For more information regarding ongoing research projects, please contact Prof. Johan Kuiper.

This thesis examines silicon pore optics (SPO), a technology that exploits silicon wafers from the semiconductor industry to create extremely high quality X-ray optics, by studying its manufacturing process, applications, and prospects.

Registration for the Co-Align 2023 conference is open!

Students stream into the lecture hall, handing in their mobile phones at the door. Once everyone’s seated, silence descends and all eyes turn to the large screen at the front of the lecture hall. A live connection has been set up with the prison where Marco is a long-term inmate. Today, the students…

Elk jaar organiseert het LIBC in samenwerking met de gemeente Leiden een Publieksdag over hersenonderzoek.

This thesis aims to develop model-based approaches to optimize drug dosing in patients with overweight and (morbid) obesity.

Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…

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Leiden biophysicist Stefano Coppola has received the prestigious AXA Research Fund postdoctoral fellowship. With this grant he can work for two years on a project to research the role of mechanical factors in the development of pancreatic cancer.

Professor Tom Huizinga (LUMC) specialises in rheumatoid arthritis. He joined forces with alumni and the Natuurwetenschappelijk Gezelschap Leiden, a society that aims to share knowledge of the natural sciences and medicine, to explore the symptoms of the disease. With this form of arthritis the fluid…

Ten Leiden students have received a prize from the Royal Holland Society of Sciences and Humanities (KHMW). They were nominated by their degree programme. Who are these students?

Announcement of a new publication by Janneke Verheijen, lecturer at the Institute of Cultural Anthropology and Development Sociology.

Physics and Engineering Approaches to Biomedicine and Pharmacology

Professor of Cardiothoracic Surgery, in particular pulmonary surgery, Jerry Braun will give his inaugural lecture on Friday 23 September entitled ‘Out of countless millions’. Braun has been a professor and acting head of the LUMC’s Department of Cardiothoracic Surgery since January 2020. Covid meant…

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The aim of this thesis was to study phage infection in Streptomyces, focused on cell wall-deficient cells. Bacteriophages (or phages in short) attach to the cell wall of bacteria after which they replicate and lyse the host cell.

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Projects within the theme ‘Computational Biology’ aim to employ mathematical or computational dynamical modelling approaches to discover novel concepts that are important for drug development.

Promotor: M.A.G.J. Orrit

Speech Prosody is the biennial meeting of the Speech Prosody Special Interest Group (SProSIG) of the International Speech Communication Association (ISCA).

SBB research focuses on the complex operational, organisational dynamics of technology-intensive sectors.

The research of the Biotherapeutic Delivery group led by Joachim Van Guyse focuses on developing novel polymer-based formulations for therapeutic nucleic acid and protein delivery. The research revolves around developing structure-activity relationships between the chemical structure of polymers, the…

MHC class I and MHC class II molecules present peptides to the immune system to drive proper T cell responses. Pharmacological modulation of T-cell responses can offer treatment options for a range of immune-related diseases.

This thesis explores squaramide-based supramolecular polymers and hydrogels, enhancing their mechanical strength for 3D cell culture.

Explore how skateboarding functions as a prefigurative learning tool in 'Skate/worlds.' This volume examines skateboarding's therapeutic potential, its role in queering and decolonizing education, and its impact on parenting and care work through perspectives from writers, educators, and activists.

Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…

In autoimmune diseases such as rheumatism and diabetes the immune system attacks autologous proteins. Leiden researchers are trying to discover how this comes about.

Lifelong learning | “Even though we were spread across five continents, there was a strong sense of connection.”

University lecturer Andrew Gawthorpe comments in the Sydney Morning Herald on the possibility the USA have fewer munitions available for other conflict zones, such as Ukraine.

The Division of BioTherapeutics at the Leiden Academic Centre for Drug Research (LACDR) is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.

Methods of treatment for chronic illnesses are limited. Doctors and researchers at Leiden University Medical Center (LUMC) and Leiden University are working on new therapies as an alternative for organ transplants. The goal is to cure the illnesses by restoring organs to their original function. Stem…

Opponents of drastic nitrogen measures argue that the nitrogen calculation model is not reliable enough. Nitrogen professor Jan Willem Erisman: 'It is now much more important to discuss the choices we make on the basis of the outcome. The differences are much bigger than the uncertainties in the mod…

What are the host immune defence mechanisms that control intracellular infections and how are these subverted by pathogens?

Can we improve the treatment of post-traumatic stress disorder (PTSD)? Our young and promising psychologist Rianne de Kleine receives a Veni grant to carry out her research on the treatment of post-traumatic stress.

LUMC researchers are looking for factors that point to illness at an early stage.

In 2020, Leiden University launched its stimulated interdisciplinary programs, including one focused on regenerative medicine.

Can the conditioning paradigm be used for checkpoint inhibition cancer treatment?

The research team

The Leiden University Medical Center (LUMC) is committed to improving healthcare and the health of individuals. The LUMC staff put this mission into practice on a daily basis with their leading research, cutting-edge teaching and optimal, innovative healthcare.