About nine million people worldwide contract tuberculosis each year. Research into new treatment for this disease has received fresh stimulus with more efficient techniques and a new understanding of how the tuberculosis bacteria works.

Metabolomicshas emerged as an important discipline to study molecular and cellular processes in living cells and organisms with the ultimate aim to obtain an answer to a given biological/clinical question.

Optimization tasks in practice have multifaceted challenges as they are often black box, subject to multiple equality and inequality constraints and expensive to evaluate.

Promotor: Prof.dr. J.N. Kok, Co-Promotor: W.A. Kosters

This article argues that opposition to government green investments is conditional on the method of financing.

Dendritic cells (DC) play a prominent role in the priming of CD8(+) T cells. Vaccination is a promising treatment to boost tumor-specific CD8(+) T cells which is crucially dependent on adequate delivery of the vaccine to DC.

Promotores: J.N. Kok, H.J. Hoogeboom

Twenty years from now, the world population is estimated to be around 8.7 billion people, compared to the current 7.3 billion. In combination with the improvements in living standards and the corresponding growth in consumption, this will result in an enormous increase in the demand for food, consumables,…

Artificial intelligence could help make the work of public sector organisations, professionals, policy- and decision makers more effective, more efficient, and ideally could make it more rationalised and evidence-based.

Plants and their pollinators form complex interaction networks. Within these networks, species differ widely in the number of species they interact with.

Poly(lactic-co-glycolic acid) (PLGA) particles have been extensively studied as biodegradable delivery system to improve the potency and safety of protein-based vaccines. In this study we analyzed how the size of PLGA particles, and hence their ability to be engulfed by dendritic cells (DC), affects…

What political factors affect the speed or duration of EU legislative decision-making?

The increasing competition in the automotive industry requires the tailored, swift development of technologically sophisticated vehicles. Therefore, the computationally expensive state-of-the-art simulation technologies are combined with optimization algorithms. An example of a real-world optimization…

Promotor: Prof.dr. E. Deprettere

In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.

This thesis investigated miniaturized mass spectrometry (MS)-based analytical methods to address challenges in analyzing biomass-restricted biological samples.

The development of new environmentally sound technologies is seen as a key route towards achieving sustainability.

Organic amendments applied to agricultural fields can partially offset our carbon emissions to the atmosphere and improve the resilience of agriculture to the effects of climate change. Driving these benefits, however, are complex and poorly understood interactions between organic amendment properties,…

Understanding DNA repair mechanisms is essential for advancing plant biotechnology and crop improvement. This study investigates how double-strand breaks (DSBs), induced by CRISPR/Cas systems, are repaired in the model plant Arabidopsis thaliana, and how these processes influence Agrobacterium tumefaciens…

This dissertation consists of two parts, each of which considers a different research area related to random interval maps. In the first part we are interested in random interval maps that are critically intermittent.

Radiography is an important technique to inspect objects, with applications in airports and hospitals. X-ray imaging is also essential in industry, for instance in food safety checks for the presence of foreign objects.

This research delves into the unique cultural approach of the Tenggerese people, an Indigenous community in East Java, Indonesia, regarding elderly care. It focuses on their traditional practices of bakti (‘filial piety’) and sayan (‘mutual aid’), deeply ingrained in the community's lifestyle and va…

Cyber security is one of the critical challenges in our inter-connected world. Organizations are being constantly targeted by adversaries. Various critical systems become exposed on the Internet. Users can find that their data has been stolen from a company that they were not even aware of.

Promotor: K.J. Batenburg

Promotor: Prof.dr. G.P. van Wezel, Co-Promotor: E. Vijgenboom

Reducing greenhouse gas emissions is one of the most pressing challenges that humanity faces in the coming decades.

Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…

Urbanization brings benefits like housing and jobs but also challenges like biodiversity loss. CML's Urban research program uses science to create sustainable cities, focusing on the built environment (circular economy, urban mining) and enhancing urban nature for biodiversity and human benefits.

Huub de Groot is professor in Biophysical Organic Chemistry. With his team he works in the field of photosynthesis and artificial photosynthesis. The molecular basis for photosynthesis is formed by protein complexes and organelles that contain chlorophyll molecules. The antenna systems herein capture…

SuperCode: Sustainability PER AI-driven CO-DEsign

Optimally solving real-world expensive Black-Box Optimization (BBO) problems w.r.t. real-world constraints, such as wall-clock time and computational costs, is extremely difficult and tedious.

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

This thesis is dedicated to the exploration of the primordial dark ages: unknown physics during the earliest stages of the Universe’s expansion that have not yet been directly probed by observations. Cosmic inflation is a burst of exponential expansion of space after the “Big Bang”.

Can Cyanobacteria be engineered to convert the greenhouse gas carbon dioxide into the valuable chemical isoprene?

Agrobacterium-mediated transformation (AMT) has abundantly been used for scientific research for identifying valuable traits.

Artificial photosynthesis has recognised potential to produce green and sustainable fuels from earth-abundant resources such as water, carbon dioxide (CO2), and sunlight.

Advances in the field of high-performance Nd-Fe-B permanent magnets, by re-engineering their microstructure to make them more powerful while reducing rare earth content.

Circularity is an essential aspect of the industry transformation towards resource-efficiency, climate neutrality and long-term competitiveness. It can produce substantial material savings along value chains and production processes, generate added value and unlock economic opportunities.

This thesis studies theoretical surface chemistry within the field of heterogeneous catalysis.

This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.

Promotor: H.W. Lenstra

Are you planning to conduct clinical research in the Netherlands? In this online course, you are introduced to legislation and procedures on clinical research in the Netherlands. It will help you prepare and submit your research file efficiently. The first three themes ‘The Dutch Review System’ , ‘The…

A high performance computer or supercomputer owes its massive processing capacity to the fact that it chops a single overarching task into a whole series of smaller tasks. It simultaneously tackles each of those smaller problems.

Researchers at LIACS are working to devise the computers of tomorrow that will be the backbone of the Cloud and Edge computing paradigms as well as the Internet of Things. In this respect, we are involved in research and development of high performance computing systems, embedded & real-time computing…

The Biomedical Microscale Analytics group is led by Dr. Rawi Ramautar. In present-day metabolomics, and bioanalysis in general, the analytical toolbox used encounters difficulties for the analysis of limited amounts of biological samples. As a result, a significant number of crucial biomedical/clinical…

In the Department of Business Sciences, three chairs are established. Together, the chair holders lead the Turnaround, Rescue & Insolvency Leiden Research Team (TRI Leiden), which consists of legal and business science researchers from Leiden Law School. TRI Leiden aims, through an international and…

Netwerk en projecten duurzaamheid verduurzaming green office en green team

In this thesis, the researcher developed a nanosystem based on the metallophilic Interaction between cyclometalated complexes.