The coronavirus outbreak has demonstrated the strengths and weaknesses of modern diplomacy. In this two-part series of blog posts, I will attempt to analyze how diplomats grappled with the coronavirus pandemic and how international diplomacy can best prepare to meet similar challenges in the future.…

Linguistic research on a unique collection of Dutch letters allowed us to gain access to the every-day language of people from various walks of life. Private letters by men, women and even children have been elaborately explored in the Letters as Loot researchprogramme, initiated and directed by prof.…

Gathering and distributing patient data can make an important contribution to containing the coronavirus. But if we want to be successful, we need better data. With this objective in mind, Leiden data stewards have joined the Virus Outbreak Data Network (VODAN).

‘The idea that overweight and obesity are the fault of parents and/or the child, is rubbish.' Roxanna Camfferman, who specialises in child and adolescent studies, explains her proposition. Her PhD dissertation is on the role of upbringing in child obesity.

Mashaghi lab conducts research at the interface of physics, engineering and biomedicine. We develop and use theoretical and experimental approaches to address basic and applied research problems.

Meet the scientists within the LED3 community

In recent days and weeks, experts have been falling over themselves to point the finger at the main culprit in the Dutch child benefits scandal. Although this debate is fascinating, equally important are the broader lessons to be drawn from the scandal in relation to constitutional and administrative…

The precise psychobiological mechanisms leading to chronic physiological stress responses have not been sufficiently explained, although stress is a major risk factor for disease and early death. A problem for conventional stress theory is that most of these responses seem to occur in situations without…

On Friday afternoon, 15 November 2024, the conference Corporate Responsibility: Current Issues in the Field of Fundamental Rights & Sustainability will take place.

Exploring metabolomics-based biomarkers for diagnosis and treatment response monitoring of community-acquired pneumonia

The recent rise in global migration movements and the simultaneous attempts to prevent migrations to the Global North in general and Europe in particular have produced numerous images and narratives that try to record and convey these events and their actors.

What Accounts for the Variety of National Policy Responses to the COVID-19 Pandemic in Europe?

The research conducted at the Leiden Academic Centre for Drug Research is clustered within the divisions of BioTherapeutics, Cell Systems and Drug Safety, Medicinal Chemistry and Systems Pharmacology and Pharmacy, and the Metabolomics and Analytics Centre.

Searching for ways to delay the need for a transplant and trying to build kidneys to order.

How do pathogenic mycobacteria alter lipid metabolism in human cells and patients, and which disrupted pathways could be targeted for new antibiotics?

Since Russia’s invasion of Ukraine in February 2022, the European Union (EU) and its Member States have adopted wide-ranging legal and political measures to support Ukraine in its struggle.

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics.

PhD defence

A major goal of ABS research is to overcome one of the major bottle-necks in metabolomic research: the lack of a high-throughput infrastructure in which thousands of samples can be processed in a standardized and cost-effective way (max. a few tens of Euro’s per sample for a full metabolome profile).…

Would you like to know more about our research using laboratory animals or our studies on alternatives to animal testing? If so, take a look at the news articles on the right-hand side of the page (for mobile users, see the bottom of the page).

Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

How are the epidermal lipid pathways involved in health and disease.

Promotor: Prof.dr. B. van de Water, Co-promotor: L.S. Price

Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.

Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

Advanced UHF MRI techniques provide powerful tools for studying the zebrafish brain, an emerging model in neurological research. In this work, various MRI and localized MRS methods are optimized and employed for UHF strength for studying the zebrafish brain.

Our research aims to develop drugs that boost the host immune response to better defend us against mycobacteria.

On 17 December 2018, Dejian Kong defended his thesis 'Civil Liability for Damage caused by Global Navigation Satellite System'. The doctoral research was supervised by Prof. dr. P.M.J. Mendes de Leon.

Key publications of the Skin Barrier and Vaccination group.

PURPOSE: To monitor the biodistribution of IgG1 aggregates upon subcutaneous (SC) and intravenous (IV) administration in mice and measure their propensity to stimulate an early immune response.

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

This thesis investigates a pharmacological challenge model induced by Toll-like receptor 7 (TLR7) activation, focusing on skin inflammation and its implications for early drug development.

Proteases degrade matrix molecules in the atherosclerotic plaque, thereby reducing atherosclerotic plaque stability. Mast cells, that contain proteases such as tryptase and chymase, have been identified at the site of rupture in specimens of human coronary arteries and their number in the plaque was…

This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…

This work has described synthetic strategies towards well-defined structures resembling capsular polysaccharide (CPS) fragments, CPS mimics, teichoic acid (TA) fragments as well as a third-generation ring-closing tandem metathesis (RCM) linker to better exploit the potential of automated synthesis.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

Bet v1, the major allergen in birch pollen, is one of the main causes of allergies such as asthma and rhino-conjunctivitis. Additionally it is the main cause of birch pollen allergy in humans.

On 9 April 2019, Yudan Tan defended her thesis 'The Rome Statute as Evidence of Customary International Law'. The doctoral research was supervised by Prof. dr. W.A. Schabas.

Can we link multiple components from herbal extracts with their biological activities?

A main goal of MSBB research is to address the major bottle-necks in combatting viral diseases: the lack of experimental models that are representative of human pathology and are cost effective and versatile. Viral diseases such as those that cause viral hemorrhagic syndromes or severe acute respiratory…

The symposium is open to all registered participants and consists of a one-day programme and a poster session.