461 search results for “induced pluripotent stem cell” in the Staff website
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A unique defence: Bacteria lose cell wall in the presence of virus
Bacteria temporarily live without their cell wall if dangerous viruses are near. A remarkable feature, as the cell wall is a sturdy barrier against threats. Still, the discovery has a logical explanation ánd might be of a consequence for fighting pathogenic bacteria, according to Véronique Ongenae,…
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How cells determine the fate of proteins (and can we do it too?)
Cells in our bodies are often threatened by errors in our own proteins. The FLOW consortium, comprising scientists from various institutions including Leiden, is poised to meticulously map out for the first time how cells control proteins, correcting or removing faulty ones. This endeavour holds promise…
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From nanoscale to whole organism: at the Cell Observatory, researchers study life in detail
About forty microscopes, various laboratories, and some 15,000 zebrafish: that’s Sylvia le Dévédec's workplace. She is one of the managers of the Leiden Cell Observatory, a unique facility accessible to all researchers.
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collagen to canvas: interactive artwork brings the world between our cells to life
What’s really happening in the space between the cells in your body? With the Collagen Canvas project, students from Leiden University invite you to explore this question by blending science with art. This interactive artwork immerses you in the dynamics of the extracellular matrix—the invisible structure…
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Caught in living cells: how bacteria regulate their genes to defend themselves
For the first time, it was shown in living cells how the bacterium E. coli regulates genes that help it survive in a new environment. Biochemist Fatema Zahra Rashid managed to do this using a technique she fine-tuned. Her research into changes in 3-dimensional chromosome structure offers clues for ways…
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EIC Pathfinder Challenge grant for research into autoreactive B cells in cardiovascular disease
At the division of BioTherapeutics, Amanda Foks, Bram Slütter and Ilze Bot have obtained a €4 million research grant from the HORIZON 2022 EIC Pathfinder Challenge “Cardiogenomics”, entitled “B-specific: B-cell related gene and protein markers with prognostic and therapeutic value for CVD”.
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Olivier Béquignono.j.m.bequignon@lacdr.leidenuniv.nl | 071 5272727
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How to hijack natural destruction in cells: ‘We need to understand it through and through’
Destroying proteins from the Golgi apparatus of the cell in a controlled manner. That is the focus of chemist Marta Artola’s pioneering research. By developing a groundbreaking technology to target specific proteins in the Golgi, Artola aims to unlock new ways for drug development. For this ambitious…
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Saloni Saxenas.saxena@biology.leidenuniv.nl | 071 5274950
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Physics in the picture: cancer cells as an explosion of fireworks
When you think of physics, do you think only of complicated formulas? You’re not the only one. Therefore, every year, the Leiden Insitute of Physics organises the LION Image Award to show another side of physics: beautiful images about intriguing science. The winner of the 2022 photo competition captured…
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Leiden chemists discover new ways in which single-celled organisms organise their DNA
It has only recently been discovered that single-celled organisms (bacteria and archaea) also have histones—proteins that structure DNA. Now, Leiden PhD candidate Samuel Schwab has found that the histones in these organisms are much more diverse than previously thought. Schwab and his colleagues describe…
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technique uncovers disease-related changes in tiny droplets within our cells
Understanding the behaviour of tiny droplets in our cells could aid the search for new treatments. A team of Leiden researchers has developed a groundbreaking method to study how these droplets transition from liquid to solid. This change plays a role in various diseases, including neurodegenerative…
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BPS-student Ramazan Kiliç receives Travel Grant for Research Symposium in Baltimore, USA
This summer, one of our BPS-master students, Ramazan Kiliç, will travel to Baltimore to present his research at the annual ARRE Research Symposium, a conference on ASXL-disorders that attracts researchers from all over the world, including the US, Japan, Germany, Ireland and, of course, The Netherlands.…
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Proof of Concept grants for four Leiden researchers
Four Leiden researchers have been awarded Proof of Concept grants by the ERC. These grants, each worth 150,000 euros, help researchers translate the findings of previous ERC projects into innovative practical applications.
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Mathematical models for mechanically induced morphogenetic pattern formation
PhD defence
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Templeton Grant Drukker News
In a project funded by the John Templeton Foundation to the group of Micha Drukker, scientists will produce stem cells from short and long living understudied species to model cellular and organismal lifespan.
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Joost Willemsejwillemse@biology.leidenuniv.nl | 071 5274986
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Nature Communications paper on therapeutic melanoma inhibition by local micelle-mediated cyclic nucleotide repression
Cancer immunotherapy represents a significant breakthrough in cancer treatment. However, tumors have numerous mechanisms by which they evade destruction by the immune system. It is therefore necessary to decipher and reverse these mechanisms in order to improve immunotherapies.
