Why are mycobacteria such successful pathogens? And are there defence mechanisms in the body that help reduce an infection? To find out, Annemarie Meijer has been awarded the NWO Open Competition ENW-XL grant. She will not explore this quest alone. Five other leading Dutch research groups are participating…

On March 24, 2025, World TB Day, we (Annemarie Meijer (IBL), Matthias Barz (LACDR), and Simone Joosten (LUMC) hosted the symposium „A Dutch Perspective on Mycobacterial Infections“, which brought together the Dutch scientific community working on mycobacterial infections.

Suruchi Nepal, postdoc in the group of Coen van Hasselt at LACDR, was awarded an NWO XS project which aims to study the response to antibiotic treatment during a urinary tract infection (UTI). This knowledge will be used to determine how treatments of UTIs with antibiotics can be further improved.

Optimised antibiotic combinations can combat bacteria more effectively while also slowing the development of resistance. Scientists from five European countries are joining forces to identify such combinations and provide tools for others to do the same. The project is led by Professor Coen van Hasselt…

Tuberculosis bacteria survive by hiding in our immune cells. In her PhD research, biologist Salomé Muñoz Sánchez explores how boosting the body’s own defenses might outsmart this deadly pathogen. Her work reveals two key proteins that help immune cells destroy the bacteria.

As part of the ZonMW Antibiotics resistance funding program, the LACDR cluster Systems Pharmacology was awarded €455.255 for a research project to develop novel clinical biomarkers for bacterial infections.

When a baby is born too soon, every minute counts – and so does every decision. To reduce uncertainty in those critical moments, biopharmaceutical scientist Manchu Umarani Thangavelu dedicated her PhD to identifying molecular markers of preterm birth and neonatal infection.

PhD defence

More than 1.3 million people worldwide die of tuberculosis (TB) each year, making research on its prevention and control essential. Researchers from various disciplines in Leiden are studying TB. A symposium on 24 March will highlight different activities in the hope of boosting nationwide collabora…

No less than four Leiden research teams have been awarded a grant by NWO. On 27 July NWO honoured 21 applications in the Open Competition ENW-XL. NWO awards the grants to consortia in the exact and natural sciences who are doing unconnected fundamental research that is 'driven by curiosity'.

PhD defence

Is it a coincidence that three chemists from the same department have each independently received a ZonMw grant? 'No,' the researchers agree in unison. 'The role of chemistry in medical biology is becoming increasingly important, and we’ve worked hard to make this happen.'

Biological agents are micro-organisms such as bacteria, parasites, moulds, viruses and their waste products. This category also includes genetically modified variants (GMOs). These agents may form a risk for your health, which is why we apply a number of legal and other guidelines to prevent people…

Human resources

A job thanks to COVID—something not many people can claim. But PhD candidate Vera Arntzen can. Over the past four years, she has mapped two crucial characteristics of SARS-CoV-2 infections. Thanks to her research, experts can now make well-informed decisions on matters like quarantine duration, which…

Regardless of whether you work at a desk or in a lab, all workplaces have their risks. As your employer, the University aims to create a healthy workplace and to limit possible health risks. Here you will find the main risks and measures that we take to reduce them.

Regardless of whether you work at a desk or in a lab, all workplaces have their risks. As your employer, the University aims to create a healthy workplace and to limit possible health risks. Here you will find the main risks and measures that we take to reduce them.

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Phage therapy is a novel yet unmatured therapeutic approach in the face of the crisis of antimicrobial resistance (AMR). Dr. Tingjie Guo received a grant from the Elise Mathilde Fund and the LUF to develop innovative phage-antibiotic combination treatment strategy for combating AMR.

Rob van Wijk (LACDR, Leiden University) and Robin van den Biggelaar (LUCID, LUMC) have been awarded a €10,000 euro KIEM grant from Leiden University to start an interdisciplinary collaboration to investigate the potential of AMPK activation as an adjunctive therapy to enhance tuberculosis treatment.

Bacteria temporarily live without their cell wall if dangerous viruses are near. A remarkable feature, as the cell wall is a sturdy barrier against threats. Still, the discovery has a logical explanation ánd might be of a consequence for fighting pathogenic bacteria, according to Véronique Ongenae,…

Leiden researcher Anne-Grete Märtson brought together a large number of studies to better understand antibiotic dosing in patients with obesity. The publication in a renowned medical journal has already garnered much positive reactions, Märtson says. ‘It’s high time researchers started sharing more…

Cryogenic memories, antibiotic treatment for urinary tract infections and recycling plastic sustainably. These are the subjects of the three NWO-XS grants awarded to Leiden Science researchers.

The antibiotic EVG7, developed in Leiden, has proven capable of fighting the dangerous gut bacterium C. difficile with only a minimal dose. What’s more, the bacterium is far less likely to return, a major issue with existing antibiotics. The research was published in Nature Communications.

Resistance to antibiotics is a major problem in health care. Thanks to a grant from the Elise Mathilde Fund and the LUF, pharmacologist dr. Coen van Hasselt can look for new dosing schedules to reduce the development of antibiotic resistance.

'What nature made isn’t necessarily an optimized medicine to use in the human body,’ says Professor of Biological Chemistry Nathaniel Martin. That’s why a group of Leiden researchers is making a chemistry-based improved version of the frequently used antibiotic vancomycin. They received an NWO NACTAR…

Infecting each other with viruses and bacteria while protecting yourself with medicines and vaccinations. Sounds like a fun evening, right? Master students Life Science & Technology Rafael Jezior and Dennis de Beeld certainly think so. Together, they developed ImmunoWars: an exciting card game based…

Effectively treating a severe case of pneumonia is often challenging. Identifying the pathogen behind it can be difficult. PhD candidate Ilona den Hartog tried something new: ‘We searched for answers in substances our own body produces.’ PhD defence on 17 September.

When a bacterium becomes more resistant to one antibiotic, it sometimes becomes more sensitive to another. To better understand this interaction, researchers from the Leiden Institute of Biology (IBL) and the Leiden Academic Center for Drug Research (LACDR) under supervision of Daniel Rozen and Coen…