The Computer Systems, Imagery & media (CSI) research programme performs research on methods and techniques for the design, implementation and application of advanced computer systems, in particular parallel, distributed and embedded computer systems.

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.

Promotor: T. Schmidt

This paper describes two synthetic lipid models designed to replace human stratum corneum (SC) in studies of the impact of volatile organic chemicals on the molecular organization of the skin barrier lipids.

Promotor: Prof.dr. E. F. van Dishoeck, Co-promotor: A. N. Heays

The study of orchid flowers, fruits, and inflorescences is crucial due to the remarkable diversity of orchid species and their unique adaptations to pollinators and seed dispersers. However, our understanding of the evolution and development of these organs within the orchid family remains limited.

At the Leiden Curious Minds Centre, our research focuses on the relationship of exploratory behaviour and discovery learning to curiosity and the way children regulate their behaviour and emotions. We want to improve our understanding of how children can and do become more and more the captain of their…

How do people develop and how do they learn? How does their environment affect them? How do we ensure that they develop in optimal fashion? And what can we do if problems occur? These are questions that the researchers at the Institute of Education and Child Studies try to answer.

This longitudinal study is focused on neurodevelopmental problems in young children with XXY, XXX and XYY, aged 1 to 6 years.

PhD defence

Erik Danen is looking at how to inhibit tumours that do not respond well to medicine – and he is making some headway. The Professor of Cancer Drug Target Discovery studies the interaction between tumour cells and their surroundings. Inaugural lecture on Friday 10 May.

Developmental considerations in the design and delivery of cognitive-behavioural therapy for adolescent school refusal

Biological and behavioural measurements of parent-child interactions.

Across cultures, parents help their children master the social and linguistic codes needed in adult life. Recent research on language socialization found important cross-cultural differences, pointing out the need for more diversity for a full understanding of this process.

In the Netherlands, levying tax on inheritances at death has been a fact of life for centuries. The presumed double taxation and its sad precursor are elements of the discussion about the levy of this inheritance tax, but so too are the possibilities to reduce the tax through ingenious legal constru…

In 2008, the intervention ‘Denken + Doen = Durven’ (Think + Do = Dare) was developed in the Netherlands (Bögels, 2008). This is a cognitive behavioral therapy program for children and young people between the age of 8 to 18, diagnosed with an anxiety disorder. The intervention is given by a professional,…

Why do children with an Autism Spectrum Disorder (ASD) have difficulties with acquiring emotion regulation skills; and how is this related to their social impairments and comorbid psychopathology?

On 13 December 2018, Stijn Voskamp defended her thesis 'Onderwijsovereenkomst'. The doctoral research was supervised by Prof. mr. A.G. Castermans.

Parenting and Child Development is an intensive programme. However, if you are a highly motivated student you can consider applying for the Leiden Leadership Programme.

Bioprinters that enable scientists to engineer complex tissues and organs. It sounds like science-fiction, but not for the scientists of the Alireza Mashaghi lab at the Leiden Academic Centre for Drug Research. The lab has recently been equipped with two state-of-the-art bioprinters: BioX and LumenX+.…

During the last weeks of 2018, Judi Mesman presented the 'Kennisagenda Jeugd' to various departments and ministries, where she was welcomed with open arms. As figurehead of the NWA 'Jeugd' route, Judi worked together with the 'Taskforce Jeugd' in recent years on the development of the 'Kennisagenda…

AI has huge societal and economic potential and is widely used. But it also brings challenges: how do we combine human values with AI, how do we make AI more transparent and understandable, and what can AI and human cognition learn from each other, for example about language learning?

If you study Pedagogical Sciences in Leiden, you will be involved in the development of young people and children and how parents, teachers and social workers can contribute to this optimally.

Repairing organs, tissues and cells to fight chronic diseases.

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

How do humans construct their self?

The single cell group (SCG) is part of the Metabolomics & Analytics Centre Our research is centered around developing innovating analytical methods tailored for small-volume, or single cell analysis to enable metabolomics-driven systems biology in personalized health strategies. We are always on…

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

Promotor: B. van de Water

The team consists of

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

How do we experience sensual wonder and enchantment and to what extent can (early) modern imagination-techniques be implemented to create an artwork and performance, which offer a sensory and novel experience.

The Laboratory for Human Osteoarchaeology specialises in the macroscopic and microscopic analysis of human remains. We use cutting edge scientific approaches to address archaeological, historical, and anthropological research questions. In addition to paleopathological, histological, and 3D scanning…

Key publications of the Cancer Drug Target Discovery group

In order to optimize treatment, it is necessary to closely monitor and manage the patient’s health status by means of ‘precision diagnostics, personalized prognosis and targeted therapy’. The specialisation combines the techniques and applications of these sensing (monitoring) and stimulation techniques.…

The research project addresses the question how complaints in the voluntary youth care system are dealt with on the municipal level and what role (municipal) Children’s Ombudspersons play in this context, through qualitative research methods.

-

Are you in 4 vwo and interested in joining the Pre-University College? Read more about the steps you need to take for your application.

‘Visibility and secrecy are both valuable tactics and should not be antagonized in LGBT movements, ’ says Jingshu Zhu. Zhu defended her dissertation on Wednesday 21 February.

This publication examines the issues regarding the cross-border resolution of financial institutions, focusing on the power allocation between the home and host resolution authorities, i.e. the jurisdiction rule.

Resilient future generations that will shape a healthy society.

The master's specialisation Child and Adolescent Psychology consists of three main parts: the mandatory and elective courses, a thesis and an internship.

Participation in a PRE-Class costs €35 or €75 per pupil. In addition, participants may be asked for an additional contribution for excursions, for example. If so, this will be stated in the programme booklet. Travel costs to and from Leiden are at your own expense.

How do we decide on the long-term future of children placed in care in a valid, reliable, traceable and transparent way – together with parents and young people?

For this project we delve into children's digital media use during the transition from kindergarten to group 3 and investigate its impact on their social development.