Leiden scientists are the main applicants for five projects that have been awarded a Science Groot grant of up to 3 million euros in the Science Domain. In addition, several Leiden scientists are involved in other projects that have been awarded funding.

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

This study explores public leaders’ organizational learning orientation in the wake of a crisis. More precisely, we study the association between public leaders’ public service motivation and their learning orientation (instrumental versus political).

Understanding the behaviour of tiny droplets in our cells could aid the search for new treatments. A team of Leiden researchers has developed a groundbreaking method to study how these droplets transition from liquid to solid. This change plays a role in various diseases, including neurodegenerative…

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…

Research at the Macromolecular Biochemistry group is comprised of the following research themes:

Beneficial plant-associated microbiota, particularly those inhabiting the rhizosphere, contribute substantially to plant health through pathogen suppression, stimulation of plant defence responses, and enhanced nutrient acquisition.

Promotores: Prof.dr. C.U. Keller, Prof.dr. H.C. Gerritsen

Transcutaneous vaccination is attractive because it is non- or minimally invasive, pain free and the site of administration (skin) is easily accessible. What’s more, transcutaneous immunization can lead to a strong immune response owing to the presence of immune-competent cells in the skin.

PhD defence

Learning from nature and utilizing microbial biodiversity to identify and characterize enzymes for degradation and upcycling of plastics and other polymeric materials.

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

In the research programme Microbial Sciences we perform state-of-the-art research in the field of biotechnology and microbial sciences.

The high prevalence of pure red cell aplasia in Thailand has been associated with the sharp increase in number of recombinant human erythropoietin (rhEPO) copy products, based on a classical generic regulatory pathway, which have entered the market.

Heart failure is a major health care problem with high mortality.

Do you have questions about the Astronomy master’s programme? Please contact us.

Do you have questions about the Astronomy master’s programme? Please contact us.

Developing new medicines is one of modern science's most significant hurdles, a process marked by high costs, long timelines, and frequent failures of promising candidates.

Promotor: S.M. Verduyn Lunel, Co-promotor: O.W. van Gaans

Psycho-physiological reactions to stress.

Promotores: Wim Jiskoot; Ferry Ossendorp

Understanding DNA repair mechanisms is essential for advancing plant biotechnology and crop improvement. This study investigates how double-strand breaks (DSBs), induced by CRISPR/Cas systems, are repaired in the model plant Arabidopsis thaliana, and how these processes influence Agrobacterium tumefaciens…

The current hepatitis B vaccines need to be stored and transported under refrigerated conditions (2-8 degrees C). This dependence on a cold-chain is highly challenging in areas where hepatitis B virus infections are endemic.

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In this article, Sanneke Kuipers and Machiel van der Heijden examine how patterns of policy inaction emerge in public organisations, arguing that systematic biases and organisational decision premises contribute to the failure of policymakers to address pressing societal issues.

The ERC has awarded a Starting Grant to five promising researchers from Leiden. Two are from the Faculty of Social and Behavioural Sciences, one is from the Faculty of Humanities/Governance and Global Affairs, one from the LUMC and one from the Faculty of Science.

Do you have questions about the Master’s specialisation Astronomy and Instrumentation? Please contact us.

From where litter ends up to which languages are spoken in Leiden and The Hague: over 50 interesting, surprising, complex and entertaining questions were sent in for the Citizen Science project to mark our 444th anniversary. Not one but two Citizen Science projects will be starting this year in Leiden…

Do you have questions about the Astronomy master’s programme? Please contact us.

Do you have questions about the master’s specialisation Astronomy Research? Please contact us.

Do you have questions about the Master’s specialisation Astronomy and Data Science? Please contact us!

Do you have questions about the Astronomy master’s programme? Please contact us.

Do you have questions about the Master’s specialisation Astronomy and Education? Please contact us.

Do you have questions about the master’s specialisation Astronomy and Cosmology? Please contact us.

In this study, Bibi van den Berg and Sanneke Kuipers from ISGA, explore the ways in which cyber-related incidents may lead to crises

In this research I assess the impact of the recently discovered gas reserves south off Cyprus on the escalation of the Cyprus conflict.

When researching languages in historical context, our goal is to understand the nature of linguistic variation in the past, and explain the extent to which the socio-cultural context of bygone times contributed to shaping linguistic variation and change.

Engineered nanomaterials (ENMs) are widely used, and nanotechnological innovations grow with rapid pace. Studies on nanotoxicology have demonstrated that chemical toxicology as well as particle toxicology should be accounted for in predicting the safety of ENMs.

In eight chapters, the thesis of Rafaël Vos covers the effect of temperature and pressure on the electrochemical CO2 reduction.

Himalayan environments have changed and continue to change as a result of how people interpret, source, and use them. Scholarly investigation of the induced transformations, whether in deforestation, dam construction, or glacial melt, highlights how man is shaping the world in the Anthropocene.

Since itch and pain can be very burdensome, especially when individuals suffer from (either of) these symptoms chronically, it is important to know the factors by which these sensations are influenced. It becomes more and more clear that psychological factors play an important role in the experience…

The genomic DNA of every organism is organized and compacted in order to fit inside the cell. This is achieved by the joint action of numerous architectural proteins that aid in folding the genome. Genome folding is tightly interconnected with transcription, with genes in certain regions being silenced,…

Improving healthcare with our scientific discoveries: that is the goal of pharmaceutical research at Leiden University. And there’s a lot involved in that. Our research starts with the discovery of the effect achieved by a particular substance, and sometimes continues all the way through to the development…

Promotores: S.J. Edixhoven, F. Andreatta