During illness, the stiffness or viscosity of cells can change. Tom Evers demonstrated this by measuring such properties of human immune cells for the first time. ‘The stiffness of certain cells could be a way to make a diagnosis,’ Evers said. He defended his thesis on March 26th.

Researchers at Leiden University have created a unique model that mimics how disease develops after a dengue infection. This 'dengue-on-a-chip' model helps them study the virus more effectively. The timing is crucial, as climate change is causing dengue to spread worldwide.

In a project funded by the John Templeton Foundation to the group of Micha Drukker, scientists will produce stem cells from short and long living understudied species to model cellular and organismal lifespan.

More than 700 visitors got to know the Science Faculty during the Leiden Science Family Day. People of all ages could enjoy fascinating experiments, tours, interesting lectures, spectacular nitrogen shows and various workshops. It was an informative day with many (future) scientists, amazement and,…

Physicist Milan Allan will build an instrument that will bring superconductivity research further. He has been awarded an ERC Consolidator Grant of 2 million euros over the next five years. With his PairNoise programme he aims to detect paired electrons as they occur just above the temperature at which…

For the first time, an international team of scientists led by Leiden Observatory and SRON can explain the extreme jet streams observed around the equators of all the giant planets using a single model.

Research

Metamaterials researcher Martin van Hecke has been elected American Physical Society (APS) fellow, an honour exclusive to only half a percent of the society's members.

Dr Ilze Bot (LACDR) has been appointed professor of Cardiovascular Pharmacology with effect from 1 March. A recognition of her work as a scientist. 'This allows me to continue and expand my line of research within the LACDR and Leiden University.'

This March, Jara Bouma, Cas van der Horst and Laura Heitman from the Division of Drug Discovery and Safety and Laura de Paus, Richard van den Berg, Anthe Janssen and Mario van der Stelt from the LIC joined forces to determine how some drugs can specifically target the cannabinoid CB2 receptor (CB2R)…

Mechanics play a larger role in blood vessel formation, and other developmental biology, than previously thought. Cells appear to respond to mechanical signals, such as pressure. Through the extracellular matrix, a network of fibrous proteins, cells can supposedly exchange those mechanical signals over…

I am thrilled to share the exciting news of being honored with the 2023 Early Career Award at the EUROTOX conference held in Ljubljana, Slovenia. This recognition, presented by ECETOC (European Centre for Ecotoxicology and Toxicology of Chemicals) and dedicated to the memory of Dr. Christa Hennes, holds…

Plant biologist Pingtao Ding, assistant professor at the Institute of Biology Leiden (IBL), has received a 2.4 million European grant from the European Research Council (ERC). This ERC Starting Grant for promising young researchers allows him to unravel the molecular mechanisms by which plants resist…

Leiden researchers have found clues to why a rare pregnancy disorder is mild in some babies but life-threatening in others. Their discovery opens the door to a test that could identify severe cases during pregnancy. Fortunately, a treatment already exists.

Cancer immunotherapy represents a significant breakthrough in cancer treatment. However, tumors have numerous mechanisms by which they evade destruction by the immune system. It is therefore necessary to decipher and reverse these mechanisms in order to improve immunotherapies.

Despite considerable progress in the design of multifunctionalized nanoparticles (NPs) that selectively target specific cell types, their systemic application often results in unwanted liver accumulation. The exact mechanisms for this general observation are still unclear.

Sebastian Pomplun receives an ERC starting grant of 1.85 million Euros in five years. He wants to develop synthetic transcription factors that can enter cells and activate or deactivate specific genes. For example to disrupt cancer-related processes or to trigger the production of an important missing…

On 28 September the famous chemists Carolyn Bertozzi visited Leiden University to speak at the LED3 seminar. Just one week later, she was announced winner the 2022 Nobel Prize in Chemistry. Leiden chemists Sebastian Pomplun and Hermen Overkleeft are fan: ‘We are extremely honoured to have hosted this…

Ten Leiden researchers have been awarded a Veni grant by the Dutch Research Council (NWO). The grant, of up to 280,000 euros, will enable them to elaborate their ideas over a period of three years.

An all-optical transistor, a molecule-sized sensor and a new kind of single-photon source for quantum communication. All dreamed applications of fundamental physics that are one step closer thanks to Robert Smit. On 12 June, he defended his PhD thesis with distinction.

Leiden University is introducing 15 interfaculty themes to improve its visibility and strategic positioning. These themes can now be found on our website.