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Microstructural and Metabolic Alterations in the Zebrafish Brain Induced by Toll-Like Receptor 2 Deficiency
PhD defence
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Stress-induced protein dynamics and growth arrest in C. elegans during development
PhD defence
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Lost in translation: The toll-like receptor 7 induced pharmacological challenge model of the skin
PhD defence
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Marie Depuydt receives presentation award at the 10th EMBRN meeting in Utrecht
From 11-13 July 2022, the 10th EMBRN International Mast Cell and Basophil Meeting took place in the Utrecht University Academia Building in Utrecht. During this meeting, novel insights and developments in the field of mast cell and basophil biology in both health and disease were shared.
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Leideners and researchers learn from each other at the Science Market
3 October University has become something of a tradition: a bit of science among the Leidens Ontzet celebrations. During the new and improved edition, the WetenschapsWarenMarkt (Science Market), visitors spoke to researchers about the nitrogen problem, making organs and the city’s connections with A…
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Four Leiden consortia awarded large NWO grants
No less than four Leiden research teams have been awarded a grant by NWO. On 27 July NWO honoured 21 applications in the Open Competition ENW-XL. NWO awards the grants to consortia in the exact and natural sciences who are doing unconnected fundamental research that is 'driven by curiosity'.
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Alireza Mashaghi Tabaria.mashaghi.tabari@lacdr.leidenuniv.nl | 071 5274425
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Remko Offringar.offringa@biology.leidenuniv.nl | 071 5275097
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FAIR imaging for advancing science
Lecture, Tuesday Talk
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The aging B cell landscape in atherosclerosis
PhD defence
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revealed: Lighting up dark exomoons Observational signatures of tidally induced volcanism in other worlds
PhD defence
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Malformations in heart, eyes and nervous system: Nano-plastics disrupt growth
Nano-plastics cause malformations. Meiru Wang, researcher at the Institute of Biology Leiden, looked at the extreme effects polystyrene nano-particles could have, using chicken embryos as a model. Her results were quite alarming. Especially as nano-particles are everywhere. In the air, floating through…
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Leiden University honours Lex van der Eb with University Medal
Leiden University has awarded its prestigious University Medal to Emeritus Professor Lex van der Eb. As a pioneer in genetics and molecular biology, he received this honour for his services to science and his key role in the development of the Leiden Bio Science Park (LBSP).
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Harry StroomerFaculty of Humanities
h.j.stroomer@hum.leidenuniv.nl | 071 5272727
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ULLA workshop 2023 Leiden
This week, we are hosting the ULLA workshop 2023. We are proud partner of the ULLA. It is the European University Consortium for Pharmaceutical Sciences in which LACDR participates for already 30 years.
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Two young researchers win Krijn Rietveld Award for innovative research on blood donation and colorectal cancer
One used 3D cell models to study colorectal cancer, while the other used machine learning for more efficient blood donation. For these achievements, Marieke Vinkenoog and Simon Christian Hansmann were awarded the Krijn Rietveld Memorial Innovation Award on Tuesday 2 September.
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Combating gram-negative resistance: targeting the cell envelope
PhD defence
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Leiden scientists create first-ever dengue-on-a-chip to study this deadly virus
Researchers at Leiden University have created a unique model that mimics how disease develops after a dengue infection. This 'dengue-on-a-chip' model helps them study the virus more effectively. The timing is crucial, as climate change is causing dengue to spread worldwide.
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Macrophage cell models for the investigation of Gaucher disease
PhD defence
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CD8+ T-cells in atherosclerosis, recognizing their contribution
PhD defence
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Bioorthogonal tools to study fatty acid uptake in immune cells
PhD defence
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Myrtille Koerselmanm.e.koerselman@lacdr.leidenuniv.nl | 071 5276270
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Kostas Tassisk.tassis@lacdr.leidenuniv.nl | 071 5276302
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Leo Pricelsprice@lacdr.leidenuniv.nl | 071 5272727
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Matthijs Vlasveldm.p.vlasveld@lacdr.leidenuniv.nl | 071 5272727
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Nasi Liun.s.liu@lacdr.leidenuniv.nl | 071 5276225
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Martijn Moném.j.mone@lacdr.leidenuniv.nl | 071 5276105
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Vidi grant for seven researchers from Leiden University
From malaria parasites as a vaccine to how top-level bureaucrats reach their decisions: seven researchers from Leiden University have received a Vidi grant from the Dutch Research Council (NWO). This 800,000-euro grant will enable them to develop their own innovative line of research over the next five…
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Thirteen NWO Open Competition XS grants for Leiden researchers
From medicines from snake venom to supercrops and the origin of words. Thirteen researchers from Leiden University will receive Open Competition XS grants from the Dutch Research Council (NWO).
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Five tips for The Night of Discoveries
Discover budding creators, artists and researchers at the Night of Discoveries art and knowledge festival. And many researchers from Leiden University are taking part.
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Novel analytical approaches for the characterization of cell-based medicinal products and their formulation
PhD defence
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Remember or Die: action of thermomemory when proteostasis meets phase separation
PhD defence