Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…

Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.

Extending our current arsenal of antibiotics is key to staying ahead in the arms race between humans and resistant bacteria.

Photocatalysis has emerged as a powerful tool for enabling challenging transformations in organic synthesis. This thesis explores the development of several photocatalytic reactions designed to form carbon-heteroatom bonds from less-functionalized precursors.

The electrochemical hydrogenation reaction is an alternative approach for the transformation of unsaturated bonds without the use of flammable dihydrogen gas.

This thesis highlights the significant role of surface geometry and oxidation state in determining CO adsorption behavior on copper surfaces.

In this thesis, time-lapse fluorescent microscopy plays a pivotal role in investigating functional materials within living cells as well as the migratory behaviour of neural progenitor cells.

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

This dissertation investigates the propagation of solitary waves in the presence of random disturbances.

In this PhD thesis, available data on the PK and/or PD of different targeted therapies, chemotherapy and immunotherapies obtained during both routine clinical practice and prospective clinical studies were analyzed.

PhD defence

PhD defence

Doing a PhD at the Institute of Psychology can be an exciting experience. On this webpage we provide you with the necessary information on application, registration, the Graduate School and Training and regulations. Leiden University’s Institute of Psychology offers you a professional and supporting…

Find out how the admission procedures for PhD candidates at LUCAS are structured.

The two-year Research Master in Asian Studies equips you with advanced and in-depth knowledge of a region and discipline within the field of Asian Studies.

The Institute of Cultural Anthropology and Development Sociology (CADS) of Leiden University hosts almost 50 PhD candidates working on a wide variety of topics.

On this page you can find out more about applying for a PhD position at the Faculty of Humanities.

Thank you for your interest in doing PhD research at the Leiden Graduate School of Humanities. Below you will find information on how to start your PhD at Humanities in Leiden.

The overall aim of the project is to investigate interests and their development over time in a daily life context, with particular attention for the transition from late secondary to post secondary education, and from late post secondary education to early career.

Diversity and inclusion are core values of Leiden University. Leiden University has committed itself to a policy that aims to become an inclusive community which enables all students and staff to feel valued and respected, and to develop their full potential. The Diversity & Inclusion Expertise Office…

On the 9th of June Bahaddin Budak successfully defended a doctoral thesis and graduated.

How do teachers conceptualise, develop and implement an effective CLIL practice?

The Dutch Research Council (NWO) offers two grants that may support PhD candidates.

The research addresses the question of “what is the impact of geopolitical changes to the pivot states in the Middle East? With special focus on Turkey, Iran and Saudi Arabia.”

Music profession requires strong reflective, collaborative, creative and improvisational skills, yet prevailing one-to-one tuition in conservatoire education focuses mainly on transmission of craft skills. Examining effects of students' collaborative and experiential learning, as in learning labs, creates…

Reflective dialogue is an effective instrument for professional learning of teachers. This research considers the characteristics, development, stimulating and limiting conditions for reflective dialogues in the context of Dutch primary school teachers who collaborate and learn together. The goal is…

In a virtual game environment, one of the positive effects of anonymity is the absence of one's prejudice toward others, which can give a person the freedom to change and experiment (Bartle, 2003). This project will adopt anonymity to be added to online cross-cultural collaborative learning in higher…

Towards a framework that integrates content-based and process-based accounts of mathematical thinking

What is the optimal way to utilise intermediate assessment in improving study behaviour and study success?

Open Educational Resources (OER) have the potential to change teaching in Higher Education, but adoption is low despite the growing amount of resources available. The current project aims to investigate if and how teacher communities can foster adoption of OER in curricula.

This project focuses on vocational teachers’ professional development in work placement. Teachers’ learning motivation, learning experience and learning outcomes within work placement will be explored in depth.

Which basic characteristics and skills and knowledge influence the use of and actions based on real-time student data presented on a teacher dashboard in primary education?

How do students’ interests develop over time and which interests are subsequently pursued in the higher educational choice of students?

Language learners in higher education increasingly conduct out-of-class self-directed learning facilitated by mobile technology. This project aims to explore how university students use mobile technology for their self-directed language learning and investigate factors that influence their self-directed…

How can we gain insights in the connection between teaching practices and theoretical elaborations of purposes of education?

University-school partnerships are important constellations for teachers’ professional learning. The present study investigates how both teacher characteristics and contextual factors are related to teachers’ motivation to participate in the university-school partnership, and the relationship between…

In the field of Western art music, improvisation has become a much discussed topic. In this interdisciplinary study I argue that in this context, improvisation is not to be seen as a quasi-autonomous skill or art form, but as an aspect of music-making in general.

A lecture about the drive, dynamics and dilemmas of our central bank and supervisor. Joanne Kellerman discussed the role of DNB, the central bank in our country for already 200 years, and the dilemmas that a supervisor faces. How can be ensured that a supervisory intervention is rightly timed and that…

The present project aims to provide valuable insights for the professional development of international teachers, and also for improving the quality of foreign language education.

What are relationships between student teachers’ personal characteristics, learning experiences and perception of external environmental aspects impacting teacher career and their commitment to teaching?

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

The Leiden University doctoral / PhD programme takes around four years of study and consists of independent and original research under the supervision of a professor.

Chinese materia medica (CMM), comprising a diverse array of natural substances from plants, animals, and minerals, has been integral to Traditional Chinese Medicine (TCM) throughout history. This study investigates the dynamic evolution of CMM, noting shifts in species for improved therapeutic effects…

This thesis covers several aspects of quantum algorithms for near-term quantum computers and its applications to quantum chemistry and material science.