PhD

Tuberculosis bacteria survive by hiding in our immune cells. In her PhD research, biologist Salomé Muñoz Sánchez explores how boosting the body’s own defenses might outsmart this deadly pathogen. Her work reveals two key proteins that help immune cells destroy the bacteria.

Tuesday 27 January - A crisp winter morning and a busy Tuesday. Board matters, research safety, leadership and faculty profiling alternate throughout the day, with a focus on collaboration both inside and outside the faculty. A full day that ends with a game of darts.

Never before has so much research been carried out on the therapeutic effect of psychedelic drugs. Researchers at the LIBC Public Day are happy about the effect the drugs can have on depression, anxiety and PTSS, but at the same time they have some doubts. ‘The hype is bound to crash before long.’

The European PANVIPREP research project started at the Leiden University Medical Center on 11 March. The participants are virologists, biochemists and pharmacists from 14 European countries. Their mission is to develop antiviral drugs to protect Europe during pandemics. At least two such antivirals…

Sabine de Winter

PhD candidate Sibel Bahtiri is one of the new Faces of Science. In videos and blogs, she will show what life is like as a young researcher.

Cancer immunotherapy represents a significant breakthrough in cancer treatment. However, tumors have numerous mechanisms by which they evade destruction by the immune system. It is therefore necessary to decipher and reverse these mechanisms in order to improve immunotherapies.

A variety of age checks are required, both in order to protect children and to ensure that they can participate online, a new study funded by the European Commission finds. The article on the study, co-authored by Simone van der Hof, Professor of Law and Digital Technologies at eLaw, was published in…

For their research many neuropsychologists use the brain scanners at the LUMC. At the start of the pandemic, the rules for visiting the hospital became stricter and a large amount of psychology research looked as though it would fall through. Thanks to good protocols the researchers can now pick up…

Piercing through the skull with an ice pick, administering electric shocks without an anaesthetic, or applying leeches to the uterus: these may seem like medieval methods of torture, but they are in fact therapies used in medicine. Willem van der Does writes about all of them in his new book. ‘Physicians…

Matthias Flór receives the KHMW Graduation Prize in Theoretical Physics for his master's thesis. His research on exotic superconductors at Leiden University and TU Delft struck a chord with the jury. The jury unanimously chose to award Flór noting that ‘he demonstrated impressive technical abilities…

In a new study published in PLOS One, Leiden archaeologist Anastasia Nikulina, together with an international team from France, Denmark, the United Kingdom and the Netherlands, challenges the long-held belief that early humans had minimal impact on their environment before the rise of farming.

The ROBUST consortium, which is the initiative of the Innovation Center for Artificial intelligence (ICAI), has received 25 million euros from the Dutch Research Council (NWO) to strengthen fundamental AI research.

Do you often feel drained after a day at the office? The new SPS Monitor measures how sensitive you are to various stimuli. Psychologist Véronique de Gucht developed the questionnaire. 'I want to demystify high sensitivity.'

Open, extravert, agreeable, stress-tolerant and conscientious. These are the character traits of surgeons according to research by the LUMC.

Astronomers and surgeons from Leiden are collaborating with industry to develop an optical instrument that delivers faster, more accurate imaging of tumour tissue and abnormal blood flow during surgery.

Technological innovations such as home dialysis could significantly improve the quality of life and health of kidney patients. Professor Joris Rotmans therefore wants to continue pushing for new medical technology, as he will explain in his inaugural lecture on 24 March.

Leiden University will continue to offer its BA in Italian Language and Culture. The Board of the Faculty of Humanities has reversed its decision to stop admitting new students as of the 2026/2027 academic year.

‘AI can’t do half as much as people think,’ says computer scientist and psychologist Roy de Kleijn. He tries to teach robots seemingly easy things, and keeps on discovering how smart human intelligence really is. Three things that computers are no way near doing.

Biologist Nataliia Machushynets felt like she was ‘looking for a needle in a haystack’, trying to find new antibiotics to help solve the problem of resistance. During her PhD research, she did find what she was looking for, in the soil beneath our feet.

Genetically modified organisms (GMOs) could be useful allies in the fight against critical environmental problems. Could because the use of GMOs is strictly regulated at the moment. A Leiden student team is now trying to make these GMOs safer with the aid of an ingenious lock.

A CT scanner to treat eye cancer, energy-efficient software for the future and a test to identify male chick eggs. Three projects by researchers from Leiden University are to receive funding from research funder NWO’s Open Technology programme, to which the business sector also contributes.

What if AI doesn’t just support engineers, but actually works alongside them? A large consortium, including Leiden University, gets 3.7 million euros. They will explore novel synergies between engineers and AI, in industrial engineering design areas such as automotive engineering.

Castles, monasteries and bridges, but also city profiles, history prints and water management works. Leiden University Libraries (UBL) manages one of the most important collections of topographical images in the Netherlands. The collection, bequested to UBL by Johannes Tiberius Bodel Nijenhuis (1797-1872)…

For new managers, the dynamic university environment can be a lot to contend with. A special induction programme comprising an online module, an introduction meeting and peer consultation will help you find your way.

With the appointment of Dennis Janssen as operational director at the end of last year, the management team at the Observatory is now complete. Janssen has been working at the university for over twenty years, but the faculty and the Observatory are new to him.

