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Atherosclerosis is the most prominent underlying pathology of cardiovascular disease and an important cause of major adverse cardiovascular events.

The potential of liposomal cancer vaccines

Key publications of the Biologics Formulation group

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

Promotor: W. Jiskoot, Co-promotor: A. Hawe

Cardiovascular disease is the leading cause of death worldwide.

Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius

Animal Sciences’ contributions to the Host-Microbe Interactions research theme focus on the interaction of animal hosts with pathogenic microbes but also the beneficial role of the gut microbiome.

In our globalised economy, goods and services are frequently produced abroad. Is it the producer or the consumer that should be held responsible for greenhouse gas emissions associated with production? Together with colleagues from Berlin, Hauke Ward of the Institute of Environmental Sciences (CML)…

The current COVID-19 vaccination campaign involves injecting the vaccine into muscle tissue, but injecting a smaller amount of vaccine in the skin might also provide good protection. The #wakeuptocorona crowdfunding campaign has enabled Anna Roukens (LUMC) to examine the safety and efficacy of vaccination…

The shift from response to recovery is now noticeable as the world moves past the paralyzing effects of the COVID-19 pandemic. This book explores responses to the pandemic by international, regional, and local institutions, multilateral action, and crisis prevention efforts at different levels of governance,…

The United Nations Office for Disarmament Affairs (UNODA) has published the 2017 issue in their Civil Society and Disarmament series, titled Voluntary, Non-Binding Norms for Responsible State Behaviour in the Use of Information and Communications Technology: A Commentary. The series aims to provide…

The Project “Excellence in science and innovation for Europe by adopting the concept of Responsible Research and Innovation (NewHoRRIzon)” sets out to promote the acceptance of RRI in Horizon 2020 (H2020) and beyond. It will work out the conceptual and operational basis to fully integrate RRI into European…

In this article Vanessa Newby discusses how the ANZUS states of United States, Australia, and New Zealand that sit on the fringes of the Asia-Pacific, are increasingly using their armed forces to deliver Humanitarian Aid and Disaster Response (HADR) as a way of engaging with the region.

Which features characterize speakers’ voices, and how are these features determined by what a speaker is saying?

The history of sign languages of deaf people is severely understudied. The historical linguistics of sign languages offers a fundamentally new perspective on the history of human languages. This project addresses the dearth of knowledge about historical sign language linguistics through a large-scale…

Leiden University was founded in 1575 and is one of Europe’s leading international research universities. It has seven faculties in the arts, humanities and sciences, spread over locations in Leiden and The Hague. The University has over 6,700 staff members and 29,520 students. The motto of the University…

What are we referring to when we talk about ‘good work’? And what does it mean to be a good employer? Helen Pluut and Merel Cornax address these questions in a recently published editorial.

Anyone in Leiden wanting to join a student association has plenty to choose from. But the risk of alcohol abuse is a very real one. Leiden University, Leiden University of Applied Sciences and dozens of student associations have signed a new alcohol covenant that promises they will do their best to…

We have followed the UK referendum of Thursday, 23 June 2016, with great interest and indeed concern.

Physics and Engineering Approaches to Biomedicine and Pharmacology

International organisations that represent collaborations between States are becoming increasingly more powerful, and they have an increasing impact on our daily lives. For example, the European Court of Human Rights in Strasburg established that minors have a right to legal aid immediately following…

In this project we think about the relationship between territory and contagion. Tracing the historical, political, and conceptual linkages between territorial bordering and migration on the one hand and disease related phenomena like contagion, immunity, and inoculation on the other, we ask how the…

Light can be used to apply forces on single cells. Focused lasers have been used by physicists to tweeze particles and to manipulate them. These so called “optical tweezers” can be used as mechanical phenotyping tools for characterising the mechanics of materials and living objects.

With cancer, a person’s body cells grow uncontrollably. Putting together a detailed picture of how this comes about makes it possible to develop efficient therapies. Researchers at the Leiden University Medical Centre (LUMC) and Leiden University are working together to gain a better understanding…

Tuberculosis is a major global health problem caused by the Mycobacterium tuberculosis complex, claiming more than a million lives annually.

The Translational Immuno-Pharmacology group works on translating the efficacy of anti-infective therapy from preclinical (e.g. in vivo) to clinical, and is led by Rob van Wijk. Infectious diseases, such as tuberculosis, are in constant need of new therapies that work better, faster, and with less risk…

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

Dr. Foks obtained this fellowship for the project “Can promotion of efferocytosis induce regression of atherosclerosis?”, in which she aims to identify novel targets to promote regression of atherosclerosis. This research grant allows her to initiate independent research for the next three years.

This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.

The aim of the REACT Study is to examine whether baseline inflammation, and/or neuro-immune responses to stress in a sample of adolescents with experiences of childhood adversity predicts: the perception of stress, social behaviour and general mental and physical health during and after the COVID-19…

The Ghent Rolin-Jaequemyns International Law Institute (GRILI) is a research institute within the Faculty of Law at Ghent University. Founded in 2015 at the initiative of Prof. Tom Ruys, the Institute brings together the existing expertise within the law school in the broader international law domai…

PhD defence

Pharmacologist Amanda Foks is one of the ten talented scientists who received a Dekker grant from the Hartstichting. She receives €427,000 to find a way to rejuvenate immune cells to prevent infarcts. Foks was nominated as Discoverer of the Year in 2016.

An overview of the research at the Biologics Formulation group

At the division of Biopharmaceutics, we aim to develop and test new therapeutic approaches to limit or even prevent the development of atherosclerosis in order to reduce the number of acute cardiovascular syndromes such as myocardial infarction or stroke.

In STAYAHEAD data-intensive approaches are being developed to ”decode the human immunome” with a focus on a global vaccine strategy. They have developed a rapid mass spectrometric test to analyse in real-time large numbers of variants of SARS-CoV-2 and the host immune response, and use these data to…

The Leiden University Medical Center (LUMC) is committed to improving healthcare and the health of individuals. The LUMC staff put this mission into practice on a daily basis with their leading research, cutting-edge teaching and optimal, innovative healthcare.

Yvonne Erkens, Associate Professor Labour Law, was a guest lecturer at the FHR Institute for Higher Education in Paramaribo, Suriname, from 4 to 11 November.

The outbreaks of AIDS and COVID-19 showed clearly how infectious viruses can influence people’s lives. Investigating the changes in the host metabolism may provide a paradigm shift to consider immune-metabolic interactions as therapeutic targets.

Research in the BioTherapeutics research programme is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.

In our HANDS!Lab for Sign Languages and Deaf Studies, we run projects pertaining to sign language linguistics with a focus on Africa. In addition, we are running projects on sign language teaching, tactile signing, deaf people’s experiences with the legal system, and deaf history.