226 search results for “zebrafish” in the Public website
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The role of the tumor suppressor Lkb1 in energy homeostasis
The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.
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Innate immune defence against intracellular pathogens
What are the host immune defence mechanisms that control intracellular infections and how are these subverted by pathogens?
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Key innate immune components controlling intracellular infection
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer
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Animal Sciences
We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.
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Glucocorticoid modulation of the immune response
Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.
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Exploitation of host chemokine signalling by pathogenic mycobacteria
Promotores: A.H. Meijer, H.P. Spaink
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Hildert BronkhorstFaculty of Science
h.bronkhorst@biology.leidenuniv.nl | 071 5274964
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Exploring the mechanisms of metastatic onset for novel treatment strategies
This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.
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NWO grant for super fast analysis of disease progression
New funding allows IBL-researcher Herman Spaink to purchase a measurement device for more studies on human diseases such as cancer and tuberculosis using zebrafish as the model system.
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Michael RichardsonFaculty of Science
m.k.richardson@biology.leidenuniv.nl | 071 5275215
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Illuminating Host Defence against Mycobacterial Infection: Interactions with Autophagy and LC3-Associated Phagocytosis
Despite substantial progress in understanding tuberculosis (TB), the eradication of the TB epidemic is still far from reach.
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Saloni SaxenaFaculty of Science
s.saxena@biology.leidenuniv.nl | 071 5274950
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Margo DonaFaculty of Science
m.a.dona@biology.leidenuniv.nl | 071 5272727
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Ana Cristina Arcos MarinFaculty of Science
a.c.arcos.marin@liacs.leidenuniv.nl | 071 5272727
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Ruthenium-peptide conjugates for targeted phototherapy
As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.
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High-throughput profiling of small molecules using mass spectrometry
Promotor: Prof.dr. T. Hankemeier, Co-Promotor: R.J. Vreeken
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New techniques for tuberculosis treatment
About nine million people worldwide contract tuberculosis each year. Research into new treatment for this disease has received fresh stimulus with more efficient techniques and a new understanding of how the tuberculosis bacteria works.
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INFLANET - Training European Experts in Inflammation: from the molecular players to animal models and the bedside
How is inflammation in tuberculosis controlled by interplay between autophagy and inflammasome signalling?
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Inaugural lecture Annemarie Meijer
On Monday 21 September Annemarie Meijer, Professor of Immunobiology, presented her inaugural lecture on immunobiology and infectious disease.
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Animal sciences and health
In the research theme ‘Animal Sciences and Health’, we work with various animal species to gain insights into fundamental biological processes in both animals and humans.
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Christian TudoracheFaculty of Science
c.tudorache@biology.leidenuniv.nl | 071 5274759
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Zebrafish against cancer
Valedictory lecture
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Horizon2020 grant for toxicologist Bob van de Water
An international research consortium led by Bob van de Water, Professor of Toxicology at Leiden University, has been awarded a prestigious Horizon2020 grant of 30 million euros.
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Studies on the Pathogenesis of Chronic Kidney Disease
In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…
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Host-Microbe Interactions in Animal Sciences
Animal Sciences’ contributions to the Host-Microbe Interactions research theme focus on the interaction of animal hosts with pathogenic microbes but also the beneficial role of the gut microbiome.
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Research
Tuberculosis causes 1.5 million deaths yearly and anti-tuberculosis therapies are threatened by emergence of drug resistance. Development of innovative drug combinations should be accelerated with the use of translational pharmacological models. Moreover, host-directed therapies (HDT), which stimulate…
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The innate immune response against mycobacterial infection: analysis by a combination of light and electron microscopy
Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn, Co-promotor: Dr. M.J.M. Schaaf
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Bioactive Molecules in Animal Sciences
Animal Sciences’ contribution to the Bioactive Molecules research theme includes research on molecules from natural sources, such as plants, insects, and snake venom, with the aim to identify novel anti-cancer, anti-inflammatory, anti-microbial, and anti-diabetic agents.
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Ecotox
Ecotox is a stimulating top-facility that provides an integrative research environment around the topic of ecotoxicological testing and experimental research. Research focus: Dose-response modelling Mode-of-actions and mechanism-of-actions Test method development, in view of targets in AOPs (adverse…
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Aggressiveness of cancer cells halted
Zebrafish-human communication shows that cancer cells lacking a signaling protein are less able to develop aggressive metastatic properties. This discovery has been made by molecular cell biologist Claudia Tulotta. PhD defence 14 June.
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Host-Microbe Interactions
Microbes influence and respond to other organisms. This theme explores the dynamic relationships within plant and animal microbiomes, and the immune responses that govern host defense. Using model systems such as zebrafish, insects, and plants, we investigate fundamental processes and engineer microbes…
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White blood cells in transparent embryos
Leiden molecular cell biologists in the research group of Annemarie Meijer have discovered novel early macrophage-specific genes in zebrafish, including a signal transducer pivotal for the migration of macrophages in the innate immune response to bacterial infection. Their findings were published on…
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Development & Disease in Animal Sciences
Animal Sciences’ contributions to the Development & Disease research theme include the mechanisms and evolution of embryonic development, the development of cognitive mechanisms, and animal models for understanding mechanisms of human disease.
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Rationally designed peptide based functional biomaterials
Promoter: J.G.E.M.Fraaije, Co-promotor: A. Kros
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Mesoporous silica nanoparticle-based protein delivery systems for biomedical applications
Promotor: A. Kros
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Shape Analysis for Phenotype Characterisation from High-throughput Imaging
We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.
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Computational optimisation of optical projection tomography for 3D image analysis
Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.
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Evolutionary Developmental Biology of Bitterling Fish
We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…
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Investigating lipid formulations for efficient RNA delivery using zebrafish models
PhD defence
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Development & Disease
Living systems scale from unicellular microbes to complex multispecies communities that constantly change over time. Within the theme Development & Disease, we enhance our fundamental understanding of development and homeostasis of living cells and systems. We analyze the normal situation and how stresses…
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Patrick van HageFaculty of Science
p.van.hage@biology.leidenuniv.nl | 071 5274950
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Gitlab
GitLab is a single application for the entire software development lifecycle. We use the Leiden University gitlab services
- Facilities
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Facilities
Our facilities cover:
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Macrophages as drivers of an opportunistic infection
The opportunistic bacterium Burkholderia cenocepacia is feared by cystic fibrosis patients and is emerging in hospital-acquired infections. An international study sheds new light on the infection mechanism of this opportunistic pathogen that may have large implications for treatment strategies.
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Marcel SchaafFaculty of Science
m.j.m.schaaf@biology.leidenuniv.nl | 071 5272727
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Health research and expertise at the IBL
We investigate the molecular basis underlying health and disease and provide answers to existing and emerging health problems. Within this theme, we study diseases ranging from rare genetic disorders to cancer and infectious diseases. We make use of a wide variety of model systems and pursue diverse…
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Evaluation of synergistic effects of Chinese herbal medicine and natural compounds on cancers
What are the biological effects of Chinese herbal medicine in regulation of cancer cell metastasis?
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Publications
For a full overview of the publications of the Translational Immuno-Pharmacology group, visit the Google Scholar page.
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Novel immunomodulatory drugs for tuberculosis treatment
Can drugs that target host signaling pathways be used to eradicate antibiotic-resistant bacteria?