In theory, states can gain security by acquiring internal arms or external allies. Yet the empirical literature offers mixed findings: some studies find arms and allies to be substitutes, while others find them to be complements. Political scientists Matthew Digiuseppe (Leiden University) and Paul Poast…

Proceedings of the 25th International Congress of Roman Frontier Studies 2

The project will support Responsible, Research and Innovation (RRI) policy experiments in the healthcare sector in three European territories: in Murcia (ES), Örebro (SE) and the Republic of Cyprus (CY). CHERRIES will engage the territorial stakeholder ecosystems in participatory agenda setting, need…

In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…

This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.

This project aims to explore and examine the factors that impact upon the efficacy of information disclosure duties pertaining to customer data use in online business.

Vaccination is the most effective method to prevent influenza infection. However, current influenza vaccines have several limitations. Relatively long production times, limited vaccine capacity, moderate efficacy in certain populations and lack of cross-reactivity are important issues that need to be…

Arco Timmermans’ handbook unites experts to examine public affairs, its challenges, and its alignment with democracy and open society.

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

PhD defence

PhD defence

Political scientists Huib Pellikaan and Niels van Willigen (Leiden University) use and elaborate on the theoretical insights from game theory in order to understand nuclear security in changing environment. Now that the relations between the US and Russia have deteriorated and smaller nuclear states…

Although science and education have top priority, exploratory projects with companies, governments and NGOs generate ample opportunities in terms of societal challenges, science strategy, valorisation and research collaboration. In the LIACS Applied Data Science Lab, our master's students and graduates…

This monograph focuses on clustering of objects in high-dimensional data, given the restriction that the objects do not cluster on all the attributes, not even on a single subset of attributes, but often on different subsets of attributes in the data.

The article offers a comparative systematic literature review of the principles, norms, and strategies associated with Security by Design and Privacy by Design

How did interests outside the scope of the Dutch chartered trading companies influence the career-paths of Dutch colonial governors?

With an emphasis on developing novel miktoarm star polymers termed PeptoMiktoStars, this thesis leverages asymmetric polymeric polypept(o)ide frameworks to advance their effectiveness in delivering hydrophobic drugs and nucleic acids.

Patients share valuable advice and experiences with their peers in online patient discussion groups.

Principles of Environmental Sciences provides a comprehensive picture of the principles, concepts and methods that are applicable to problems originating from the interaction between the living and non-living environment and mankind. Both the analysis of such problems and the way solutions to environmental…

This open access volume surveys the state of the field to examine whether a fifth wave of deterrence theory is emerging. Bringing together insights from world-leading experts from three continents, the volume identifies the most pressing strategic challenges, frames theoretical concepts, and describes…

The mission of the Plant Science research programme is to contribute to the sustainable production of high quality crops, flowers and high-value bio-based products. This is realised by generating fundamental knowledge of basic biological processes related to development of plants and their interaction…

Just like every other organism on Earth, plants’ ultimate goal is to survive and reproduce. In order to achieve this, they must make trade-offs between where and how to allocate their finite set of resources. Whether they put their resources and energy into their growth, reproduction or maintenance,…

Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…

In The Agency of Empire: Connections and Strategies in French Expansion (1686-1746) Elisabeth Heijmans places directors and their connections at the centre of the developments and operations of French overseas companies.

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

Promotores: G. Persoon, R. Schefold

Three at the same time: a ligation strategy combining tetrazine–norbornene cycloaddition, Staudinger–Bertozzi ligation, and copper(I)-catalyzed click reaction was used to label the three catalytic activities of the proteasome simultaneously in a single experiment. The orthogonality of the three ligation…

In this article, Tom Buitelaar proposes a systematic framework for analyzing the impact of individual characteristics of peacekeeping leaders on the behaviour of field-level personnel in UN peacekeeping operations.

On February 20th, Gulnaz Sibgatullina succesfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Gulnaz on this great result.

Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…

Promotor: Prof.dr. T. Hankemeier, Co-promotor: R.J. Vreeken

CML report 192

PhD defence

The CS-NL network is a vibrant and active community of Citizen Science practitioners, initiators, researchers and participants from across all corners of society (Academia, Industry, Government, Civil Society, and Citizens) who come together to share knowledge and know-how for participatory research…

Many Western defence strategies concentrate on maintaining the status quo. Actively promoting universal values can also be a good strategy for resilience, according to Theo Brinkel, Professor by Special Appointment in Military-Social Studies. Inaugural lecture 15 January.

Is it possible to formulate a new conceptual foundation for attributing an evaluative role to historiography of science, without relinquishing the historiographic sensitivity of recent work in the discipline?

How can we bridge the gap between experts and the general public?

Corporate R&D organizations and their relation to academic laboratories.

The overall objective of ECS is to widen and strengthen the European Citizen Science community through capacity building and awareness raising activities such as the creation of a European Citizen Science Academy and the establishment of a network of 28 ECS Ambassadors.

PathOS aims to contribute to a better understanding and measurement of Open Science impacts and their causal mechanisms. This is pivotal in order to develop effective OS policy in the EU (European Union). It will do so by collecting concrete evidence of OS effects, by studying the pathways of OS practices,…

The research programme Statistical Science is concerned with the analysis and interpretation of masses of data, the quantification of uncertainty using probability models, and the development and benchmarking of algorithms and methods with these aims.

BE-OPEN is a structural project funded under the Erasmus+ Capacity Building in Higher Education action. The project is coordinated by the University of Novi Sad, Serbia. The main objective of the project is to develop conditions for the implementation of the core principles of Open Science at universities…

Dutch knowledge institutions are taking steps to recognise and reward open science. On 13 December, the Open Science NL Steering Board approved a total of 1.2 million euros in grants to 23 institutions. The Centre for Science and Technology Studies (CWTS) leads the national coordination of the local…

We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.

In the research programme Microbial Sciences we perform state-of-the-art research in the field of biotechnology and microbial sciences.

Scientific director Herman Spaink brought almost all scientific staff members of our institute together in Noordwijkerhout for a two-day meeting about strategies for the future.