The transcription factor MYC is a master regulator implicated in the majority of human cancers. Despite its central role, MYC has long been considered "undruggable" by small molecules, lacking binding pockets and featuring disordered regions. While larger biomolecules could potentially disrupt MYC function,…

Human cells are protecting their proteins from unfolding and aggregating. That's what biophysicist Alireza Mashaghi and his team discovered after seven years of in-depth research into the folding mechanisms of proteins. With an unprecedented approach, the team was able to study the folding of a single…

A breakthrough from the PhD research of medical chemist Elmer Maurits may help patients with autoimmune diseases and blood cancer in the future. But bringing a discovery from the lab to the clinic is not so easily done. Thanks to NWO's Venture Challenge, Maurits and his team will receive ten weeks of…

On Tuesday evening 22 August, our very dear colleague Jo Hermans passed away. Jo had been ill for some time, but continued to enjoy life in good spirits until the very end. He meant a great deal to Leiden University and will be remembered with fond memories by many.

A flu virus could cause a pandemic. And then we would be poorly armed because flu viruses are starting to become resistant to flu medications like Tamiflu. Chemist Merijn Vriends successfully worked on an improved version of such medications. He will be awarded his doctorate on September 12th.

One discovered that arteriosclerosis resembles an autoimmune disease, while the other developed a system to aid in the search for new medications. For these achievements, Marie Depuydt and Jurren de Groot were awarded the Krijn Rietveld Memorial Innovation Award on the evening of Tuesday 4 June.

3 October University has become something of a tradition: a bit of science among the Leidens Ontzet celebrations. During the new and improved edition, the WetenschapsWarenMarkt (Science Market), visitors spoke to researchers about the nitrogen problem, making organs and the city’s connections with A…

Smart drug carriers, uneven cosmic expansion, and solar energy storage in molecules. These are the topics of three newly awarded NWO-XS grants to researchers at the Faculty of Science.

As a bachelor student of Bio-Pharmaceutical Sciences, Femke Vlaswinkel wrote a research proposal she was allowed to carry out in her master’s BPS. Femke subsequently graduated with honors. Her research was published in the journal Scientific Reports, she won an award from the Dutch Pharmacy Society…

Tracking mucus-eating bacteria, mapping the complexity of planetary nebulae and a signalling pathway in cancer. These three Leiden projects have been awarded Open Competition Science-M funding by the Dutch Research Council.

The fact that scientists are increasingly better able to access molecular cell and tissue data also brings with it a new challenge: how can scientists find the information they need for research among the vast amount of data available?

Yeast, alpacas, and antibodies. They may seem unrelated, but within the project of the Leiden iGEM students, they come together perfectly. For the international synthetic biology competition iGEM, the team is working on an innovative method to produce nanobodies—a special form of antibodies—using brewer’s…

A team of LACDR scientists from three different divisions (SPP, BT, MC) contributed to a book on "Substance P in Health and Disease," which will be published by Elsevier. The project was a collaboration with Hannover Medical School (Germany) and was coordinated by Alireza Mashaghi. Master students Ehsan…

Eleven researchers from Leiden University have been awarded an Open Competition Domain Science ENW XS grant by the Dutch Research Council for their research projects. They are researching how to make software faster and greener, improve cancer detection and reduce anxiety by manipulating the biological…

An impressive 22 research projects by Leiden researchers have been awarded Veni funding from the Dutch Research Council (NWO).

Leiden researchers have found clues to why a rare pregnancy disorder is mild in some babies but life-threatening in others. Their discovery opens the door to a test that could identify severe cases during pregnancy. Fortunately, a treatment already exists.

People with relatively high levels of lipids in their blood are less likely to develop allergic conditions such as eczema and asthma. These lipids cause genes that play a key role in allergic reactions to be less active. Researchers from the Leiden University Medical Center (LUMC) have published an…

Studying surfaces of solid materials: it may not seem relevant to energy consumption, but it is. Marcel Rost studies how platinum electrodes wear out. Those electrodes are a crucial component in the fuel cells of hydrogen-powered cars. ‘We need to make the switch from fossil fuel energy to hydrogen.…

Dying from viral infection due to organ failure and blood loss: we still know little about how it can happen. Among other things, Huaqi Tang developed an organ-on-a-chip to figure it out. 'These technologies can offer unprecedented opportunities to fight the viruses that threaten our society.' Tang…

In a supplementary decision on 17 May 2022, the Executive Board of Leiden University has concluded that it will publish the titles of seven articles in which there is evidence of malpractice. This concerns a former staff member of the Institute of Psychology. The Executive Board considers it to be in…

Historic and iconic yet expensive and cold. It’s with mixed feelings that the university is leaving the Gravensteen building, which dates back to the 12th century. How was it to work and study in this former Leiden prison?

The AtheroNeth consortium received €6 million from the Dutch Heart Foundation to gain a better understanding of the differences in disease progression among patients with atherosclerosis. The ultimate goal is to enable personalised treatment.

