The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

There is considerable need for improved skin models to develop safe and efficient drugs for skin delivery as well as for cosmetic and chemical product testing on the skin.

Our in-house human skin equivalents contain all stratum corneum (SC) barrier lipid classes, but have a reduced level of free fatty acids (FAs), of which a part is mono-unsaturated. These differences lead to an altered SC lipid organization and thereby a reduced barrier function compared to human skin.…

Research in the Lars Jeuken group focusses on redox-active proteins and membranes enzymes, aiming to understand bacterial respiration at the molecular level for the development of antimicrobials and semi-artificial photo-synthetic cells.

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

How can we implement the technique of pharmacological resting-state fMRI to improve the diagnosis of dementia?

Animal models suggest that the chemokine ligand 2/CC-chemokine receptor 2 (CCL2/CCR2) axis plays an important role in the development of inflammatory diseases. However, CCR2 antagonists have failed in clinical trials because of a lack of efficacy.

A main goal of MSBB research is to address the major bottle-necks in combatting viral diseases: the lack of experimental models that are representative of human pathology and are cost effective and versatile. Viral diseases such as those that cause viral hemorrhagic syndromes or severe acute respiratory…

Cardiovascular disease is the leading cause of death worldwide.

Developing robust and comprehensive analytical methods to size and quantify subvisible particles in biopharmaceutical products.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

Human skin equivalents (HSEs) can be a valuable tool to study aspects of human skin, including the skin barrier, or to perform chemical or toxicological screenings.

Within this project, PeptoMiktoStars were realized through an orthogonal protecting group strategy and should be investigated further regarding their potential as drug delivery systems in the field of drug delivery to inflamed areas in cancer, bacterial infections or autoimmune diseases.

Promotor: Prof.dr. T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier

The lipid matrix in the stratum corneum (SC), the upper layer of the skin, plays a critical role in the skin barrier. The matrix consists of ceramides (CERs), cholesterol (CHOL) and free fatty acids (FFAs).

Promotor: Prof.dr. M. Danhof

Structure-affinity relationship (SAR) and structure-kinetics relationship (SKR) studies were combined to investigate a series of biphenyl anthranilic acid agonists for the HCA2 receptor.

Timely, adequate and optimal treatment of infectious diseases is essential for the survival of patients with bacterial infections (Surviving Sepsis campaign).

The barrier function of the skin is primarily provided by the stratum corneum (SC), the outermost layer of the skin. Skin barrier impairment is thought to be a primary factor in the pathogenesis of atopic eczema (AE).

A new research line is the development of liquid biopsy fingerprints to predict early Alzheimer’s disease (AD) stage in human in readily accessible body fluids in human (in collaboration with: Dr. Geert-Jan Groeneveld, CHDR; Prof. Elga de Vries, Free University Medical Center; and others).

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

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Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.

Pancreatic ductal adenocarcinoma (PDAC) is among the cancers with the highest mortality rate, despite a relatively low incidence.

Antimicrobial resistance is one of the biggest threats to human health worldwide in the coming decennia.

Breast cancer (BC) is a clinically and biologically heterogeneous disease.

The Chemical Biology & Immunology (CBI) group is headed by Prof. Sander van Kasteren and Prof. Kim Bonger.

The skin barrier function is provided by the stratum corneum (SC). The lipids in the SC are composed of three lipid classes: ceramides (CERs), cholesterol (CHOL) and free fatty acids (FFAs) which form two crystalline lamellar structures. In the present study, we investigate the effect of CER chain length…

In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.

In vitro disease models play a fundamental role in drug research. They enable the systemic identification and validation of disease mechanisms and the discovery of possible drug targets. However, more than often, drug candidates that are identified in vitro fail in the later clinical stages of drug…

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The objective of the Next Generation ImmunoDermatology project (funding NWO, program NWA-ORC) is to deep profile the immune-mediated inflammatory diseases: i) atopic dermatitis (AD), ii) cutaneous lupus erythematosus (CLE) iii) chronic spontaneous urticaria (CSU) iv) hidradenitis suppurativa (HS) v)…

Chronic inflammatory skin diseases such as psoriasis and atopic dermatitis affect both the physical and psychological well-being of millions of patients, leading to persistent symptoms like itchiness and sleeplessness. These conditions often result in decreased productivity and quality of life overall,…

Pharmacogenetics is nowadays increasingly incorporated in the clinic to better predict pharmacokinetics and optimize dosing regimens of drug treatments. While this approach has been successful and improved our prediction of drug metabolism, drug levels within patients may still commonly deviate between…

No, this isn’t about a Star Wars Alliance that wants to suppress The Resistance. Rather, the EPIC Alliance brings together scientific experts from seven countries to address the growing threat of antibiotic resistance. Leiden professor Nathaniel Martin is part of the 11-member consortium.

On this page you can find information about previous CCLS events.

When a bacterium becomes resistant to one antibiotic, it may sometimes become more sensitive to another. This biological side-effect offers an unexpected opportunity in the fight against antibiotic resistance.

For her bachelor’s thesis, Molecular Science and Technology student Madouc Bergers synthesized her own molecule that can inhibit the breakdown of sugars. Although most students do not even manage to make one building block, Madouc made three. Partly because of this, she has been nominated for the Science…

Methods of treatment for chronic illnesses are limited. Doctors and researchers at Leiden University Medical Center (LUMC) and Leiden University are working on new therapies as an alternative for organ transplants. The goal is to cure the illnesses by restoring organs to their original function. Stem…

This is an Erasmus+ International Credit Mobility project of the Faculty of Science with the Taras Shevchenko National University of Kyiv.

Lecture

From black holes to artificial intelligence and from drug research to data science: welcome to the fascinating world of the Faculty of Science. Our researchers, students and guests regularly give public lectures about their work. You are welcome to attend.

Exploring metabolomics-based biomarkers for diagnosis and treatment response monitoring of community-acquired pneumonia

There are eight institutes at the Faculty of Mathematics and Natural Sciences:

This project is part of the Next Generation ImmunoDermatology (NGID) consortium, which focuses on the comprehensive phenotyping of six different immune-mediated inflammatory skin conditions. A common factor contributing to these diseases is a dysfunctional skin barrier. The skin barrier function is…