In the research programme Drug Discovery & Safety, we are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.

How effective is eye movement desensitization and reprocessing therapy in targeting epilepsy-related anxiety?

How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?

This Master enables you to practice professional activities such as: lead research projects and develop technically qualified projects in the field of transfusion medicine.

A major challenge in the formulation of biopharmaceuticals is to overcome their inherent instability during production, storage, transportation, handling and administration. We are studying underlying mechanisms of degradation of biopharmaceuticals (including therapeutic proteins, vaccines and advanced…

Valedictory lecture

A cancer pill, preferably without severe side effects, is something we’d all welcome. Is it a matter of time before such a pill is a reality? We put this question to three Leiden researchers and asked how they themselves are contributing to new cancer treatments.

A therapeutic vaccine against HPV-16 (type 16 human papillomavirus) improves the survival rate in cervical cancer patients. A new study by ISA Pharmaceuticals B.V. (a Leiden-based biotechnology company) and the Leiden University Medical Center (LUMC) shows that this vaccine produces a more robust response…

In order to optimize treatment, it is necessary to closely monitor and manage the patient’s health status by means of ‘precision diagnostics, personalized prognosis and targeted therapy’. The specialisation combines the techniques and applications of these sensing (monitoring) and stimulation techniques.…

Metastasis is responsible for over 90% of cancer-related deaths and arises from the ability of a small subset of tumor cells to detach from the primary tumor, overcome multiple biochemical and mechanical barriers, disseminate through the body, and colonize distant organs.

An overview of Quantitative Pharmacology projects

Tuberculosis (TB) is associated with 1.5 million deaths annually. There is a need exists to optimize both current as well as novel antibiotic combination treatment strategies to improve the effectiveness and safety of treatments against TB.

The GMP Facility facilitates development and production of Advanced Therapy Medicinal Products (ATMPs) and chemical (peptide) synthesis.

As a psychologist and pilot, Bert Busscher is interested in the phenomenon often termed as fear of flying. Busscher discovered that the heart rate of a person undergoing a therapeutic flight shows how much they still suffer from fear of flying. The post-flight heart rate can even predict whether the…

Imagine how much time, money and discomfort it would save: a personalised treatment for each individual patient. Precision medicine like this is coming ever closer, thanks in part to Elise Dusseldorp’s algorithms. They retrieve a wealth of information from research data.

Our team is involved in the translation and adaptation of several questionnaires, for research purposes. Information about each questionnaire is listed below.

A master's degree in Psychology at Leiden University combines theoretical knowledge with academic and professional skills, making you an attractive candidate for many employers.

Op zaterdag 27 februari organiseert Stichting Zenobia het Vijftiende Zenobiacongres, met de titel Van de Levant tot de Lagune: Venetië en het Oosten. Het congres zal online plaatsvinden en is vrij toegankelijk.

The LUMC has a longstanding tradition researching the role of the immune system in infectious diseases, transplantation and auto-immune diseases.

For more information regarding ongoing research projects, please contact Prof. Johan Kuiper.

This thesis examines silicon pore optics (SPO), a technology that exploits silicon wafers from the semiconductor industry to create extremely high quality X-ray optics, by studying its manufacturing process, applications, and prospects.

Registration for the Co-Align 2023 conference is open!

In this PhD thesis, available data on the PK and/or PD of different targeted therapies, chemotherapy and immunotherapies obtained during both routine clinical practice and prospective clinical studies were analyzed.

Elk jaar organiseert het LIBC in samenwerking met de gemeente Leiden een Publieksdag over hersenonderzoek.

Nanoparticles exhibit a number of adjustable properties, e.g., their size, shape, and surface and core chemistry, which can be further diversified with different functional moieties. This opens a broad field for application in diagnostic and therapy. In this respect, the use of a polymeric hybrid material,…

Are you looking for a research project?

The research within the Division of Cell Systems and Drug Safety, headed by Prof. Bob van de Water, is focused on novel therapeutic modalities and novel concepts in early drug discovery, in order to develop more effective and safer therapeutic strategies. We generate advanced cell and computational…

Can drugs that target host signaling pathways be used to eradicate antibiotic-resistant bacteria?

Het project heeft plaats gevonden onder begeleiding van Prof.dr.ir.Tjerk Oosterkamp. De titel van de presentatie is:

Op vrijdag 4 april 2025 organiseert de werkgroep Stedengeschiedenis een bijeenkomst bij de Rijksdienst voor het Cultureel Erfgoed onder de titel ‘Archeologie en de stad’. De studiedag is gratis en voor iedereen toegankelijk.

Het project heeft plaats gevonden in de Gorter LUMC groep onder begeleiding van Dr. J.W.M. Beenakker en prof.dr.ir. T.H. Oosterkamp . De titel van de presentatie is:

Het project heeft plaats gevonden in de KM3NeT Nikhef Amsterdam groep onder begeleiding van Dr. D.F.E. Samtleben en Prof.dr.ir. T.H. Oosterkamp. De titel van de presentatie is:

Het project heeft plaats gevonden in de QMO groep onder begeleiding van Dr. Michiel de Dood en Dr.ir. Sense Jan van der Molen. De titel van de presentatie is:

Promotores: Prof. Dr. Th.J.C. van Berkel, Prof. Dr. M. van Eck

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The aim of this thesis was to study phage infection in Streptomyces, focused on cell wall-deficient cells. Bacteriophages (or phages in short) attach to the cell wall of bacteria after which they replicate and lyse the host cell.

Projects within the theme ‘Computational Biology’ aim to employ mathematical or computational dynamical modelling approaches to discover novel concepts that are important for drug development.

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

Promotor: M.A.G.J. Orrit

Speech Prosody is the biennial meeting of the Speech Prosody Special Interest Group (SProSIG) of the International Speech Communication Association (ISCA).

SBB research focuses on the complex operational, organisational dynamics of technology-intensive sectors.

The research of the Biotherapeutic Delivery group led by Joachim Van Guyse focuses on developing novel polymer-based formulations for therapeutic nucleic acid and protein delivery. The research revolves around developing structure-activity relationships between the chemical structure of polymers, the…

MHC class I and MHC class II molecules present peptides to the immune system to drive proper T cell responses. Pharmacological modulation of T-cell responses can offer treatment options for a range of immune-related diseases.

This thesis explores squaramide-based supramolecular polymers and hydrogels, enhancing their mechanical strength for 3D cell culture.

Explore how skateboarding functions as a prefigurative learning tool in 'Skate/worlds.' This volume examines skateboarding's therapeutic potential, its role in queering and decolonizing education, and its impact on parenting and care work through perspectives from writers, educators, and activists.

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