It was with great sadness that on 17 May 2021 we learned of the death of our dear colleague Paul Valk. Paul died from the consequences of COVID-19, having been diagnosed with coronavirus over three weeks ago. Soon after this he was admitted to intensive care, where he was kept in an induced coma on…

Understanding the proces of electrochemical reactions is essential to improve the technology for the energy transition. Fuel cell cars, for example use hydrogen produced from the electrolysis of water. Mariana Monteiro did fundamental research on the process and won two prizes with her thesis.

Swarms of drones, pedestrians or the cells in your body. Those are all examples of active matter: materials whose building blocks can move autonomously. That’s what Luca Giomi studies. Giomi has been appointed Professor of theoretical physics in the area of soft matter and biological physics at the…

The challenge is considerable, but so is the satisfaction when it succeeds: creating complex sugar molecules that play a role in biology.

To understand how the brain works, it is essential to map it out in detail. This appears to be possible with a microscopy technique in which Leiden physicists excel. This breakthrough could significantly advance the human quest to understand brain functions.

Acute stress seems to have a surprisingly positive effect on our health. Researcher Erin Faught received an NWO veni grant to find out why that is and how we can use that knowledge to our advantage. For her lab research, she uses a remarkable small animal to learn more about our own stress levels.

Jasper Knoester started on 1 January as our new dean. How is he finding it, what kinds of things is he doing and what does his day look like? In every newsletter Jasper gives us a peek into his life as dean.

From social inequalities in prehistory to placebo effects in medical treatments. Four researchers from Leiden University have been awarded a prestigious ERC Advanced Grant worth EUR 2.5 million to develop their research.

Genes predict whether you have a propensity for an illness but environmental factors often have the last word: nutrition, air pollution, lifestyle, stress. The exposome as both culprit and chance. Large-scale research is being carried out into this at Leiden. Thomas Hankemeier, Professor of Analytical…

On 28 September the famous chemists Carolyn Bertozzi visited Leiden University to speak at the LED3 seminar. Just one week later, she was announced winner the 2022 Nobel Prize in Chemistry. Leiden chemists Sebastian Pomplun and Hermen Overkleeft are fan: ‘We are extremely honoured to have hosted this…

Already during their bachelor’s programme, students in Pharmaceutical Sciences are presented with challenging projects. One of these is the Bachelor Research Assignment (BOO in Dutch), which is often their first real experience with scientific research. This means a lot of responsibility and failures,…

Prof. Marcel Reinders is a data science specialist at Delft University of technology. Using smart algorithms, he searches for links in complex data. For example, he studies patterns in DNA that lead to aberrant cell behaviour. This knowledge will help detect serious diseases such as Alzheimer's and…

A Dutch consortium has received €6.7 million to accelerate the development of nanomedicines together with patients. Researchers from Leiden University play a key role in the project.

Skåne University Hospital, Lund University and Leiden University Medical Center will work together to expand their research, teaching and development relating to Advanced Therapy Medicinal Products. That is the essence of a Memorandum of Understanding signed at SciLifeLab near Stockholm on Wednesday…

A single tiny molecule that can destroy flu, corona, HIV and Zika viruses? Yes, it really does exist. Biophysicist Niek van Hilten, who will receive his doctorate on 14 September, contributed to this discovery.

An impressive 12 researchers from Leiden University have been awarded an 800,000-euro grant by the Dutch Research Council (NWO). This will enable them to develop their own line of research over the next five years.

‘By cleverly combining new techniques for analysing DNA at the level of individual molecules, we can achieve real breakthroughs in research into conditions such as dementia,’ predicts Professor John van Noort. Together with four leading biophysics research groups, he has written a review article in…

By day, Roeland Merks works on mathematical models that describe cells and complex systems. In the evenings, he opens the door to a different world. In his home and art space De Spelonk, contemporary art, experimentation and curiosity come together — right at the intersection with his scientific per…

As of 1 September, Jeroen van Zon started as professor by special appointment in Quantitative Developmental Biology at the Institute of Biology Leiden (IBL). Van Zon is also group leader of Quantitative Developmental Biology at the physics research institute AMOLF. Three questions about his new role…

Developing a better treatment for patients with head and neck cancer, that is what Binanox, The 2022 iGEM Leiden team, want to achieve. They hope to raise at least 10,000 euros for this cause. Support their crowdfunding campaign today.

LION

PhD candidate Sibel Bahtiri is one of the new Faces of Science. In videos and blogs, she will show what life is like as a young researcher.

The European Research Council (ERC) has awarded Nathaniel Martin a Proof of Concept (PoC) grant. With it, his group aims to make a dangerous but potent antibiotic less toxic. He receives €150.000.

During the LACDR Fall Symposium, Scott Engels received the Suzanne Hovinga Award for the ‘best master thesis’. Scott performed his RP1 research under the supervision of Dr. Amanda Foks and Virginia Smit in the Aging and Immunity group at the division of BioTherapeutics.

On March 1st, Laura Bosmans has started as Assistant Professor in the Division of BioTherapeutics working with Ilze Bot, Bram Slutter and Amanda Foks. Laura finalised her study Bio-Pharmaceutical Sciences in 2017, after which she completed her PhD at the University of Amsterdam, location AmsterdamUMC…

This week, we are hosting the ULLA workshop 2023. We are proud partner of the ULLA. It is the European University Consortium for Pharmaceutical Sciences in which LACDR participates for already 30 years.