This thesis seeks to investigate how cancer-associated mutations affect the pharmacological properties of selected GPCRs—primarily A2AAR and 5-HT2CR—through a combination of ligand binding assays, signaling readouts, kinetic profiling, and cellular functional assays.

A new technique using fluorescent imaging to track the actions of enzymes might aid drug design for new anti-cancer, inflammation and kidney disease treatments. Researchers at the University of York and Leiden University have published these findings in Nature Chemical Biology.

Dr. Ben Van Rompuy participated as an invited expert in the annual Congress of the International League of Competition Law (LIDC), held this year in Vienna from 9 to 12 October.

We would like to draw your attention to the following advertisement which was originally disseminated by the Dutch Breast Cancer Foundation, in collaboration with Leiden University

Developing a better treatment for patients with head and neck cancer, that is what Binanox, The 2022 iGEM Leiden team, want to achieve. They hope to raise at least 10,000 euros for this cause. Support their crowdfunding campaign today.

Patients with incurable breast cancer remember more information about their treatment if their doctor is more empathetic during consultations. These are the results of research by psychologists from Leiden University in collaboration with Nivel research institute. Publication in Patient Education and…

This thesis investigates how cell shape and collective behavior influence the dynamics and structure of biological tissues, which are crucial for understanding processes like embryonic development, tissue regeneration, and metastasis.

On 16 April, an edition of Zembla, the Dutch documentary programme produced by BNNVARA, investigated the connection between Thierry Baudet, leader of Dutch political party Forum for Democracy and the Kremlin. Ben de Jong, visiting lecturer at the Institute of Security and Global Affairs, was interviewed…

Ben de Jong, a guest lecturer at the Institute of Security and Global Affairs, appeared as a guest on NPO Radio 1 to discuss number stations that are used to send secret messages to spies in enemy territories.

Ben de Jong, inlichtingen-deskundige en gastonderzoeker en -docent bij het ISGA aan de Universiteit Leiden, werd geciteerd in een artikel in het Algemeen Dagblad over topografische kaarten die de Russen tijdens de Koude Oorlog gebruikten. De Sovjet-Unie beschikte over een ongelofelijke hoeveelheid…

Arco Timmermans is Professor by special appointment Public Affairs at the Institute of Public Administration. On Dutch television programme 'EenVandaag', he discussed the remarkable changes that have been made in a report on lung cancer in and around the Dutch city of Beverwijk that was presented by…

Pharmaceutical research should make more use of data science, says Gerard van Westen, postdoctoral fellow at the Leiden Academic Centre for Drug Research (LACDR). ‘If we want to have better drugs, we should start with data.’

How can we translate more fundamental discoveries into clinical solutions for patients? From that question, the Oncode Accelerator programme emerged. Professor of Molecular Physiology Mario van der Stelt has been one of the driving forces behind it since its inception. In an interview on the website…

Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea

Shortly before Remembrance Day, a new film was launched about the life and legacy of Ben Telders. Telders was professor of Dutch Law at Leiden University at the start of the Second World War; he was imprisoned in a concentration camp on account of of his protest against the Nazis.

This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.

Could we stop cancer cells by cutting off their energy supply? That’s what Dione Blok, a bachelor’s student in Bio-Pharmaceutical Sciences, aimed to find out during her thesis research. She investigated a compound that affects the tumour cells’ energy metabolism. ‘Hopefully, these insights will provide…

Promotor: Prof.dr. B. van de Water, Co-promotores: J.W. van der Laan, C.L.E. Siezen

How do cells repair their damaged DNA—and what happens when that process is hindered and cancer arises? Sarah Moser has taken a closer look during her PhD, uncovering surprising insights that could help improve future cancer treatments.

The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…

As part of the HTSM2017 funding program, the LACDR division for Systems Biomedicine and Pharmacology received 1.08 million euros for a research project to develop novel engineering approaches to fight cancer.

