On 12 March 2021, Armin Cuyvers spoke on the issue of Euroscepticism and EU democracy post-Brexit in the multidisciplinary Winter School on Sustainable Global Futures: Knowledge, Democracy and Global Communications.

Marta Fiocco, professor at the Mathematical Institute, has received a grant for predicting survival outcome and improving the balance between prognosis and quality of life for soft tissue sarcoma patients (Personalised Sarcoma Care).

In the research programme Drug Discovery & Safety, we are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.

A new technique using fluorescent imaging to track the actions of enzymes might aid drug design for new anti-cancer, inflammation and kidney disease treatments. Researchers at the University of York and Leiden University have published these findings in Nature Chemical Biology.

Chemotherapy that does nothing until you irradiate it with light. Sylvestre Bonnet receives a Vici grant of 1.5 million euros for the development of this treatment. The Leiden chemist wants to build a new molecule to fight tumours that are at the time still difficult to treat.

Will British universities become isolated after Brexit? The University of Oxford has set up a new programme for excellent young researchers to try to prevent that happening. Two Leiden PhD candidates are taking part. 'We have lost a lot of the citizens of Europe.'

In the days following Christmas, Christa Tobler gave a series of interviews to Swiss newspapers and Swiss radio about the new Trade and Cooperation Agreement between the EU and the UK and about what it might mean for Switzerland-EU relations and the draft EU-Swiss institutional framework agreement.

An international group of scientists has discovered that certain cells of our immune system – the so-called T cells – communicate with each other and work together as a team. To fight an infection they stimulate each other’s growth, but at the same time, they inhibit each other when there is a surplus…

When you think of physics, do you think only of complicated formulas? You’re not the only one. Therefore, every year, the Leiden Insitute of Physics organises the LION Image Award to show another side of physics: beautiful images about intriguing science. The winner of the 2022 photo competition captured…

Leiden researchers have developed a groundbreaking model to advance cancer immunotherapy. Using a 3D printer, they create mini-tumors within an environment that closely mimics human tissue. They have also developed a method to monitor real-time interactions of these mini-tumours with immune cells during…

On 11 November Professor of Gastroenterology and Hepatology, Monique van Leerdam will deliver her inaugural lecture entitled, ‘Aiming for Prevention’. Van Leerdam, who specialises in hereditary tumours, was appointed professor in July 2020. In her inaugural lecture she will discuss the importance of…

Patients with incurable cancer want their oncologist to be clear but to show empathy too. They find hard and vague communication harmful. These are the results of a study by psychologists from Leiden that has been published in the American journal Cancer.

Liposomes hold great promise for peptide-based personalized cancer vaccination, especially when administered intradermally. However, current liposome preparation methods are very time consuming (resulting in long development times per formulation), whereas personalized cancer vaccination requires very…

The advanced insights obtained for the CNS PBPK model development are currently used to develop advanced mathematical models for drug distribution prediction in other body tissues protected by barriers, such as the gut. The gut PBPK model will be linked to drug effects for treatment of colon cancer.

This project is funded by the Dutch Cancer Society. The project will be part of an ongoing research line aimed at identifying mechanisms of cancer therapy resistance and metastasis. In this project, it will be investigated how the Grainyhead family of transcription factors controls therapy response…

PhD defence

In 2013, Sylvestre Bonnet received an ERC Starting Grant to kill cancer with molecules that can be activated by light. Two postdocs and three PhD students later, the end approaches of his so far successful project.

On Wednesday the 30th of November, International Business Law celebrated its fifth anniversary together with students of the study association SBR (also celebrating their fifth anniversary), lecturers, alumni and staff members. The event mainly revolved around the question of what Brexit will imply…

On 15 September Armin Cuyvers lectured on the legal challenges surrounding Brexit for the The Academy for Legislation, the most important educational institute for legislative lawyers in the Netherlands.

Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.

We are interested in understanding the mechanics of soft materials, of which biological materials are prominent examples.

Intrigued by the way cells autonomously regulate their fate, we strive to understand and visualize cellular processes as the basis of Cell Signaling.

Following the European Union membership referendum in the United Kingdom on 23rd of June 2016 and its result, Brexit has turned into a theme dominating public discussion in Europe and beyond. The vote of the people of the UK to leave the EU represents an unprecedented episode in the history of European…

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

Projects within the theme ‘Computational Biology’ aim to employ mathematical or computational dynamical modelling approaches to discover novel concepts that are important for drug development.

Recently, Joris Larik, Assistant Professor at Leiden University College (LUC) of Leiden University, talked about the legal aspects of Brexit on Al Jazeera, as the United-Kingdom is trying to break national law during the Brexit negotiations. Could there be penalties for the United-Kingdom?

Researchers from the Leiden University Medical Center (LUMC) have developed an AI model that accurately predicts the risk of endometrial cancer recurrence.

