An overview of the research at the Cancer Dug Target Discovery group.

Improving health, enhancing well-being and reducing health disparities across society.

Kathryn Emerson defended her thesis on 28 June 2016

What is the provenance of introduced populations?

How do balanced lethal systems originate and persist in nature?

How does invasive hybridization affect threatened native species?

Does a moving hybrid zone leave a genomic footprint?

More and more medicines are becoming available that target a tumour’s specific traits. The use of chemotherapy is continually undergoing improvement.

Pathways of toxicity

From the 11th of May Ewa Snaar-Jagalska has been appointed Professor in the field of cellular tumor biology within the Faculty of Science at the Institute of Biology Leiden. Her research focuses on the cellular tumor biology and human cancer modeling in zebrafish

What is the most effective way to eliminate tumour cells? The DNA repair mechanism could play an important role in increasing the effectiveness of chemotherapy in the fight against cancerous cells. If we are to influence this mechanism, we need fundamental knowledge about how the mechanism works.

PhD defence

Kyra van der Moezel defended her thesis on 7 September 2016.

Alexander West defended his thesis on 20 May 2021

The Leiden Leadership Centre is an interdisciplinary network organisation branching out from its place within the Institute of Public Administration, Faculty of Governance and Global Affairs (Leiden University in The Hague). The LLC functions as a platform by connecting students, practitioners, and…

The research conducted at the Leiden Academic Centre for Drug Research is clustered within the divisions of BioTherapeutics, Cell Systems and Drug Safety, Medicinal Chemistry and Systems Pharmacology and Pharmacy, and the Metabolomics and Analytics Centre.

Providing each cancer patient with the right treatment remains a challenge. Oncode Accelerator aims to change this by innovating the way we develop cancer treatments, thus ensuring the patient is at the heart of the process. Leiden University, the LUMC and other partners will implement this new way…

Coordination chemistry is the chemistry of metal atoms

Pancreatic ductal adenocarcinoma (PDAC) is the deadliest common cancer, with only 8% of patients surviving for five years. One reason for this poor outcome is that current chemotherapy treatments are highly toxic, often leaving patients too sick to receive treatment or forcing doctors to lower the dose…

Helping cancer patients with treatment choices.

The book offers different theoretical perspectives to help examine the process of public sector reform. In addition it gives an overview of the major trends in the core areas of the functioning of the public sector.

This article explores how employees use leadership behaviours and how characteristics of the organizational context affect their engagement in leadership.

The Egyptian hieroglyphic script was exceptionally versatile, as becomes clear when studying its multiple uses both within Ancient Egypt and beyond its borders.

This dissertation is part of a broader research project that revolves around unraveling the evolution of balanced lethal systems.

In this article, Ben S. Kuipers and Joanne Murphy review recent critiques of leadership theory and practice.

In this thesis, topics relating to the optimization of high-throughput pipelines used for imaging are discussed. In particular, different levels of implementation, i.e., conceptual, software, and hardware, are discussed and the thesis outlines how advances on each level need to be made to make gains…

These are our lecturers (in alphabetical order) for the 2026 Summer School in Languages and Linguistics.

Exploring the application of data-driven AI optimizations, this work leverages past software performance to reduce the carbon footprint and energy consumption of powerful computing applications.

PhD defence

To get a feeling of how we operate at LED3 when it comes to Early Drug Discovery, please browse through our case studies. When you select a case study you’ll find relevant contacts.

In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.

PhD defence

Molecular Physiology is a research group at the Leiden Institute of Chemistry dedicated to the design, synthesis and application of chemical tools to study important biological and biomedical questions. The group is headed by Prof. Dr. Mario van der Stelt and includes the research lines of Assistant…

Our research in the area of safety sciences aims to increase the mechanistic understanding of cellular toxicity of drugs and, in a broader sense, chemicals.

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.

Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska

Cell adhesion signaling

Source: Nature Biotechnology, Volume 2014, Issue June (2014)

Overkleeft

These awards honour researchers who turn scientific insight into real-world impact. From master’s students to postdocs, they highlight exceptional work in life sciences, health sciences, biotech, or environmental health sciences with data science at the core. Meet the 2025 winners.

Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…

Evolutionary and ecological interactions affect species on genetic and phenotypic levels. This theme aims to understand these processes at multiple levels: from molecules to genomes to populations and to communities. Our research focuses on evolutionary responses to anthropogenic change, the role of…

Promotor: E. Bouwman, Co-promotor: S. Bonnet

The majority (80%) of e-waste generated globally are recycled informally in developing countries.

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Metastasis is responsible for over 90% of cancer-related deaths and arises from the ability of a small subset of tumor cells to detach from the primary tumor, overcome multiple biochemical and mechanical barriers, disseminate through the body, and colonize distant organs.

Leiden University commemorates its victims of the war and pays tribute to all members of the university community who resisted injustice.