Plants, algae and cyanobacteria have the amazing capacity to perform delicate photophysical and photochemical processes of light capture, excitation transfer, charge separation and catalysis in fluctuating living environments. As a consequence, photosynthetic proteins and membranes form dynamic architectures.…

Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…

The goal of hit and lead optimization is to optimize suitable chemical starting points that can modulate a drug target. The methods and technologies used are similar to those in Hit Discovery, but once the compound has shown activity in an animal model, it moves from 'hit' to 'lead.'

Meet the scientists within the LED3 community

This thesis focuses on the study of transient and variable radio sources in the universe.

Joachim Koops, Professor of Security Studies and Scientific Director of Leiden University’s Institute of Security and Global Affairs (ISGA) has been awarded a ‘Jean Monnet Chair’ with a focus on ‘The European Union’s Role in Security and Global Affairs’ (EURISGA).

At the division of Biopharmaceutics, we aim to develop and test new therapeutic approaches to limit or even prevent the development of atherosclerosis in order to reduce the number of acute cardiovascular syndromes such as myocardial infarction or stroke.

Many metalloenzymes that are key to bioenergetics are membrane enzymes, with canonical examples the complexes I, II, III and IV in the mitochondrial inner membrane. To study these enzymes in a native-like lipid membrane environment, we aim to develop novel bioelectrochemical techniques.

On 1 September, the conference of the Kirchheiner Chair ‘Government and citizens: A matter of trust’ took place. In a packed hall in the beautiful Old Observatory of Leiden University, under the inspiring leadership of Willemien den Ouden, a debate was held on the role of the Dutch National Ombudsman,…

The Academic Language Centre interpreting and translation service has extensive experience in translating to and from Dutch and English. Our services are characterised by professionalism, quality, and reliability.

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

We study the physics of a broad range of biological and soft materials

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Promotor: Prof.dr. J. Kuiper

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.

Promotoren: G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Both psoriasis and atheroslcerosis are diseases characterized by a chronic and systemic inflammatory profile with local lipid disturbances that alter the barrier function of the skin (psoriasis) and cause the development of atherosclerotic plaques (atherosclerosis).

What are the functions of the endocannabinoid system?

The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: Dr. A. El Ghalbzouri

This thesis describes the design, characterization and application of dextran based crosslinked network.

Cardiovascular disease is the leading cause of death worldwide.

Human skin equivalents (HSEs) can be a valuable tool to study aspects of human skin, including the skin barrier, or to perform chemical or toxicological screenings.

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax

Cardiovascular syndromes are the major cause of death in Western societies.

The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…

The Supramolecular & Biomaterials Chemistry group comprises the PIs Alexander Kros, Roxanne Kieltyka and Gregory Schneider, and is active in the field of self-assembly of amphiphilic peptides and applying them in supramolecular chemistry.

Professor Barend Mons has been appointed Chair of the Commission High Level Expert Group

Cathalijne van der Plas will become Professor of Private International Law (0.4 fte) at Leiden University as of 1 October 2021. She succeeds Prof. Sierd Schaafsma who has become a judge at the Supreme Court as of 1 May 2021.

This was the programme for The Knowledge Orchard 2025:

Prof. Dr. Joost N. Kok is panel chair in the research assessment of Tampere University of Technology (TUT), Tampere, Finland.

Perec’s Lieux project consists of texts describing the author's places of memory, photographs, personal documents and ephemera collected in the street.

The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine. The available expertise extends…

In Voices on Birchbark Jos Schaeken explores the major role that writing on birchbark – an ephemeral, even ‘throw-away’ form of correspondence and administration – played in the vibrant medieval merchant city of Novgorod and other cities in the Russian Northwest.

Promotor: M.A.G.J. Orrit

The English Language and Culture study programme is also offered on a part-time basis.

Here you can sign up to our Babylab research. Each of our study investigates babies at a specific age or age range. We will contact you with details of these studies when your baby reaches the specific age. Importantly, you can always decide yourself whether you want to participate in a study or not…

Research in the Lemay Lab concentrates on Iontronics: the physics of mixed electronic-ionic charge transport.

Leiden Law School is pleased to announce that Professor Ursula Kilkelly, School of Law, University College Cork, Ireland, will visit Leiden in academic year 2022/2023 as Rotating Honorary Chair ‘Enforcement of Children’s Rights’.

As of 1 July 2019, Bart Custers is appointed as Professor of Law and Data Science at Leiden University. The chair is established at eLaw, the center for Law and Digital Technologies at the Faculty of Law. Bart Custers will focus on the intersection of law and digital technologies, on the one hand on…

On 14 February, the second student edition of Mediaforum, journal of media and communication law, was festively launched with a symposium in the Academy Building of Leiden University. During the symposium, the student authors, some of them from our own ranks (Roosmarijn Altink, Roosmarijn Niesing and…

Assistant professor Max van Duijn is the new chair of The Young Academy. He aims to support young academics, bring research closer to society and make academia more resilient.

PhD defence

Rutger Leukfeldt has been appointed endowed Professor of Governing Cybercrime at the faculties of Governance and Global Affairs (FGGA) and Leiden Law School. Leukfeldt: 'It’s great that the two faculties are joining forces at a time when we’re faced with enormous challenges in the field of cybercrim…

The Aging and Immunity group is led by Dr. Amanda Foks. In this group we aim to investigate how aged immune cells contribute to atherosclerosis and identify novel therapeutic targets and strategies to extend health span and inhibit cardiovascular disease.