In this Ph.D. thesis we study the interaction of low energy electrons with thin materials, namely layered materials (graphene, hexagonal boron nitride, molybdenum disulfide) and organic films. At these low energies the quantum mechanical wavelength of the electron wave function is in the order of a…

Beyond Empires explores the complexity of empire building from the point of view of self-organized networks, rather than from the point of view of the central state.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Sander van Kasteren (Professor of Molecular Immunology) makes the invisible visible. He will explain more in his inaugural lecture.

For the first time, astronomers have detected the presence of complex organic molecules, the building blocks of life, in a protoplanetary disc surrounding a young star. The discovery reaffirms that the conditions that spawned the Earth and Sun are not unique in the Universe. The results are published…

How do Humanitarian Response Organizations (HROs) and Virtual & Technical Communities (V&TCs) collaboratively govern disaster sensemaking processes, and what challenges shape the effectiveness of these collaborations between 2010 and 2016?

This study discusses the position of the monasteries in pre-1950s Tibetan societies and how that position was informed by Buddhist monastic ideology.

Promotor: J. A. Bouwstra

In this study, we evaluated the influence of supercritical carbon dioxide (scCO2) spray drying conditions, in the absence of organic solvent, on the ability to produce dry protein/trehalose formulations at 1:10 and 1:4 (w/w) ratios.

An international team of laboratory astrophysicists and astrochemical modellers has shown that glycine, the simplest amino acid and an important building block of life, can form under the harsh conditions that govern chemistry in space. The results have been published this week in Nature Astronomy and…

Microbial rhodopsins are photosensitive pigments implemented in the growth and adaptation of a large population of microorganisms.

Understanding how nature captures and transfers solar energy is essential both for elucidating biological photosynthesis and for guiding the design of artificial light-harvesting systems.

Research and education at the Leiden Institute of Chemistry is overseen by the Institute Board. The Board and representatives of the two research themes form the Management Team. The Scientific Council (WERA), the Institute Council (I-Raad) and the platform for PhDs and post-doctoral co-workers (LIC73)…

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.

Last year, chemists Dennis Wander and Hermen Overkleeft contributed to an important discovery about a widely used cancer drug. Their research has now been recognised as Finalist for the PNAS Cozzarelli Prize in the Biomedical Sciences class.

Research at the BPOC/SSNMR group is comprised of the following research themes:

The Plant BioDynamics Lab (PBDL) is a laboratory dedicated to experiments designed to develop and validate quantitative mathematical models of dynamical processes in biology. The principal objective of developing these models is to make quantitative predictions about these processes.

Metabolomics group, LCQUI, Universidade UENF, Campos dos Goytacazes/Rio de Janeiro - Brazil

This thesis discusses several questions regarding the double ramification cycle as a Chow class on the moduli space of stable n-pointed genus g curves using tools from so-called logarithmic geometry.

Since February 1st, 2017 Célia Fonseca Guerra is appointed as professor at the LIC with a chair in applied theoretical chemistry. She will be a member of the Theoretical Chemistry group. Her research interests are related to bioinorganic chemistry and catalysis and her appointment at the LIC will strengthen…

The aim of this thesis is to study cell-cell interactions and the development of an assay to explore and quantify the exchange of membrane compounds.

Supramolecular polymers are class of materials that are formed by non-covalent interactions such as hydrogen bonding, π-π interactions, electrostatic interactions and the hydrophobic effect.

Promotor: Prof.dr. E. Bouwman

Promotor: E. Bouwman, Co-Promotor: S. Bonnet

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

This thesis studies theoretical surface chemistry within the field of heterogeneous catalysis.

During the 20th anniversary meeting of the Netherlands' Catalysis and Chemistry Conference, Marc Koper received the Netherlands Catalysis and Chemistry Award. ‘The ultimate candidate for the prize’, it says in one of the recommendation letters.

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

Andreas Bender, Assistant Professor for Medicinal Chemistry in the Medicinal Chemistry Division of the Leiden / Amsterdam Center for Drug Research, received the

Leiden chemist Roxanne Kieltyka is part of the 2018 Talented 12 list of the American Chemical Society. That was announced by the journal Chemical & Engineering News on 19 August.

The Chemistry and LST master’s programmes are both structured on an individual basis and well-embedded in the research at the faculty. Those are the main conclusions of the oral report at the end of the visit of the visitation panel on October 10th.

How do fats and enzymes in the brain contribute to multiple sclerosis? In his PhD research, Daan van der Vliet combined chemistry and neuroscience to gain new insights into how brain disorders develop.

This article explores how employees use leadership behaviours and how characteristics of the organizational context affect their engagement in leadership.

This article aims to explore the determinants of inclusive leadership. This type of leadership is valued for social equity and fairness.

LED3 is the combined effort of four excellent institutes of Leiden University. Through joined hands, we are able to give rise to a more effective early drug discovery pipeline. Let us briefly introduce the institutes.

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

Not experiments and lab coats, but computers and artificial intelligence: this year's Nobel Prize in Chemistry went to the inventors of the groundbreaking AI model, AlphaFold. This programme accurately predicts protein structures based on their genetic code—a crucial step in understanding biological…

Some examples of AI-research done at Leiden.

It has been a long-standing mystery how complex biological structures emerge from such seemingly uncoordinated building blocks as cells and tissues, in the presence of only minimal environmental guidance.

The redox-conversion reaction of metal-disulfide and metal-thiolate complexes are important, as they may shed light on electron-transfer reactions that often occur in Nature.

Leiden University will be conferring three honorary doctorates in its special anniversary year. They will be awarded to Eliot Higgins, truth finder and founder of Bellingcat, Bonnie Honig, expert in feminist theory and legal theory, and Kelly Chibale, professor of organic chemistry, who works on prevention…

How do classroom demonstration experiments help students learn chemical reasoning? Marie-Jetta den Otter, PhD student at ICLON, researched this. She defends her thesis on 6 December.

Tackling key challenges of Chemical Biology and Medicinal Chemistry to aid drug discovery is one of the focus areas of Leiden University. To this end, the Leiden Early Drug Discovery & Development network (LED3) was established by the Leiden Institute of Chemistry (LIC), the Institute of Biology Leiden…