NL-BioImaging AM is a distributed research infrastructure aimed at promoting progress in the most cutting edge microscopy technologies and providing open access to these technologies to a broad community of academic and industrial users. All Netherlands bio(medical) microscopy centers participate.

Promotor: H.J.M. de Groot

Wouter Eekhout, our data magician, came in 3d place in the ‪#‎LinksSDGs‬ - Natural language processing and data visualization challenge.

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

The study of orchid flowers, fruits, and inflorescences is crucial due to the remarkable diversity of orchid species and their unique adaptations to pollinators and seed dispersers. However, our understanding of the evolution and development of these organs within the orchid family remains limited.

Promotor: T. Schmidt

In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.

Promotores: G.W. Canters, T.J. Aartsma

This paper describes two synthetic lipid models designed to replace human stratum corneum (SC) in studies of the impact of volatile organic chemicals on the molecular organization of the skin barrier lipids.

With tomography it is possible to reconstruct the interior of an object without destroying.

A common method to solve expensive function evaluation problem is using Bayesian Global Optimization, instead of Evolutionary Algorithms.

This thesis describes the design, characterization and application of dextran based crosslinked network.

Radiography is an important technique to inspect objects, with applications in airports and hospitals. X-ray imaging is also essential in industry, for instance in food safety checks for the presence of foreign objects.

The central question of this thesis is: What drives late Middle Paleolithic stone artifact variability? In its attempt to answer this question, this thesis is a contribution to understanding variability within and between late Middle Paleolithic assemblages of the European Plain.

The AT-Hook Nuclear Localized 15 (AHL15) gene belongs to a plant-specific gene family of DNA-binding proteins. Overexpression of AHL15 in Arabidopsis thaliana delays developmental phase transitions whereas its loss of function causes a slight acceleration.

Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel

Analecta Praehistorica Leidensia 51

At ACPA, the collaboration between Leiden University and the University of the Arts The Hague, artistry and academia meet at the highest level.

‘Regenerative medicine’ explores ways to repair or replace damaged cells, tissues and organs with cell, stem-cell or gene therapy. It can lead to valuable breakthroughs in the treatment of chronic diseases such as diabetes, heart problems and kidney diseases or muscle diseases.

In this work, we investigate the minute circular dichroism effects of single nanoparticles.To this aim, we apply photothermal imaging with a polarization-modulated heating beam.

The Computer Systems, Imagery & media (CSI) research programme performs research on methods and techniques for the design, implementation and application of advanced computer systems, in particular parallel, distributed and embedded computer systems.

Promotor: Prof.dr. E. F. van Dishoeck, Co-promotor: A. N. Heays

Material Culture Studies revolves around the analysis of the cultural biographies of all sorts of material objects from flint axes, to pottery, to houses and monumental structures.

Lecture, Tuesday Talk

To overcome the limitations of slow and error-prone quality control, this research develops an advanced 3D imaging method for the rapid and reliable detection of internal defects in critical sectors.

How do people develop and how do they learn? How does their environment affect them? How do we ensure that they develop in optimal fashion? And what can we do if problems occur? These are questions that the researchers at the Institute of Education and Child Studies try to answer.

At the Leiden Curious Minds Centre, our research focuses on the relationship of exploratory behaviour and discovery learning to curiosity and the way children regulate their behaviour and emotions. We want to improve our understanding of how children can and do become more and more the captain of their…

This longitudinal study is focused on neurodevelopmental problems in young children with XXY, XXX and XYY, aged 1 to 6 years.

Erik Danen is looking at how to inhibit tumours that do not respond well to medicine – and he is making some headway. The Professor of Cancer Drug Target Discovery studies the interaction between tumour cells and their surroundings. Inaugural lecture on Friday 10 May.

On 13 December 2018, Stijn Voskamp defended her thesis 'Onderwijsovereenkomst'. The doctoral research was supervised by Prof. mr. A.G. Castermans.

In the Netherlands, levying tax on inheritances at death has been a fact of life for centuries. The presumed double taxation and its sad precursor are elements of the discussion about the levy of this inheritance tax, but so too are the possibilities to reduce the tax through ingenious legal constru…

In 2008, the intervention ‘Denken + Doen = Durven’ (Think + Do = Dare) was developed in the Netherlands (Bögels, 2008). This is a cognitive behavioral therapy program for children and young people between the age of 8 to 18, diagnosed with an anxiety disorder. The intervention is given by a professional,…

Developmental considerations in the design and delivery of cognitive-behavioural therapy for adolescent school refusal

Biological and behavioural measurements of parent-child interactions.

Across cultures, parents help their children master the social and linguistic codes needed in adult life. Recent research on language socialization found important cross-cultural differences, pointing out the need for more diversity for a full understanding of this process.

Why do children with an Autism Spectrum Disorder (ASD) have difficulties with acquiring emotion regulation skills; and how is this related to their social impairments and comorbid psychopathology?

Parenting and Child Development is an intensive programme. However, if you are a highly motivated student you can consider applying for the Leiden Leadership Programme.

The Young Academy Leiden (YAL) organises listening sessions across faculties. The aim of these listening sessions is to learn more about the wants and needs of (post-PhD) Early Career Researchers at Leiden University.

During the last weeks of 2018, Judi Mesman presented the 'Kennisagenda Jeugd' to various departments and ministries, where she was welcomed with open arms. As figurehead of the NWA 'Jeugd' route, Judi worked together with the 'Taskforce Jeugd' in recent years on the development of the 'Kennisagenda…

Bioprinters that enable scientists to engineer complex tissues and organs. It sounds like science-fiction, but not for the scientists of the Alireza Mashaghi lab at the Leiden Academic Centre for Drug Research. The lab has recently been equipped with two state-of-the-art bioprinters: BioX and LumenX+.…

PhD defence

AI has huge societal and economic potential and is widely used. But it also brings challenges: how do we combine human values with AI, how do we make AI more transparent and understandable, and what can AI and human cognition learn from each other, for example about language learning?

If you study Pedagogical Sciences in Leiden, you will be involved in the development of young people and children and how parents, teachers and social workers can contribute to this optimally.

The Laboratory for Human Osteoarchaeology specialises in the macroscopic and microscopic analysis of human remains. We use cutting edge scientific approaches to address archaeological, historical, and anthropological research questions. In addition to paleopathological, histological, and 3D scanning…

Promotor: B. van de Water

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

Key publications of the Cancer Drug Target Discovery group

In order to optimize treatment, it is necessary to closely monitor and manage the patient’s health status by means of ‘precision diagnostics, personalized prognosis and targeted therapy’. The specialisation combines the techniques and applications of these sensing (monitoring) and stimulation techniques.…