When the immune system attacks cancer, the tumour modifies itself to escape the immune reaction. Researchers at LUMC published on this subject in Nature on 28 June.

Seven talented female scientists join the fight against cancer of the Oncode Insitute. Laura Heitman of the Leiden Academic Centre for Drug Research is one of the new Junior Investigators. ‘I hope to discover new druggable targets’.

The year 2020 should finally be Brexit year. The United Kingdom is set to leave the European Union on 31 January, at midnight Dutch time. Legal scholar Joris Larik from Leiden University College The Hague explains why he is not advocating remain.

Thanks in part to the persistence of a Leiden research group, cancer could be detected in the near future with just a single drop of blood. Not only can the diagnosis be determined at an earlier stage, but the blood test is also cheap, fast and patient friendly. The first results of this method seem…

Leiden researchers have carried out successful tests using a new method of packaging a cancer vaccine in nano-particles. The new vaccine has induced a strong immune reaction in mice. The researchers believe that this method can make an important contribution to the treatment of cancer. Their findings…

On Monday 28 June 2021, a text based on an interview with Christa Tobler appeared in the Hofvijver (Montesquieu Instituut) on the relationship between the European Union and Switzerland, in particular after the decision of the Swiss Federal Government to refrain from signing an agreement on institutional…

Waarom laaien er rellen op in het Verenigd Koninkrijk, aangespoord door de extreemrechtse British Defence League? Jorieke Manenschijn sprak met EenVandaag over hoe de beloftes van Brexit aan de woede hebben bijgedragen.

Researchers at the Leiden Institute of Advanced Computer Science (LIACS) are collaborating on the development of a conversation tool for patients with breast, prostate and skin cancer. The aim is to create a conversation tool that can support cancer patients in their care and help them make decisions.…

Predicting cancer survival with machine learning, that is the aim of a new collaboration between the Mathematical Institute, the European Organisation for Research and Treatment of Cancer (EORTC) in Brussels and Leiden University Medical Center. The focus of this project is to characterise the model…

Aukje Beers combined theory and practice, as well as chemistry, biology, and computer models. In this way, she discovered two protein inhibitors during her master’s project that could contribute to the development of a new cancer drug. For her research, Beers received the Unilever Research Prize on…

How do you know if a drug will actually work? The Leiden-based spin-off Omivera is developing a new technology that could provide clearer answers. The young company received a seed investment from the investment fund UNIIQ to support its development.

Providing each cancer patient with the right treatment remains a challenge. Oncode Accelerator aims to change this by innovating the way we develop cancer treatments, thus ensuring the patient is at the heart of the process.

Professor of Cardiothoracic Surgery, in particular pulmonary surgery, Jerry Braun will give his inaugural lecture on Friday 23 September entitled ‘Out of countless millions’. Braun has been a professor and acting head of the LUMC’s Department of Cardiothoracic Surgery since January 2020. Covid meant…

On 12 July, a workshop was held in hybrid format (on site and online) at the University of Reading in the UK on the subject of 'EU law teaching in the UK post-Brexit: Learning from EU law colleagues based in other non-EU states and seeking UK solutions'.

The goal of the research presented in this thesis was to explore the chemical space of ruthenium(II) photocages, investigate their ability to host potent chemotherapy drugs, and to red shift the activation wavelength of the most promising PACT candidates to conduct biological studies.

To develop good cancer treatments, we need to know much more about how malignant tumour cells develop. Professor Ewa Snaar-Jagalska looks at not just the effect of medication on isolated cells but also the behaviour of cancer cells in their tissue environment. Inaugural lecture on 11 December.

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

One in two people will be diagnosed with cancer. World Cancer Day on 4 February raises awareness of the impact of this devastating disease. Leiden University is conducting various studies aimed at preventing and controlling cancer. Below are just a few examples.

Chemotherapy that does not harm the body, but effectively fights cancer cells: that is the goal of chemist Sylvestre Bonnet and his team. During his PhD research, chemist Xuequan Zhou brought that goal a little closer. He developed molecules that, upon injection in the bloodstream, self-assemble into…

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

'We believe that developing a protocol to help people fight cancer is extremely valuable, given that cancer is such a prevalent and devastating disease. If you believe so too, you can support us in realising this mission.' Master's student in Psychology Saskia Heijnen starts crowdfunding to make her…

Cancer research generates massive amounts of data, but traditional tools often fail to fully harness their potential. How can we unlock this data to provide better treatments for cancer patients? PhD candidate Marina Gorostiola González explored this by using advanced data analysis techniques to guide…

Actin and microtubules form cellular cytoskeletal network, which mediates cell shape, motility and proliferation and are key targets for cancer therapy. Changes in cytoskeletal organization correlate with proliferative capacity and invasiveness of cancer cells. These changes expectedly lead to altered…