G.R. (Geert) de Snoo, Dr. E. (Ester) van der Voet

'Collaboration, Mediation, and Comparison: Epistemological Tools from Theory-driven Fieldwork Practice' is written by Cristina Grasseni and published in Anthrovision.

In contemporary India, the regional state of West Bengal has often been perceived as somewhat of an aberration in the wider context of a rather chaotic democracy, as the Left Front (spearheaded by the Communist Party of India-Marxist, CPIM) demonstrated a rare instance of political stability, decisively…

Key publications of the Biologics Formulation group

The first results of the “Policing European Metropolises project” (PEMP) that associate Professor Elke Devroe and Professor P. Ponsaers launched in April 2013 are now published. Having been the referent for The Netherlands and Belgium in the Urbis project (Leonardo programme), the project focuses on…

Control of infectious diseases poses continuous challenges for human health.

Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn, Co-promotor: Dr. M.J.M. Schaaf

This article describes the creation of an app that can help raise climate awareness and the action globally.

The authors delve into the varying degrees to which institutions across different nations connect foreign events to their respective country's domestic affairs.

Peter Flach is Professor of Artificial Intelligence at the University of Bristol. An internationally leading scholar in the evaluation and improvement of machine learning models using ROC analysis and calibration, he has also published on mining highly structured data, on knowledge-driven and explainable…

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar-Jagalska

How can historically-informed performers step outside the confines of the work-concept?

It is an established fact that the Standard Model has to be extended to explain the so-called Beyond the Standard Model (BSM) phenomena: dark matter, matter-antimatter asymmetry of the Universe and neutrino flavour oscillations.

In comparing a selection of 18th-century histories to a representative sample of 19th-century histories of science, this project inquires: Which early modern vices persisted into the 19th century and to what extent were those vices embodied in anecdotes, conveyed through commonplaces, or symbolically…

Influenza CD8(+) T-cell epitopes are conserved amongst influenza strains and can be recognized by influenza-specific cytotoxic T-cells (CTLs), which can rapidly clear infected cells. An influenza peptide vaccine that elicits these CTLs would therefore be an alternative to current influenza vaccines,…

Drawing on a broad array of sources, this project examines modern retrievals of Bacon’s idols, thereby testing Justus von Liebig’s intriguing observation, back in 1863, that Bacon’s name lived on mainly in mottos or stereotypical phrases. More importantly, it examines the rhetorical purposes served…

What role play stress and fear in forming of nocebo hyperalgesia?

The soil ecosystem consists of the largest reservoir of biodiversity on Earth.

This project is aimed at 1) elucidating the role of attention in itch and pain, including orientation, and attentional disengagement (i.e., directing attention away) from itch and pain; and 2) modifiability of these attentional processes.

This project aims to identify which aspects of exploring a novel environment produce beneficial effects on memory. The effects of novelty will be investigated across the lifespan, including children, adolescents and older adults.

What is the effect of a dynamic training in children’s inductive reasoning skills and how is it related to children’s school performances and language development.

Uncovering task solving processes in dynamic testing

An integrated approach for the simultaneous prediction of polypharmacology and binding affinity/potency of small molecules.

The Leiden Index of Depression Sensitivity (LEIDS) measures cognitive reactivity (CR) to sadness, an aspect of cognitive vulnerability to depression, conceptually similar to rumination.

How do Chinese language teachers negotiate who they are as teachers when they work abroad? This dissertation offers clear, practice-oriented answers. It examines teacher identity - the everyday answer to 'What kind of teacher am I here?' - as it is reshaped through classroom interactions, institutional…

How does stress affect different components of behavioral impulsivity and aggression in patients with Borderline Personality Disorder compared to clinical controls (patients with Attention Deficit Hyperactivity Disorder) and healthy controls?

The Immune Activation and Tolerance group is headed by Dr. Bram Slütter. Vaccination is an experimental, but promising, treatment strategy for atherosclerosis. Previous work has shown that immunization of mice with modified LDL particles can reduce atherosclerotic lesion development, however such vaccines…

The Collective Experience of Empathic Data Systems (CEEDs) consortium developed novel integrated technologies that support experiencing, analysing and understanding of very large datasets.

The effects of many treatments are determined, to a significant degree, by factors other than the medicine or treatment itself. For example, placebo effects can be equal to the effect size of for example antidepressants or painkillers. Contributing factors are the trust placed in the doctor, the expectation…

What is the role of stress and stress-related hormones in emotion regulation?