On 23 April 2021, Professor Alfred Vertegaal from the Department of Cell and Chemical Biology at the Leiden University Medical Center (LUMC) delivered his inaugural lecture ‘Unraveling and exploiting cellular communication codes’. Vertegaal used the opportunity to describe how research in the field…

Research at the Leiden University Medical Center (LUMC) Department of Pathology shows the power of artificial intelligence (AI) applied to endometrial carcinoma microscopy images. The group of Dr. Tjalling Bosse offers novel insights that could improve diagnosis and treatment of uterine cancer. Their…

One used 3D cell models to study colorectal cancer, while the other used machine learning for more efficient blood donation. For these achievements, Marieke Vinkenoog and Simon Christian Hansmann were awarded the Krijn Rietveld Memorial Innovation Award on Tuesday 2 September.

The more data from cancer research we pool, the better we can search for new treatments. But how can we keep patient data safe when sharing it? Leiden researchers will tackle this challenge in a major European project.

Marta Fiocco, professor in the Mathematical Institute, has received a grant for analysing data on chemotherapy in children suffering from leukaemia. The work involves developing and applying new statistical methods that will help determining the optimal dose of chemotherapy.

The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.

A new app is able to calculate personalised survival probabilities for patients suffering from soft tissue sarcoma. Doctors and patients can use the app to calculate personalised survival probabilities together. Mathematician Anja Rüten-Budde received her doctorate for her research into survival probability…

This study is important because it seeks to uncover whether clinicians' communication influences neurobiological and physiological outcomes for patients.

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

When you think of physics, do you think only of complicated formulas? You’re not the only one. Therefore, every year, the Leiden Insitute of Physics organises the LION Image Award to show another side of physics: beautiful images about intriguing science. The winner of the 2022 photo competition captured…

Luca Giomi has the first results of his ERC consolidator grant. He discovered that epithelial cells move collectively but in different ways, depending on the scale you look at. It is hexatic at small scales, and becomes nematic at larger scales: it is a multiscale order. This collective movement of…

Half of all people with cancer in the Netherlands are aged 70 or older, and as the population continues to age, this number will only rise. Yet vulnerable older people with cancer are often overlooked, says PhD candidate Joosje Baltussen.

Ben de Jong and Paul Abels, both working for ISGA, discuss the Russian claim that espionage equipment was found in Dutch newspaper Algemeen Dagblad (AD). According to the Russians the equipment was found in one of the cars used by their diplomats in The Hague.

Promotores: Prof.dr. M.K. Richardson, Prof.dr. H.P. Spaink

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Thirty years ago, mutations in the BRCA1 gene were first linked to hereditary breast and ovarian cancer, establishing a genetic basis for cancer development.

During illness, the stiffness or viscosity of cells can change. Tom Evers demonstrated this by measuring such properties of human immune cells for the first time. ‘The stiffness of certain cells could be a way to make a diagnosis,’ Evers said. He defended his thesis on March 26th.

On 14 April, the National Growth Fund awarded million euros in grants to two consortia in which Leiden's science faculty is involved. Pharma-NL will receive 80 million euros and Oncode-PACT 325 million euros. Pharma-NL wants to make medicines available to the patient faster and more sustainably. Oncode-PACT…

We study how communication can heal and harm when patients are confronted with an illness. Most of our studies focus on serious illnesses such as advanced cancer. Communication lies at the heart of medicine, yet we do not always know which specific communication helps patients. Moreover, many complaints…

Alumnus Ben Smulders has worked for the European Commission for the past 33 years. ‘The discipline and depth that I experienced during my student days has helped me through various stages of my professional career.’

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

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In this thesis, the researcher developed a nanosystem based on the metallophilic Interaction between cyclometalated complexes.

How can you ensure that more experimental drugs reach the finish line? At the moment, only one in twenty cancer drugs that are tested on humans makes it to the market. This is an enormous loss for patients and society. With a grant from the National Growth Fund, Oncode-PACT aims to efficiently select…

Accelerating the development of new cancer medicines by joining forces—that’s the mission of Oncode Accelerator, a Dutch consortium that recently welcomed three Leiden-based PhD candidates. Under the guidance of Gerard van Westen, Marc Boef, Remco van den Broek, and Lucina-May Nollen are exploring how…