Researchers at the Leiden University Medical Centre (LUMC) have managed to culture human heart muscle cells on a massive scale. This is an exceptional achievement because it is very difficult to replicate heart muscle cells outside the body. Using a special technique, the researchers have now created…

During illness, the stiffness or viscosity of cells can change. Tom Evers demonstrated this by measuring such properties of human immune cells for the first time. ‘The stiffness of certain cells could be a way to make a diagnosis,’ Evers said. He defended his thesis on March 26th.

The promising early results of an international study have shown that insulin-producing cells grown from stem cells can cure the disease. The new Cure One LUMC research centre aims to accelerate this breakthrough.

Researchers at the Faculty of Science work at the frontiers of knowledge every day, tackling today’s major societal challenges. Their work is recognised through grants, prizes and other awards. We highlight some of these achievements below.

What if you could watch a single cell eat in real time? This could answer questions about diseases such as cancer. PhD candidate Yixuan Wang has developed a glowing chemical tool that makes this possible, revealing how living cells take in nutrients.

Bacteria temporarily live without their cell wall if dangerous viruses are near. A remarkable feature, as the cell wall is a sturdy barrier against threats. Still, the discovery has a logical explanation ánd might be of a consequence for fighting pathogenic bacteria, according to Véronique Ongenae,…

A COVID-19 vaccine that specifically instructs the immune system to produce T-cells rather than antibodies is shown to provide good protection in a mouse model, Leiden University Medical Center (LUMC) researchers report in Nature Communications. According to them, the alternative vaccine may offer a…

Cells in our bodies are often threatened by errors in our own proteins. The FLOW consortium, comprising scientists from various institutions including Leiden, is poised to meticulously map out for the first time how cells control proteins, correcting or removing faulty ones. This endeavour holds promise…

About forty microscopes, various laboratories, and some 15,000 zebrafish: that’s Sylvia le Dévédec's workplace. She is one of the managers of the Leiden Cell Observatory, a unique facility accessible to all researchers.

What’s really happening in the space between the cells in your body? With the Collagen Canvas project, students from Leiden University invite you to explore this question by blending science with art. This interactive artwork immerses you in the dynamics of the extracellular matrix—the invisible structure…

For the first time, it was shown in living cells how the bacterium E. coli regulates genes that help it survive in a new environment. Biochemist Fatema Zahra Rashid managed to do this using a technique she fine-tuned. Her research into changes in 3-dimensional chromosome structure offers clues for ways…

At the division of BioTherapeutics, Amanda Foks, Bram Slütter and Ilze Bot have obtained a €4 million research grant from the HORIZON 2022 EIC Pathfinder Challenge “Cardiogenomics”, entitled “B-specific: B-cell related gene and protein markers with prognostic and therapeutic value for CVD”.

Destroying proteins from the Golgi apparatus of the cell in a controlled manner. That is the focus of chemist Marta Artola’s pioneering research. By developing a groundbreaking technology to target specific proteins in the Golgi, Artola aims to unlock new ways for drug development. For this ambitious…

A tenacious postdoc researcher persuaded Professor Marc Koper to research the oxygen reduction reaction. In Koper's eyes, there was little of interest there. But they promptly discovered a whole new way to improve fuel cells on hydrogen and oxygen. Their article appeared in Nature Catalysis on 07 Ju…

When you think of physics, do you think only of complicated formulas? You’re not the only one. Therefore, every year, the Leiden Insitute of Physics organises the LION Image Award to show another side of physics: beautiful images about intriguing science. The winner of the 2022 photo competition captured…

It has only recently been discovered that single-celled organisms (bacteria and archaea) also have histones—proteins that structure DNA. Now, Leiden PhD candidate Samuel Schwab has found that the histones in these organisms are much more diverse than previously thought. Schwab and his colleagues describe…

Understanding the behaviour of tiny droplets in our cells could aid the search for new treatments. A team of Leiden researchers has developed a groundbreaking method to study how these droplets transition from liquid to solid. This change plays a role in various diseases, including neurodegenerative…

Het Leids onderzoek naar gedwongen uithuisplaatsingen van kinderen heeft veel stof doen opwaaien. Op een congres bespraken meer dan 250 mensen het onderzoek verder om zo de situatie voor ouders en kinderen in de toekomst te verbeteren.

