The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.

How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?

‘Raising awareness of the disorder is crucial since borderline personality disorder (BPD) still faces considerable stigma ’, says Anne Krause-Utz (Clinical Psychology) . Together with an international team of excellent scientists, Krause-Utz provides an update of current knowledge about this disorder,…

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Investigating neurobiological endophenotypes of Social Anxiety Disorder

As a professor, Natasha Appelman-Dijkstra understands better than anyone how important it is to recognise bone and mineral conditions at an early stage. She emphasises the importance of flexibility and collaboration for better care, groundbreaking research and strong education.

Many primary school children suffer from anxiety and their numbers are increasing. Psychologists from the Knowledge Center Anxiety & Stress (KAS) are developing and researching preventive training.

Stressful events and a lack of support from the environment are both consequences and causes of mood swings in people with a bipolar disorder. This is the finding of PhD research by Leiden clinical psychologist Manja Koenders. PhD defence 7 April.

Leiden researchers have found clues to why a rare pregnancy disorder is mild in some babies but life-threatening in others. Their discovery opens the door to a test that could identify severe cases during pregnancy. Fortunately, a treatment already exists.

Do general practitioners recognize children with or at risk of problematic anxiety and is there a pattern that might help differentiate those with and without anxiety disorders in general practice?

Only one in five young people with emotional health problems such as an anxiety disorder receives appropriate professional help. GPs often fail to properly recognise the signals in children and young people, according to psychologist Semiha Aydin. How can we improve this? PhD defence 23 February.

Professor of Human Genetics Willeke van Roon will give her inaugural lecture on Monday 28 March entitled: ‘Translational research, where small parts make the bigger picture.’ She will emphasise how university medical centres should take responsibility for finding treatments for very rare diseases.

Children with autism spectrum disorder experience serious challenges in social functioning, which threatens their development in many areas of functioning.

Bringing your drug candidates to patients is what many academic chemists dream about, but the road to this goal is long and bumpy. Now, Leiden small molecule nizubaglustat is ready for phase 3 clinical trials. This is thanks to a €132 million funding secured by the biotech spin-out Azafaros.

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Disruption to the gut flora can affect your mental health. How could this knowledge be used to prevent stress-related disorders? This is what psychologist Laura Steenbergen will investigate with the aid of a project grant from the Leiden University Fund (LUF) and the Gratama Foundation.

The use of the pill, in combination with genetic factors, can influence experimental psychological research in women. More research is needed into the influence of the pill on mood disorders, concludes psychologist Daniëlle Hamstra. PhD defence on 30 September.

An international mega-analysis on the neurobiological link between inhibited temperament and social anxiety disorder

Psychologist Bernou Melisse was shocked at the long waiting lists in the Netherlands for people with binge-eating disorders. The problem was not yet on the map in Saudi Arabia. She therefore decided to study how people suffering from binge eating can be helped better in their own region of the world.…

To get a feeling of how we operate at LED3 when it comes to Early Drug Discovery, please browse through our case studies. When you select a case study you’ll find relevant contacts.

In a recent study, Dr. Moji Aghajani and colleagues show that adolescents with a severe form of Conduct Disorder (CD) -with limited prosocial emotions- require an unusually large amount of brain capacity to read emotional faces. These effects were found in comparison to CD youth without limited prosocial…

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The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

Disinformation has become a popular subject of study and debate. A plethora of publications and policies have emerged, aiming to analyse and curb the negative consequences of unwanted communication.

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

On October 20 and 21, 2016, Leiden University will host an international conference under the title

This project has two main aims: I. Determine when novelty promotes fear extinction. II. Discover the neurobiological mechanisms underlying these effects.

Teacher Dr. Elke Devroe introduces group role-play on actual themes of governance of crime and social disorder. In the final session of the course, the classroom was transformed into a theatric scene where students applied their insight into the contemporary debates on various issues in governance…

If you know a crime is about to occur, should you be able to prevent it before it has even happened? This was one of the questions that was posed in light of predictive policing as a form of mass surveillance during the debate in the elective Governance of Crime and Social Disorder class of the Crisis…

What is the role of stress and stress-related hormones in emotion regulation?

Delineating psychophysiological endophenotypes of social anxiety disorder