This thesis investigates how cell shape and collective behavior influence the dynamics and structure of biological tissues, which are crucial for understanding processes like embryonic development, tissue regeneration, and metastasis.

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.

Electrons in a crystal lattice have properties that may differ from those of a free electron in vacuum.

The key characteristic of active matter is the motion of an emergent collection (such as a flock of birds), which is driven by the consumption of energy by its active components (i.e. individual birds).

This thesis describes the development and validation of new high-contrast imaging techniques, with the ultimate goal of enabling the next generation of instruments for ELT-class telescopes to directly image Earth-like extra-solar planets orbiting around nearby stars.

Cathodic corrosion is a relatively unknown phenomenon that can severely etch metallic electrodes at cathodic (negative) potentials.

Pseudomonas Aeruginosa is a Gram-negative bacterium which can form biofilms, increasing its resistance against antibiotics and the host immune system. Polysaccharides are an integral part of this biofilm, one of these polysaccharides is called Psl. PslG is a glycosidase, able to cleave this polysaccharide,…

This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.

The symposium is open to all registered participants and consists of a one-day programme and a poster session.

The elementary excitations of magnets are called spin waves, and their corresponding quasi-particles are known as magnons. The rapidly growing field of Magnonics aims at using them as information carriers in a new generation of electronic devices, (almost) free of electric currents.

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

PhD defence

Lecture

Programme

The stratum corneum (SC) plays a fundamental role in the barrier function of the skin. The SC consists of corneocytes embedded in a lipid matrix.

Promotor: Prof.dr. G.J. Kroes

The Leiden University Centre for International Relations (LUCIR) is a multi-disciplinary platform promoting research and education on international relations at Leiden University.

Promotor: Prof.dr. M.A.G.J. Orrit

This study aims to make a practical contribution to a new understanding and use of 3D reconstructions, namely as ‘laboratories’ to test hypotheses and visualize, evaluate and discuss alternative interpretations.

Long-distance Trade in Early Medieval Landscapes (ca. 6th-12th centuries)

Salt crystals, a nano-sized golf stick and molten glass. The LION Image Award competition of 2023 yielded a lot of beautiful images once again. But in the end, only one can be the winner.

From molecule, to cell, to organism. The high-level drug research at the Cell Observatory aimes at reducing the spread of cancer and developing new medicines for tuberculosis.

Since the early 1990s, one can isolate the optical signal of a single molecule and single-molecule spectroscopy has quickly grown into an important research field.

Now and then we organise book launches to present the latest publications, both academic and popular, in our broad field.

Discover the impact of Instagram on our daily lives in the book On Display. Boy and Uitermark delve into the platform's influence on our social interactions.

In this thesis, single-cell approaches were applied to characterize the impact of aging on the immunological B cell landscape in different models of atherosclerotic cardiovascular disease, with the goal to identify and study new B cell-associated biomarkers and therapeutic targets to halt atherosclerosis…

Macromolecular Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University, comprising the PIs Marcellus Ubbink, Remus Dame, Lars Jeuken, Anne Wentink, Sebastian Geibel, Anjali Pandit, René Olsthoorn, Alia, and Steffen Brünle.

The Leiden Institute of Chemistry (LIC) is the basis for research and collaborations of the Leiden chemistry groups. Chemistry is the central science enabling a healthy future in a sustainable society. Chemistry researchers at Leiden University take a fundamental approach in finding tailored solutions…

A 35-year-old uranium crystal will not disclose its secret: what causes a dramatic phase transition at 17.5 Kelvin? Thanks to a new artificial intelligence approach, half of the possible explanations are excluded, but the definitive answer remains to be found. 'It is very frustrating', says physicist…

The Data-Driven Drug Discovery Network (D4N) is an initiative by researchers from Leiden University and collaborators to join efforts in applying and developing novel techniques from data science to drug discovery and related topics from bioinformatics.

Research in this group, headed by Gerard van Westen, focusses on computational methods integrated in different parts of the drug discovery process. More specifically, topics include innovative treatments for cancer, selectivity modeling, translational research, allosteric modulation, drug resistance…

The discovery of new medicines is a tedious and lengthy process. On average, over 10,000 molecules need to be studied for one to become a drug and reach the patient. Part of that process are the very costly clinical trials in humans, and candidate drugs often fail due to side effects or lack of efficacy.…

Target selectivity is an important aspect of any drug molecule, and certainly a parameter to be optimized. That is not trivial for a number of reasons. First of all hundreds of drug targets (receptors, enzymes, ion channels) exist, and no single lab in the world has assays for all of them.

Jacques Sevat discussed the practical and legal aspects of global collateral management: collateral management to reduce the credit risks a global bank such as ING Bank runs every day.

Research and education at the Leiden Institute of Chemistry is overseen by the Institute Board. The Board and representatives of the two research themes form the Management Team. The Scientific Council (WERA), the Institute Council (I-Raad) and the platform for PhDs and post-doctoral co-workers (LIC73)…

Three quantum-safe cryptography methods have been standardised for worldwide use since this week. Léo Ducas co-designed the two primary PQC methods selected for this standardisation. Ducas is part of the Cryptology group at Centrum Wiskunde & Informatica (CWI) and is also professor of Mathematical cryptology…

Nematic liquid crystals form the key ingredients of most tv screens. The active version of these complex fluids forms a useful model for physicists to research the responses of active matter—like bacteria or traffic flows—to mechanical and geometrical cues. An international research team publishes their…

Leiden chemists Marc Koper and Ian McCrum have discovered that the degree to which a metal binds to the oxygen atom of water is decisive for how well the chemical conversion of water to molecular hydrogen takes place. This insight helps to develop better catalysts for the production of sustainable hydrogen,…

High-temperature superconductivity is one of the big mysteries in physics. Milan Allan’s research group used a Josephson Scanning Tunneling Microscope to image spatial variations of superconducting particles for the first time, and published about it in the journal Nature.

We don’t understand how some materials become superconducting at relatively high temperatures. Leiden physicists have now found a surprising connection with auxiliary black holes. It enables us to use our knowledge of black holes on the mystery of high-temperature superconductivity. Publication in Nature…

Quasicrystals are crystals with ‘impossible’ five-fold symmetries, which nevertheless were synthesized in the lab in 1982. Paul J. Steinhardt helped figure out their structure, but he didn’t stop at that.

When you think of physics, do you think only of complicated formulas? You’re not the only one. Therefore, every year, the Leiden Insitute of Physics organises the LION Image Award to show another side of physics: beautiful images about intriguing science. The winner of the 2022 photo competition captured…

An indian stepwell on a nanoscale. That is what postdoc Nakkiran Arulmozhi calls the pattern he saw when he corroded a special kind of platinum crystal. The unique images show the destructiveness of the process, but also show how predictable it is.

An important discovery makes it possible to communicate complex information among multiple people without the message being cracked. The communication can also relate to complex information.

Het project heeft plaats gevonden in de QMO groep onder begeleiding van Dr. Michiel de Dood en Dr.ir. Sense Jan van der Molen. De titel van de presentatie is:

The Leiden Institute of Chemistry (LIC) offers a unique tailor-made programme in Chemistry. You can customize the programme to your own interests and ambitions with the help of your own personal mentor. Your study will focus on either Chemical Biology or Energy & Sustainability. During the Master's…