This summer, one of our BPS-master students, Ramazan Kiliç, will travel to Baltimore to present his research at the annual ARRE Research Symposium, a conference on ASXL-disorders that attracts researchers from all over the world, including the US, Japan, Germany, Ireland and, of course, The Netherlands.…

Four Leiden researchers have been awarded Proof of Concept grants by the ERC. These grants, each worth 150,000 euros, help researchers translate the findings of previous ERC projects into innovative practical applications.

Sander van Kasteren only noticed some small, subtle changes since he was appointed professor on 1 May. Still, he has to get used to the idea, even though he had been working towards the professorship for a few years. ‘I don't quite see myself as a professor yet.'

PhD defence

In a project funded by the John Templeton Foundation to the group of Micha Drukker, scientists will produce stem cells from short and long living understudied species to model cellular and organismal lifespan.

Lecture, LUCL Colloquium - Series '24/'25

PhD defence

Cancer immunotherapy represents a significant breakthrough in cancer treatment. However, tumors have numerous mechanisms by which they evade destruction by the immune system. It is therefore necessary to decipher and reverse these mechanisms in order to improve immunotherapies.

PhD defence

PhD defence

PhD defence

Gijs Zebregts had just graduated from International Studies when he was stricken with acute leukaemia. A stem cell donor brought relief. Now he is going to cycle from Florence to Rotterdam to raise money and awareness for the donor bank.

From 11-13 July 2022, the 10th EMBRN International Mast Cell and Basophil Meeting took place in the Utrecht University Academia Building in Utrecht. During this meeting, novel insights and developments in the field of mast cell and basophil biology in both health and disease were shared.

3 October University has become something of a tradition: a bit of science among the Leidens Ontzet celebrations. During the new and improved edition, the WetenschapsWarenMarkt (Science Market), visitors spoke to researchers about the nitrogen problem, making organs and the city’s connections with A…

No less than four Leiden research teams have been awarded a grant by NWO. On 27 July NWO honoured 21 applications in the Open Competition ENW-XL. NWO awards the grants to consortia in the exact and natural sciences who are doing unconnected fundamental research that is 'driven by curiosity'.

Lecture, Tuesday Talk

PhD defence

Collaboration is worthwhile. A joint LUMC and Leiden Law School project has received €142,500 from the Dutch Research Council (NWO). This grant will advance research into the law and ethics of regenerative medicine.

On 1 June 2022, Maarten Kunst, Professor of Criminology at Leiden Law School, gave a lecture on his research into the effects of the right to be heard on both the defendant and the victim. Victims have certain rights in the Dutch criminal process, including the right to be heard in criminal proceedings.…

PhD defence

LUMC and Leiden University will start the new two-year online master's program in Transfusion Medicine and Cellular and Tissue Therapies from October 2023.

Nano-plastics cause malformations. Meiru Wang, researcher at the Institute of Biology Leiden, looked at the extreme effects polystyrene nano-particles could have, using chicken embryos as a model. Her results were quite alarming. Especially as nano-particles are everywhere. In the air, floating through…

Leiden University has awarded its prestigious University Medal to Emeritus Professor Lex van der Eb. As a pioneer in genetics and molecular biology, he received this honour for his services to science and his key role in the development of the Leiden Bio Science Park (LBSP).

At our faculty, a great deal is happening in the area of educational development and innovation. We frequently participate in pilots and interfaculty collaborations, and many projects also emerge within our programmes thanks to the expertise and enthusiasm of our teachers. Do you have an idea of your…

Leiden University has selected 13 shared transferable skills that are important for all of its students, regardless of what they are studying. As a faculty, we (co‑)support lecturers and programmes in integrating these skills into the curriculum.