The Graduate School of Science starts 2024 with a new Dean. The Faculty Council appointed Erik Danen for the coming four years. He succeeds Eric Eliel, who has held the position since May 2020.

On the 8th of March the first "introduction to entrepreneurship" boot camp was held at PLNT specifically for PhD researchers at the LACDR. During the two hour block topics such as "the core of entrepreneurship", "spotting opportunities" and "what is your value proposition" were discussed.

PhD candidates Mohammed Saleh and Berfin Gülave (Division of Systems Pharmacology and Pharmacy) published their research paper on “Using the LeiCNS-PK3.0 Physiologically-Based Pharmacokinetic Model to Predict Brain Extracellular Fluid Pharmacokinetics in Mice”.

On March 24, 2025, World TB Day, we (Annemarie Meijer (IBL), Matthias Barz (LACDR), and Simone Joosten (LUMC) hosted the symposium „A Dutch Perspective on Mycobacterial Infections“, which brought together the Dutch scientific community working on mycobacterial infections.

During the LACDR Fall Symposium, Daan Jiskoot received the annual Suzanne Hovinga Award for the best master thesis. Daan performed his Research Project 2 at the University of California, Irvine at the Prof. David Mobley lab, supported by LACDR supervisor Willem Jespers. The in silico determination of…

Prof. dr. Douwe Breimer, emeritus Professor of Pharmacology, former Rector Magnificus and founder of LACDR has established a foundation to stimulate, support, and promote scientific meetings in the field of Pharmacology. Particularly those concerned with fundamental research and mathematical modelling…

From self-driving cars to innovative drug development, artificial intelligence (AI) is going to fundamentally change our lives in a variety of ways.

On Thursday the 9th of December the LACDR Fall Symposium 2021 took place. Although the plan was to organize this symposium physically, unfortunately this was not possible due to the corona measures and it became an online event.

During the LACDR Fall Symposium, Niek Kijk in de Vegte received the annual Suzanne Hovinga Award for the best master thesis. Niek performed his RP1 research under the supervision of Dr. Natalia Ortiz Zacarias and Prof.dr. Laura Heitman in the Molecular Pharmacology group at the Division of Drug Discovery…

The whole world is waiting anxiously for sufficient supplies of coronavirus vaccines. As Launch Navigator at Pfizer, alumnus Dennis de Mik must help ensure that the Netherlands receives 19.8 million doses of the Pfizer/BioNTech vaccine. How is he going about this and how has his Bio-Pharmaceutical Sciences…

Fantastic plants, dizzying patterns and pulsating sounds: researchers from Leiden are going to study the effects of a simulated psychedelic trip on the mind and body at Lowlands Festival. Why might this be interesting for therapies?

Leiden researchers have developed a groundbreaking model to advance cancer immunotherapy. Using a 3D printer, they create mini-tumors within an environment that closely mimics human tissue. They have also developed a method to monitor real-time interactions of these mini-tumours with immune cells during…

Herman Spaink knows of many substances that may help combat tuberculosis. Lab space to study them safely is very limited in Leiden. A brand-new lab at Universitas Gadjah Mada in Indonesia will soon provide a solution. About time, says Spaink, ‘The disease is on the rise and is becoming less sensitive…

Studying how single DNA molecules behave helps us to better understand genetic disorders and design better drugs. Until now however, examining DNA molecules one-by-one was a slow process. Biophysicists from Delft University of Technology and Leiden University developed a technique that speeds up screening…

Hans Ulrich Scherer is Professor of Rheumatology, in particular Translational Rheumatology. He wants to build bridges between research and clinical practice and between departments and organisations at home and abroad. Scherer will give his inaugural lecture next Friday. ‘To make progress, we have to…

Due to the increasing resistance to certain antibiotics, the life-threatening condition sepsis is becoming harder to treat. For her PhD project, Leiden pharmacologist Feiyan Liu used mathematical modeling to find out how antibiotics can be used more effectively to cure sepsis.

Bacteria whirl around in the mouths of most people, forming dental plaques and sometimes causing nasty gum infections. Treponema denticola might be a dangerous pathogen, but not much is known about this bacterium. It was up to Ariane Briegel and her research group to change that.

The steady decline in lethal gun violence in the EU came to halt in 2012 and some countries, such as Sweden, have even noticed an increase since then. An arms race among drug criminals and an increase in the availability of illegal firearms could lead to more criminal and gun violence. This is one of…

As many as seven first-year students from the Faculty of Science were honoured as young talents. In addition, the Royal Holland Society of Sciences and Humanities (KHMW) also lauded three master's students and an astronomy project during a vibrant ceremony on 28 November. Professor of Science Communication…

Smart drug carriers, uneven cosmic expansion, and solar energy storage in molecules. These are the topics of three newly awarded NWO-XS grants to researchers at the Faculty of Science.

Gerard van Westen has received the KNCV Gold Medal, the most important Dutch award for chemists under 40. 'It's a huge honour,' says the professor of AI and medicinal chemistry. 'I am now part of the group of people I was always impressed by.'

Before researchers can develop targeted drugs, they need to know exactly how a disease works. Biochemist Bert Beerkens created molecules that allow them to find out. He used caffeine as the basis for new molecules that enable research into certain receptor proteins on cells.