How did we come into existence? Are we alone? These questions have driven humans for centuries.

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Research in the arts at the Academy of Creative and Performing Arts (ACPA)  

The Institute of Criminal Law and Criminology conducts extensive research on imprisonment. Sending a person to prison is the most severe form of punishment that can be applied in the criminal justice systems of European countries. In most countries, the number of prisoners has risen in recent decades.…

In the field of Western art music, improvisation has become a much discussed topic. In this interdisciplinary study I argue that in this context, improvisation is not to be seen as a quasi-autonomous skill or art form, but as an aspect of music-making in general.

On the 17th of June Rea Matsangou successfully defended a doctoral thesis and graduated.

On 21 September 2022 Arfiansyah successfully defended a doctoral thesis and graduated.

Stella Morgana defended her thesis on 31 March 2021

This is a research project on the implementation of national mathematics curriculum reform in Chinese junior high school. The research is expected to provide insight into the ways and reasons of mathematics teachers in Chinese junior high school for implementing national curriculum reform.

On the28th of September Didi van Trijp successfully defended a doctoral thesis and graduated.

Research has shown that the impact of feedback can be very powerful on second language acquisition. However, how to provide adaptive feedback on speaking skills in foreign languages and how to provide differentiated support in secondary schools in regular secondary schools classes of often 25-30 students?…

On 1 September 2022 Afke van Ewijk successfully defended a doctoral thesis and graduated.

In this research I assess the impact of the recently discovered gas reserves south off Cyprus on the escalation of the Cyprus conflict.

PhD candidates carry out a programme of independent research and additional (limited) course work, culminating in production of a PhD thesis in typically 4 years.

This dissertation and the corresponding films and recordings presented here are an effort to distil an approach to performing the orchestral music of Johannes Brahms that is significantly different from what has hitherto been produced in the fields of both Mainstream Orchestral Performance Practice…

One-size-fits-all digital gamification sometimes hinders students’ learning due to the ignorance of individual differences. This project aims to explore how tailored digital gamification can be used in higher education and its effects on university students’ motivation and learning outcomes.

On the 31 March 2022 Mr. Taufiq Hanafi successfully defended a doctoral thesis and graduated.

On the 26th of May Pao-Yi Yang successfully defended a doctoral thesis and graduated.

On the 2nd of September Jiyan Qiao successfully defended a doctoral thesis and graduated.

This dissertation presents a new perspective on the life, work and character of the Dutch physical chemist Jacobus Henricus van ’t Hoff, first recipient of the Nobel Prize in Chemistry, and one of the most important and colourful scientists in Dutch history. The image of Van ’t Hoff that emerges from…

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This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.

In this dissertation, we study partition-based models that can be used both for interpretable predictive modeling and for understanding data via interpretable patterns.

This Thesis describes the synthesis of D-alanylated ribitol-based wall teichoic acids from S. aureus to probe their interaction with immune-binding partners.

An understanding of our past helps students grasp the complexities of our world today and how our current biology and social structures came to be. By leveraging student interest into what makes us human, we help guide them to engage with topics ranging from archaeology to climate change, medicine,…

The findings in this thesis improve the understanding of 1) the relationship between exposure characteristics and toxicity of ENPs, 2) the joint toxic action of ENP mixtures and the comparison to metal salt mixtures, 3) how NOM affects the individual and joint toxicity of ENPs, 4) the extent of trophic…

The aim of this thesis was to develop aluminium salt-based nanoparticles that may ultimately be used as adjuvant in human vaccines.

In this thesis we push the boundaries of high-resolution imaging at radio frequencies between 100 and 200 MHz. Using the International LOFAR Telescope that spans across Europe we achieve sub-arcsecond angular resolution.

The aim of this thesis is to present novel techniques for proving cryptographic schemes secure against quantum adversaries. Most results are within the context of an idealized model called the ‘quantum random-oracle model’.

Optical cavities are useful tools to enhance the interaction between light and matter, which is important to make good quantum emitters. However, it turns out that the cavities themselves (without any quantum emitters) are already interesting objects to study.

When after four years or more, you have finished your dissertation, it is time to prepare for the defence procedure.

Tuberculosis (TB) is associated with 1.5 million deaths annually. There is a need exists to optimize both current as well as novel antibiotic combination treatment strategies to improve the effectiveness and safety of treatments against TB.

This thesis focuses on the development of sample-preparation methods for small amounts of samples and applying the developed methods to muscle tissues to investigate the mechanisms involved in sarcopenia.

This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.

Viral diseases constitute one of the major challenges in modern medicine. Membrane-targeting have broad-spectrum potential and could distinguish viral membranes from the host cell plasma membrane by the difference in membrane curvature.

The thesis introduces three methods for high-dimensional prediction problems in the biomedical field. The methods make use of empirical and variational Bayes in the estimation.

In this thesis, we examine various systems through the lens of several numerical methods.

Within this thesis the central stage is taken by the discovery and investigation of transglycosylation of sterols. First, investigation focuses on the development of a method to accurately detect and quantify glucosylated metabolites in biological materials.

To improve treatment of breast cancer patients it is important to understand all stages of breast cancer from initiation to in situ disease and progression to invasive disease. In this thesis we use intraductal injections of patient derived tissue to model ductal carcinoma in situ and invasive breast…

The adsorption of D2 and CO2 on catalyst surfaces is studied using a molecular beam in ultra-high vacuum.

In this thesis I examine how soil biotic and abiotic characteristics change and interact throughout the course of afforestation and how they subsequently impact tree performance.

The work described in this thesis focuses on the development of linear or cyclized peptide probes against protein N-methyltransferases to characterize their specific binding behavior, providing further binding details for inhibitory activity study.

This thesis describes research aimed at discovering inhibitors selective for either of the two endoplasmic reticulum α-glucosidases, ER-I and ER-II, with the overarching goal of discovering new antiviral agents to treat viruses that rely on host N-glycosylation for proliferation.

Demonstration experiments are a potentially powerful instrument to improve the micro-macro thinking of students in secondary education. Therefore we want to design a practical and generative approach to assist teachers to develop lessons with a demonstration experiment.

The Animal Welfare Body Leiden (AWB) is an internal entity responsible for the well-being of all laboratory animals at Leiden University and the Leiden University Medical Center. It is actively involved in all aspects of research involving animals. The AWB has several legal responsibilities, including…

What is effective viewing behavior for foreign language learners and how can teachers effectively train language learners to apply effective viewing strategies that will maximize their learning when viewing subtitled materials?