The Leiden Index of Depression Sensitivity (LEIDS) measures cognitive reactivity (CR) to sadness, an aspect of cognitive vulnerability to depression, conceptually similar to rumination.

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The SPS Monitor measures your sensory stimulus sensitivity. Sensory stimulus sensitivity refers to one's sensitivity to subtle environmental stimuli, the depth and intensity with which these stimuli are processed and the impact this has on one's functioning.

A tidal basin is an inland sea which is almost entirely enclosed by land and connected to the open sea by a tidal inlet. Through the tidal inlets interaction takes place between the tidal basin and the open sea.

A research goal for ABS is to develop miniaturized platforms for research in (stem)cell, in-vitro systems and application in clinical and preventive research. Combined with the high throughput, this development will make it possible to study the dynamics of pathogenesis in human and cellular models…

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

The transition period in which men become fathers might provide an important window of opportunity for parenting interventions that may produce long-term positive effects on paternal care and, consequently, child development. Existing prenatal programs traditionally focus on maternal and infant health…

Source: Nature Biotechnology, Volume 2014, Issue June (2014)

With increasing carbon dioxide levels in the atmosphere and their detrimental effect on the global climate, modern society needs to push for more renewable energy sources. Storing widely accessible and abundant solar energy in chemical bonds in the form of molecular fuel via artificial photosynthesis…

Human vocal communication and music perception represent advanced cognitive skills, seemingly innate and universal. These faculties encompass a range of perceptual and cognitive abilities. Cross-species research sheds light on the origins of musicality by investigating whether these traits are shared…

The aim of this work was to study the applicability of antigen-coated pH-sensitive microneedle arrays for effective vaccination strategies. Therefore, a model antigen (ovalbumin) was coated onto pH-sensitive (pyridine-modified) microneedle arrays to test pH-triggered antigen release by applying the…

A meeting place for singing parrots. That is one of the ambitions of Michelle Spierings’ new project. With her awarded NWO XS grant, she wants to test the parrots’ hearing ability. ‘I am curious to see how they can recognise and imitate changing melodies. And it would be amazing to test that with a…

Moving an electron microscope of 2000 kg is a delicate challenge. The highly sensitive instrument needed to be moved to a new measurement hall, but even a tiny bump could damage it. After a few nerve-racking weeks of preparing the move and reinstalment, the researchers finally have a verdict: the instrument…

PhD candidates from Institutions for Conflict Resolution (COI), Eva Grosfeld (Leiden University), Marlou Overheul (Utrecht University), and Amarins Jansma (social psychology, Utrecht University), won the KLI seed money grant for research on the influence of politically sensitive cases on public trust…

A study on the development of prosocial behaviour.

An international team of astronomers has published the most sensitive images of the Universe ever taken at low radio frequencies, using the International Low Frequency Array (LOFAR). ‘LOFAR is unique in its ability to make high-quality images of the sky at metre-wavelengths’, said Huub Röttgering, Leiden…

Students from Leiden University have launched The Nuance Project, a platform for respectful, open-minded dialogue on divisive issues. The aim is to foster connection and understanding among people even if their viewpoints differ.

Research conducted by Dutch news programme ‘Nieuwsuur’ into the work carried out by Princess Laurentien of the Netherlands for victims of the childcare benefits scandal raises many questions. Legal experts are puzzled as to how the Cabinet at the time assigned the tasks. Geerten Boogaard, Professor…

Reducing greenhouse gas emissions is one of the most pressing challenges that humanity faces in the coming decades.

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

Lecture, Com(parative) Syn(tax) Series

A framework for prospective/ex-ante life cycle assessment (LCA) and ecological risk assessment (ERA) of emerging technologies is developed and applied to a case study of III-V/silicon photovoltaic panels.

This thesis discusses the discovery potential of Intensity Frontier experiments.

How politically sensitive cases affect public trust in judges

Promotor: E. Bouwman Co-Promotor: S. Bonnet

Promotor: T. H. Oosterkamp

This dissertation explores new chemical strategies for the synthesis of self-adjuvanting peptide conjugates and immunomodulatory ligands aimed at targeted activation of the immune system.

One of the key quests in astronomy is to study the growth and evolution of galaxies across cosmic time. Radio observations provide a powerful means of studying the formation of stars and subsequent buildup of distant galaxies, in a way that is unbiased by the presence of dust.

Social aspects of the learning environment, also called classroom climate, are important for students’ cognitive and affective learning outcomes. In this thesis the classroom climate is operationalised by means of two components: the teacher-class relationship and classroom discipline.

Mapping the neural mechanisms underlying social motivations of adolescents and adults

This thesis investigated miniaturized mass spectrometry (MS)-based analytical methods to address challenges in analyzing biomass-restricted biological samples.

Cardiovascular diseases (CVDs) are the leading global cause of mortality. Endothelial dysfunction, an early reversible stage of CVD development, is marked by decreased nitric oxide production linked to Ca2+ influx in endothelial cells.

Thirty years ago, mutations in the BRCA1 gene were first linked to hereditary breast and ovarian cancer, establishing a genetic basis for cancer development.

Making sensitive data reusable through synthetic data generation

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A lot of our research is performed at temperatures close to absolute zero, among other reasons because this increases the sensitivity of the measurements. 

Agrobacterium-mediated transformation (AMT) has abundantly been used for scientific research for identifying valuable traits.

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

How is the development of physiological responses to social evaluation in adolescence affected by other normative developments, such as pubertal, socio-cognitive and psychosocial development? Are social anxiety and public speaking anxiety associated with characteristic patterns of stress responses…

Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.

Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

What is the neural basis of social decision-making across childhood, adolescence and adulthood and what are the developmental patterns in terms of behavior and brain activation?

The external tissues of plants and animals are colonized by microbial communities termed microbiota. When organisms are exposed to environmental pollutants, these substances will therefore encounter microbiota at the exposure interface.