Throughout all domains of life, from bacteria and archaea to eukaryotes, genomes adopt well-organized three-dimensional structures that can change in space and time to accommodate preferred transcriptional programs for environmental adaptation, the maintenance of cellular identity and differentiation…

The long term goal of the Biophysical Organic Chemistry/SSNMR group, headed by Prof. Huub de Groot, is to reach an understanding of structure, dynamics and functional mechanisms of membrane proteins and self-organized biological assemblies and to translate this knowledge into new concepts for nano-devices,…

The organ in the Great Auditorium in the Academy Building has been played at walk-in concerts and University celebrations since 1998.

The research in the Biosyn group is focused on the design, synthesis and function of the four major types of biomolecules: nucleic acids, carbohydrates, peptides and lipids and hybrid structures thereof. These biomolecules and their derivatives are used in drug discovery and chemical biology, to develop…

Great Auditorium Organ Foundation is a Public Benefit Organisation (Algemeen Nut Beogende Instelling, ANBI)

It has only recently been discovered that single-celled organisms (bacteria and archaea) also have histones—proteins that structure DNA. Now, Leiden PhD candidate Samuel Schwab has found that the histones in these organisms are much more diverse than previously thought. Schwab and his colleagues describe…

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This volume challenges the idea that the development of ‘democracy’ is a story of rise and progress at all. It is rather a story of continuous but never completely satisfying attempts of interpreting the rule of the people.

Promotor: G.R. de Snoo

Laura Heitman is awarded the 2018 EFMC runner-up prize for a Young Medicinal Chemist in Academia

After almost four decades, Leiden and Eindhoven chemists have resolved the discussion about the correct model for the simplest chemical reaction in heterogeneous catalysis, which is essential for fuel cells. Using a unique curved platinum surface, Ludo Juurlink and PhD candidate Richard van Lent from…

Treatment with special stem cells seems to be a good option for suppressing the immune system in organ transplants. Researchers are trying to learn from processes that take place in the human body during pregnancy.

How do leadership behaviour repertoires take shape in public organizations?

Freek Janssen, a PhD-student in the department of Molecular Physiology, has received an award for the best oral presentation during the Young Medicinal Chemist Symposium organised by the European Federation of Medicinal Chemistry (EFMC-YMCS’16). Freek Janssen presented his work on “Development of Highly…

Using photosynthesis to generate energy, or using enzymes to effectively produce biofuel; Leiden chemists Huub de Groot en Hermen Overkleeft have both obtained an NWO TOP funding for their pioneering research. With the money they can take on new PhD students.

He is occupied with the home stretch of his promotion. But in between, there is another challenge: Michael Meijer is going through to the finals of ‘The Smartest Chemist of the Netherlands’. On Tuesday 9 October, he and five others fight for this title during the Evening of Chemistry. ‘I was dragged…

Stars like the sun are born in large molecular clouds existing from gas and dust. During the formation process, the chemical composition of the material can be altered drastically by the changing physical conditions.

Charisma K. Lepcha (PI, Sikkim University), Pradyut Guha (co-PI, Sikkim University), Rajib Sutradhar (co-PI, Christ University Bangalore) and Erik de Maaker (Leiden University) have been awarded a two-year grant of USD 18.000 to conduct research on the impact of ‘green farming’ on the sensitive mountain…

The Leiden Institute of Chemistry (LIC) is to be joined by a further two talented young chemists. Bela Bode and Michele Pavanello have each won a Marie Curie subsidy. Bode will be studying electron transport in photosynthesis and Pavanello will be using computer models to study charge transport in large…

This book explores how physicists, astronomers, chemists, and historians in the late nineteenth and early twentieth centuries employed ‘epistemic virtues’ such as accuracy, objectivity, and intellectual courage. In doing so, it takes the first step in providing an integrated history of the sciences…

Complex Organic Molecules (COMs) have been detected in objects across different stages of stellar evolution.

