Have you ever wondered how you can increase the visibility, accessibility, and recognition of your research while complying with funding and national requirements? LUCRIS is the answer!

While bioinformatics methods deal with the analysis of sequence information (be it proteins or DNA), the field of cheminformatics is concerned with the analysis of small-molecule datasets.

Explore the information activities for the MSc Democracy and Representation at Leiden University, including online open days, Q&A sessions and virtual campus tours.

Do you want to know more about the master's specialisation Education and Child Studies and what it's like to study in Leiden?

Get to know us through our online and in-person events for prospective students!

Get to know us through our online and in-person events for prospective students!

Get to know us through our online and in-person events for prospective students!

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Promotor: W. Jaffe, Co-promotor: K. Meisenheimer

Heightened activation of the striatum that adolescents show in response to reward is often associated with risk-taking and negative health consequences. This article in Nature Communications investigates a potential positive side of this heightened activation. It shows that the activity peak in late…

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

This article introduces the special issue on ‘Digital Activism’ by exploring some of the trends in social media activism and scholarship thereof. The authors ask to what extent this literature helps us understand Asian forms of online activism, which forms of activism have relatively done well, and…

Promoting sustained physical activity through tailored incentive-based interventions for diverse cardiovascular disease patient groups.

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

The key characteristic of active matter is the motion of an emergent collection (such as a flock of birds), which is driven by the consumption of energy by its active components (i.e. individual birds).

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea

The blended flipped classroom is a partially online, partially offline course to teach social science research methods. Online, students watch video lectures, do readings, and complete short exercises to acquire basic knowledge of research methodologies and academic skills.

Activity-based protein profiling (ABPP, also termed chemical proteomics), is one of the pillars of chemical biology, and at LED3 we have taken it to the next level. ABPP allows the assessment of protein function in live cells and tissues, which means that the activity of a complete protein family can…

The close interaction between organic chemi stry and biology goes back to the late 18th century, when the modern natural sciences began to take shape. After synthetic organic chemistry arose as a discipline, organic chemists almost immediately began to pursue the synthesis of naturally occurring compounds,…

Deficiency of glucocerebrosidase (GBA) underlies Gaucher disease, a common lysosomal storage disorder. Carriership for Gaucher disease has recently been identified as major risk for parkinsonism. Presently, no method exists to visualize active GBA molecules in situ. We here report the design, synthesis…

This book examines how renewed forms of artistic activism were developed in the wake of the neoliberal repression since the 1980s.

Find out about information activities for the MSc in Nationalism, Ethnic Conflict and Development at Leiden University, including webinars, online open days, virtual tours and Master Talks videos.

Discover the information activities for the MSc Political Theory: Legitimacy and Justice at Leiden University, including webinars, virtual open days, Q&A sessions and events for prospective students.

Learn about information events and activities for the MSc The Politics of Artificial Intelligence at Leiden University, including webinars, virtual sessions, and application Q&A.

Promotores: Prof. Dr. Th.J.C. van Berkel, Prof. Dr. M. van Eck

The goal of the research presented in this thesis was to explore the chemical space of ruthenium(II) photocages, investigate their ability to host potent chemotherapy drugs, and to red shift the activation wavelength of the most promising PACT candidates to conduct biological studies.

Discover the HAS master at Leiden University – LUMC. Join the Experience Day and student for a day with a mini lecture, case study, and meet students and alumni.

This thesis provides an overview of the development of the Pair Configuration to Molecular Activity Coefficient (PAC-MAC) model.

Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.

Discover the HAS master at Leiden University – LUMC. Join the Experience Day and student for a day with a mini lecture, case study, and meet students and alumni.

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.

This article on private active cyber defense by Dennis Broeders is part of a special issue of the Journal of Cybersecurity, based on a selection of contributions taken from the 2019 Conference on Cyber Norms organized by The Hague Program for Cyber Norms.

The research question is that unconscious perseverative cognition (UPC) is responsible for a considerable part of cardiovascular (CV) activity that occurs even in the absence of threats and other stressors that one may encounter in one’s daily life.

Climate change is one of the largest challenges faced by humanity. To combat this research into alternatives to fossil fuels is ongoing. Dihydrogen is considered a good alternative fuel, since its burning only forms water.

A key challenge in neuroscience is understanding how neurons in hundreds of interconnected brain regions integrate sensory inputs with previous expectations to initiate movements and make decisions.

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

How was anti-communism organized in the West? New volume edited by Giles Scott-Smith, Luc van Dongen and Stephanie Roulin on the aims, arguments and associations of a range of transnational anti-communist activists during the Cold War.

Promotor: E. Bouwman, Co-promotor: S. Bonnet

In this article in International Affairs, Saskia Postema and Jan Melissen examine Chinese celebrities' UN-affiliated Weibo activism in the context of China's increasing engagement in the United Nations, which coincides with a shrinking domestic public sphere under Xi Jinping's leadership.

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

This thesis describes research aimed at discovering inhibitors selective for either of the two endoplasmic reticulum α-glucosidases, ER-I and ER-II, with the overarching goal of discovering new antiviral agents to treat viruses that rely on host N-glycosylation for proliferation.