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How do pathogenic mycobacteria alter lipid metabolism in human cells and patients, and which disrupted pathways could be targeted for new antibiotics?

The knowledge and skills you will acquire will qualify you for many different jobs. Possible careers include: researcher of learning, behavioural and emotional problems in children, or designer of prevention and intervention programmes.

Get to know us through our online and in-person events for prospective students!

A new therapy for the serious Graft-versus-Host disease

This Research Master’s programme will train you to become a researcher.

Starting next academic year, part of the master's in Population Health Management will be available at the University of Birmingham in England. What is the advantage of studying at both universities? Master's student Ferdiko Hutamadella studied in Birmingham as well as Leiden before the partnership…

A master in Psychology at Leiden University combines theoretical knowledge with academic and professional skills, making you an attractive candidate for many employers.

Light makes us flourish – in this respect we humans are just like a rose or an azalea. Light can also be used to treat people who are ill. In Leiden, Sylvestre Bonnet and Esther Habers are working – each in their own discipline – on new applications of light in a clinical context.

Overview of all dissertations published by PhD candidates from CML.

He is occupied with the home stretch of his promotion. But in between, there is another challenge: Michael Meijer is going through to the finals of ‘The Smartest Chemist of the Netherlands’. On Tuesday 9 October, he and five others fight for this title during the Evening of Chemistry. ‘I was dragged…

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This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Effects of maternal smoking, premature birth, intra-uterine growth retardation and asphyxia on child development.

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Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

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Promotor: Prof.dr. J. Kuiper

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm

Why do many medical institutions struggle to use AI in their clinical practice? What are the essential steps for and before an effective implementation of AI in radiology workflow? How can AI implementation trigger enduring improvements in the clinical process? The book shows how change management is…

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

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Prostate cancer (PCa) is one of the most prevalent cancer in males.

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An important feature of atopic eczema (AE) is a decreased skin barrier function. The stratum corneum (SC) lipids - comprised of ceramides (CERs), free fatty acids (FFAs) and cholesterol - fulfill a predominant role in the skin barrier function.

The potential of liposomal cancer vaccines

The indane (2,3-dihydro-1H-indene) ring system is an attractive scaffold for biologically active compounds due to the combination of aromatic and aliphatic properties fused together in one rigid system.

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

After graduation you have a lot of opportunities: academics are highly sought after in Dutch secondary education or mbo teaching. You can also aim for a management position or work as a researcher within the field of Life Sciences.

In the Master’s programme Research in Bio-Pharmaceutical Sciences of Leiden University you are trained for a scientific career in drug research and development.

Growth and development affect the metabolism of drugs administered to neonates, infants, and children.

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

This thesis focuses on enhancing predictions of central nervous system drug exposure using the LeiCNS-PK3.0, a physiologically based pharmacokinetic model.

If you wish to know exactly what is going on in a healthy or sick human body, and at various levels such as molecule, cell, tissue, organ, larger systems and a person as a whole? Do you wish to learn how to do research which contributes to diagnoses, treatment and prevention of diseases? Then the bachelor…

To increase clinical success rate of drugs, a better understanding of drug action mechanism and disease dynamics is required. Metabolomics, which studies small molecules involved in biochemical processes in organisms, has shown to be a useful tool for this better understanding.

Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)

Are there any differences in gaze behavior between high and low socially anxious individuals? What factors influence the relation between social anxiety and gaze behavior?

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

Promotor: Prof.dr. J. den Hertog

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

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Key publications of the Biologics Formulation group

In the research programme Microbial Sciences we perform state-of-the-art research in the field of biotechnology and microbial sciences.

Assessing and implementing new diagnostics strategies for stratifying patients

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

Understanding individual differences in self-regulation in boys with ODD/CD on the level of brain, cognition and behavior