If you could convert CO2 into building blocks for other molecules with the help of electricity, you could make the chemical industry considerably more sustainable. Leiden chemists have unravelled a fundamental part of this process and applied this knowledge in a real device, as they write in Nature…

Hydrogen peroxide (H2O2) is an important bulk chemical that is used in various industrial processes. More than 95% of the H2O2 used in industry is made via the anthraquinone process during which a large amount of energy is going to waste.

My research focusses on site-specific compositional and performance practices of music for organ and electronics and their musical-spatial values.

Our in-house human skin equivalents contain all stratum corneum (SC) barrier lipid classes, but have a reduced level of free fatty acids (FAs), of which a part is mono-unsaturated. These differences lead to an altered SC lipid organization and thereby a reduced barrier function compared to human skin.…

Growing public backlash against international organizations (IOs) and attacks of national political elites on the rule of law increasingly challenge governance by IOs.

The confinement of molecular catalysts in metal-organic frameworks has the potential to lead to significant improvements in selectivity, long term activity and catalyst stability.

Leiden chemists have developed a new technique with which they can determine the role of kinases – a group of proteins – in a living cell. This technique makes it easier to find new drug targets for diseases such as cancer and rheumatoid arthritis. The team published the findings in the journal Nature…

Halfway through his career alumnus Marc Tijhuis made a radical change: he left the corporate world to join the global battle against waste with the International Solid Waste Association.

Regenerative medicine is a new way of treatment that helps impaired cells, tissues, and organs work well again. We do this by repairing, replacing, or restoring cells, tissues, and organs after damage from illness or injury. This includes treating long-term diseases such as diabetes, kidney diseases,…

Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.

Organic amendments applied to agricultural fields can partially offset our carbon emissions to the atmosphere and improve the resilience of agriculture to the effects of climate change. Driving these benefits, however, are complex and poorly understood interactions between organic amendment properties,…

Understanding how chemical complexity emerges during star formation requires connecting molecular material preserved in interstellar ices with that observed in the gas phase after protostellar heating begins.

The Dick Stufkens Prijs 2010 is awarded to Dr. Niels Elders. The prize is given by the Holland Research School of Molecular Chemistry for his Ph.D. thesis “Multicomponent Approaches to Molecular Diversity & Complexity”, in which he describes the development of various new multi-component synthetic procedures…

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

Chemistry, which is what Hans Klis studied in Leiden, is not what one might expect of a general journalist. ‘I’m a late bloomer,’ he says, despite having spent four years as America correspondent and written a book on notorious school shootings by the tender age of 34.

Professor of Catalysis and Surface Chemistry Marc Koper has been appointed as member of the Koninklijke Nederlandse Akademie van Wetenschappen (KNAW). 'Very honourable, I see this as a confirmation of my work,’ says Koper.

The Future of Multilateralism addresses current challenges and future perspectives of international and regional organizations. It aims to uncover how stable the foundations of global cooperation really are, particularly in the light of the latest unilateral and protectionist practices of international…

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The Dick Stufkens Prize 2020 for the best PhD thesis of the Holland Research School of Molecular Chemistry has been awarded to Dr Mark Koenis. Koenis graduated 21 February with the distinction cum laude on his thesis 'Advanced Spectra Analysis to Determine Complex Structure and Chirality'. He describes…

The central theme of the NWO-project ‘The Promise of Organization’ is the evolution of political organization during the 19th century. We focus on the enthusiasm, arguments and concrete activities of the organizers as well as the criticism offered by opponents of modern political organization.

The close interaction between organic chemi stry and biology goes back to the late 18th century, when the modern natural sciences began to take shape. After synthetic organic chemistry arose as a discipline, organic chemists almost immediately began to pursue the synthesis of naturally occurring compounds,…

Petra van der Bekerom, Joris van der Voet, and Johan Christensen, three assistant professors at Leiden University, conducted a large-scale survey experiment about whether citizens are more negative about failing service delivery than private organizations.

Netherton Syndrome (NTS) is a rare genetic skin disease caused by mutations in the serine protease inhibitor Kazal-type 5 gene, which encodes the lympho-epithelial Kazal-type-related inhibitor. NTS patients have a profound impaired skin barrier function. Because SC lipids play a crucial role in the…