Tuberculosis stands as one of the most lethal infectious diseases worldwide. A significant challenge in combatting tuberculosis lies in the emergence of antibiotic resistance triggered by genetic alterations, commonly known as mutations. These mutations can diminish the responsiveness to antibiotics,…

When the tokay gecko loses its tail, a new one grows from resident stem cells at the stump. Each tissue type - muscle, bone, blood vessels and skin - develops from specific stem cells. This discovery by Luthfi Nurhidayat holds potential implications for advancing regenerative medicine in humans. Nurhidayat…

Luca Giomi has the first results of his ERC consolidator grant. He discovered that epithelial cells move collectively but in different ways, depending on the scale you look at. It is hexatic at small scales, and becomes nematic at larger scales: it is a multiscale order. This collective movement of…

Nano-plastics cause malformations. Meiru Wang, researcher at the Institute of Biology Leiden, looked at the extreme effects polystyrene nano-particles could have, using chicken embryos as a model. Her results were quite alarming. Especially as nano-particles are everywhere. In the air, floating through…

Amidst the lathes and welding machines of the Fine Mechanics Department, Emiel Wiegers is working concentratedly on a metal cylinder. He and his colleagues design and construct components for researchers' set-ups. ‘We are a bunch of inventors who enjoy helping the researchers in our Faculty.’

Human cells are protecting their proteins from unfolding and aggregating. That's what biophysicist Alireza Mashaghi and his team discovered after seven years of in-depth research into the folding mechanisms of proteins. With an unprecedented approach, the team was able to study the folding of a single…

Acute stress seems to have a surprisingly positive effect on our health. Researcher Erin Faught received an NWO veni grant to find out why that is and how we can use that knowledge to our advantage. For her lab research, she uses a remarkable small animal to learn more about our own stress levels.

The fact that scientists are increasingly better able to access molecular cell and tissue data also brings with it a new challenge: how can scientists find the information they need for research among the vast amount of data available?

Recently, our respected and talented former colleague Bente Hilde Bakker passed away after a long and brave fight with illness. She received her mathematical training at the Vrije Universiteit in Amsterdam and also obtained her PhD there under the supervision of Jan Bouwe van den Berg and Robert van…

Our lecturers are back on campus sooner than the rest of the staff. Away from their screens and in live contact with students: many lecturers are relieved, but some are concerned. Have sufficient steps been taken at our teaching locations? What about ventilation? We spoke to Michel Leenders who, as…

Developing new drugs is a difficult process. With the aid of artificial intelligence, Pharmaceutical scientist Xuhan Liu has developed methods that can help make drug design cheaper and faster. PhD defence on 15 February.

Jasper Knoester is the dean of the Faculty of Science. How is he doing, what exactly does he do and what does his day look like? In each newsletter, Jasper gives an insight into his life.

This summer, one of our BPS-master students, Ramazan Kiliç, will travel to Baltimore to present his research at the annual ARRE Research Symposium, a conference on ASXL-disorders that attracts researchers from all over the world, including the US, Japan, Germany, Ireland and, of course, The Netherlands.…

Why are mycobacteria such successful pathogens? And are there defence mechanisms in the body that help reduce an infection? To find out, Annemarie Meijer has been awarded the NWO Open Competition ENW-XL grant. She will not explore this quest alone. Five other leading Dutch research groups are participating…

About one and a half million people worldwide die each year from tuberculosis. For thirty years, therapy with antibiotics has been the same, while it takes far too long and can lead to resistant pathogens. Leiden researchers from four institutes are now joining forces to develop more effective and efficient…

They are among the rarest and most extremely luminous stars in our universe: yellow hypergiants. Their spectacular eruptions have intrigued astronomers for decades, and now an international team led by Leiden’s emeritus professor Arnout van Genderen has gained new insights into the mechanisms behind…

Lecture

SRON, the Netherlands Institute for Space Research, is holding an open day on Sunday 25 September. It has had a branch at the Leiden Bio Science Park since 2021 and works closely with Leiden University.

On January 24 Professor Annemarie Meijer and Dr Sander Wezenberg received a NWO grant for their research. The grant was awarded within the Open Competition Domaine Science-M programme and is intended for innovative research areas that can form the basis for the research themes of the future.

On behalf of the interdisciplinary programme Social Resilience & Security, we would like to remind you of the call for proposals for seed funding (up to €4.000) to boost interdisciplinary research.

Micha Drukker

Two research projects with researchers from Leiden University have been awarded a Dutch Research Council (NWO) Open Competition Domain Science-M programme grant. These grants fund curiosity-driven, fundamental research in the Science domain.

Could water be present in planet-forming disks before the formation of rocky planets? The James Webb Space Telescope may have found evidence for that. Webb has for the first time observed water in the inner disc around young star where at greater distance, giant planets have already formed. The research…

On 22 November, Leiden scientist Jan Vonk received an ERC starting grant for his research on the building blocks of mathematics. This grant is not his first this year: in fact, this July Vonk also received a Vidi from NWO. Four questions to the scientist who got two grants this year.