According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

Researchers at LIACS are working to devise the computers of tomorrow that will be the backbone of the Cloud and Edge computing paradigms as well as the Internet of Things. In this respect, we are involved in research and development of high performance computing systems, embedded & real-time computing…

Mathematical models of software systems enable characterizations, abstractions, simulations, and analysis of complex software during its development.

The correctness of computational systems is of great importance to our society, since it becomes ever more reliant on the benefits of computing.

Making systems biology modelling a central pillar of research in biology

How do balanced lethal systems originate and persist in nature?

Researchers at LIACS are working to devise the computers of tomorrow that will be the backbone of the Cloud and Edge computing paradigms as well as the Internet of Things. In this respect, we are involved in research and development of high performance computing systems, embedded & real-time computing…

Students in Leiden are entitled to good teaching and good supervision. For their part, there are some conditions they have to meet to ensure that they complete their studies within the time allotted.

Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris

This book is about the workings of networks of the mobile in Africa, a continent usually associated with the ‘global shadows’ of the world.

Why does one person radicalize to involvement in terrorist violence within a group-based context, while another engages in this form of violence alone?

Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.

Promotor: E. F. van Dishoeck, Co-promotor: C. Walsh

Search and conversational systems have become central to how people access information and perform tasks.

Understanding others’ emotional behavior is essential for navigating daily social life. But how is such an understanding achieved? The eye-tracking study by Yung-Ting Tsou and colleagues shows that children with hearing loss adopt a unique visual strategy that makes uses of explicit visual information…

Across many decision-making tasks, people and animals systematically repeat (or alternate) their choices - even when the choices they make are intrinsically uncorrelated. This phenomenon (also known as 'sequential effect' or 'choice hysteresis') has been known for at least a century, and may be a stable…

This thesis provides explicit expressions for the density functions of absolutely continuous invariant measures for general families of interval maps, that include random maps and infinite measure transformations, not necessarily number systems.

The master's specialisation Bioinformatics at Leiden University focuses on research, development and application of computational tools and approaches for expanding the use of biological, medical, behavioral and health data.

Interaction between Legal Systems acknowledges that law-making and law enforcement are increasingly taking place on various levels: in a global context, in EU context, on a national level and in a private law framework. These levels influence each other, sometimes directly, on the basis of a hierarchical…

In condensed matter systems electron-electron interactions, negligible in everyday metals, can dramatically alter the electronic behavior of the system. Examples of such altered behavior include high-temperature superconductivity and modulation of the electron density.

This thesis studies operator-algebraic aspects of subproduct systems, a generalization of product systems of Hilbert spaces.

The ambition of the Medical Systems Biophysics and Bioengineering group led by Alireza Mashaghi is to develop and use physics and engineering concepts and tools for pathophysiology, diagnostics and therapy.

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

Drug development critically depends on preclinical models that mimic human physiology, yet traditional two-dimensional cultures and animal models often lack predictive power.

The research groups within the biological, soft and complex systems research area study the physics of a broad range of biological and soft materials. This spans both experimental and theoretical research.

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

Grammatical gender is famously the most puzzling of the grammatical categories. We have a solid typology of gender systems, yet exciting and unexpected patterns keep turning up which defy easy classification and straightforward analysis. Some of these question, stretch or threaten to cross the outer…

We study the physics of a broad range of biological and soft materials

This book explores the boundaries of the category of gender and their theoretical significance within the framework of Canonical Typology.

At Leiden University we believe it is important that you receive the right kind of support in your choice of study and while you study. This is why we use what we call the ‘Leiden study system’ to help you make a success of your study from start to finish.

The research within the Division of Cell Systems and Drug Safety, headed by Prof. Bob van de Water, is focused on novel therapeutic modalities and novel concepts in early drug discovery, in order to develop more effective and safer therapeutic strategies. We generate advanced cell and computational…

How citizens and professionals are the key to successful collaboration in the delivery of public services. How do individual characteristics of citizens and professionals influence citizen-professional collaboration in the co-production of public services?

Isis on the Nile. Egyptian gods in Hellenistic and Roman Egypt

Promotores: Prof.dr. J. Aarts, Prof.dr. J.M. van Ruitenbeek

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

For present purposes, it is important to distinguish between an early period of settlement, about 6800-6200 BC, and a late period, about 6200-5800 BC, at Tell Sabi Abyad.

The work presented in this thesis addresses the role of the locus coeruleus (LC) - norepinephrine (NE) system in various aspects of human cognition, and the modulation of brain state.

In this thesis, we study travelling waves in stochastic reaction-diffusion equations. We extend techniques from the deterministic theory for travelling waves to apply to the stochastic version, which allows us to compute the stochastic wave speed and shape, and draw conclusions on the stability of the…

Promotores: F.H.J. Redig, W.T.F. den Hollander

All the data stored and processed by our computers is encoded as sequences of zeros and ones, called bits. Quantum computers offer an alternative to this traditional way of encoding and manipulating information.

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…

DIGIFOOD is a transnational research project that investigates how data governance can support equitable and sustainable digital food systems. Around the world, digital technologies are transforming agriculture. Sensors in soil, satellites in space, and mobile phones in farmers’ hands are generating…

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.