N-acylethanolamines (NAEs), including N-arachidonoylethanolamine (anandamide, AEA), N-palmitoylethanolamine (PEA) and N-oleoylethanolamine (OEA), are signaling lipids that play an important role in different physiological process.

How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?

The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.

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Investigating neurobiological endophenotypes of Social Anxiety Disorder

Leiden researchers have found clues to why a rare pregnancy disorder is mild in some babies but life-threatening in others. Their discovery opens the door to a test that could identify severe cases during pregnancy. Fortunately, a treatment already exists.

Only one in five young people with emotional health problems such as an anxiety disorder receives appropriate professional help. GPs often fail to properly recognise the signals in children and young people, according to psychologist Semiha Aydin. How can we improve this? PhD defence 23 February.

Do general practitioners recognize children with or at risk of problematic anxiety and is there a pattern that might help differentiate those with and without anxiety disorders in general practice?

Professor of Human Genetics Willeke van Roon will give her inaugural lecture on Monday 28 March entitled: ‘Translational research, where small parts make the bigger picture.’ She will emphasise how university medical centres should take responsibility for finding treatments for very rare diseases.

Children with autism spectrum disorder experience serious challenges in social functioning, which threatens their development in many areas of functioning.

Bringing your drug candidates to patients is what many academic chemists dream about, but the road to this goal is long and bumpy. Now, Leiden small molecule nizubaglustat is ready for phase 3 clinical trials. This is thanks to a €132 million funding secured by the biotech spin-out Azafaros.

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

What physics controls the properties of quantum matter, such as how electrons flow inside high-temperature superconductors? This question has captivated the physics community and industry for decades, in part due to the great technological potential such materials have, but also because they have resisted…

The use of the pill, in combination with genetic factors, can influence experimental psychological research in women. More research is needed into the influence of the pill on mood disorders, concludes psychologist Daniëlle Hamstra. PhD defence on 30 September.

An international mega-analysis on the neurobiological link between inhibited temperament and social anxiety disorder

To get a feeling of how we operate at LED3 when it comes to Early Drug Discovery, please browse through our case studies. When you select a case study you’ll find relevant contacts.

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The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

Disinformation has become a popular subject of study and debate. A plethora of publications and policies have emerged, aiming to analyse and curb the negative consequences of unwanted communication.

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

This project has two main aims: I. Determine when novelty promotes fear extinction. II. Discover the neurobiological mechanisms underlying these effects.

If you know a crime is about to occur, should you be able to prevent it before it has even happened? This was one of the questions that was posed in light of predictive policing as a form of mass surveillance during the debate in the elective Governance of Crime and Social Disorder class of the Crisis…

Today, ESA’s Gaia mission releases its new treasure trove of data about our home galaxy. Astronomers, led by the Leiden astronomer Anthony Brown, describe strange ‘starquakes’, stellar DNA, asymmetric motions and other fascinating insights in this most detailed Milky Way survey to date.

What is the role of stress and stress-related hormones in emotion regulation?

Delineating psychophysiological endophenotypes of social anxiety disorder

Can epigenetic changes explain associations between early life stress and health outcomes?

Brain development in children with an extra X chromosome as compared to children with autism: evidence from MRI

Teacher Dr. Elke Devroe introduces group role-play on actual themes of governance of crime and social disorder. Seven groups of 5 students each presented last Tuesday March 17th pro’s and con’s of the topic of their choice in a panel in a TV-show setting. Students enjoyed lifting green and red cards…