The Directorate-General Police, Sanctions, and Protection has initiated this research project in order to gain insight in the nature and, if possible, the extent of the developments with regards to the pluralization of policing functions in the Netherlands in support of future policies for the benefit…

Professor Jenny Doetjes at Leiden University researches similarities and differences in languages, specifically in the area of numerals and quantifiers. Her research provides insight into language patterns, bu also in the working of the human brain. Inaugural lecture on 26 January.

On June 10, Michelle Achterberg received the prize for best dissertation from the Dutch Neurofederation, the network of Dutch neuroscientists, for her thesis 'Like me, ore else...'. Achterberg obtained her doctorate cum laude from the Gravitation Program 'Samen Uniek' of the Leiden Consortium on Individual…

During the course of drug discovery translational steps are made.

In Chapter 1 we provide some background information about modular forms, describe the correspondence between half-integral and integer weight modular forms and explain how the coefficients of half-integral weight modular forms encode the central values of L-functions of twisted modular forms.

Ilze Bot and Johan Kuiper have published in The Lancet: Study unveils how stress may increase risk of heart disease and stroke. Aso: The National Dutch newspaper 'NRC' has mentioned them in a column

Regular users of cannabis are less aware of their own mistakes, and they are not good at creative thinking. This is the conclusion drawn by psychologist Mikael Kowal from his research on the effects of cannabis. PhD defence 6 October.

Over a period of seven years, researchers from the International Brain Laboratory mapped 279 brain regions at the cellular level. Their findings are now published in Nature, with both data and software openly shared. Cognitive neuroscientist Anne Urai: 'Any researcher with a good question can make use…

In a new video series for the Corpus Kids Academy, researchers Marieke Bos and Janna Marie Bas-Hoogendam explain how the adolescent brain develops and how anxiety works. 'We wanted to present the information simply, while still preserving the complexity.'

Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang

We will study how inoculation of former arable land with soil (including the microbiome, soil fauna and seeds/rhizomes of ground flora) from old forests along with planting targeted tree species mixtures will improve productivity and more rapidly restore forest-adapted communities and ulttimately result…

Promotor: J.M. van Ruitenbeek, Co-Promotor: S.J. van der Molen

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

OBJECTIVES: To determine whether the lipid/protein ratio and the total dry SC mass per surface area are related with the skin barrier function of controls and AE patients.

An important feature of atopic eczema (AE) is a decreased skin barrier function. The stratum corneum (SC) lipids - comprised of ceramides (CERs), free fatty acids (FFAs) and cholesterol - fulfill a predominant role in the skin barrier function.

The barrier function of the skin is primarily provided by the stratum corneum (SC), the outermost layer of the skin. Skin barrier impairment is thought to be a primary factor in the pathogenesis of atopic eczema (AE).

Eveline Crone wrote a new edition of

Heightened activation of the striatum that adolescents show in response to reward is often associated with risk-taking and negative health consequences. This article in Nature Communications investigates a potential positive side of this heightened activation. It shows that the activity peak in late…

Toll-like receptors (TLRs) are central components of the innate immune system, functioning as pattern recognition receptors that detect microbial- and damage-associated molecular patterns and initiate antimicrobial and inflammatory responses.

Neuroscientist Anne Hafkemeijer is able to distinguish two different forms of dementia using advanced imaging techniques. This is the first step towards early recognition of dementia in patients on the basis of brain networks. PhD defence 26 May.

The brains of adolescents react more strongly to receiving rewards. This can lead to risky behaviour, but research in Leiden has shown that it also has a positive purpose: it makes learning easier. The publication of an article on the research findings led to a lot of media attention.

In a recent mega-analysis, researchers from Leiden University aimed to clarify the contradictory findings of research into social anxiety disorder. They found that to obtain reliable research results having the largest possible sample size is important. Publication in NeuroImage:Clinical.

For their research many neuropsychologists use the brain scanners at the LUMC. At the start of the pandemic, the rules for visiting the hospital became stricter and a large amount of psychology research looked as though it would fall through. Thanks to good protocols the researchers can now pick up…

In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.

During a well-attended Studium Generale lecture at Rijksmuseum Boerhaave, Professor Ellen de Bruijn demonstrated how hormonal fluctuations influence the female brain. 'We urgently need more attention for the mental health of girls and women during transitional periods.'

Does a drug enter into the human brain once administered in the body?

Few researchers see potential in research on glioblastoma, an incurable brain tumour. Alexander Kros brought together colleagues who are up to the challenge. European research funder ERC recently made 10.6 million euros available, a year earlier NWO provided 3 million euros. ‘In six years, we certainly…

We prove a p-adic version of the work by Gross and Zagier on the differences between singular moduli by proving a set of conjectures by Giampietro and Darmon, who investigated the factorisation of a rational invariant associated to a pair of CM-points on a genus zero Shimura curve, obtained as the ratio…

Assuming everywhere good reduction we generalize the class number formula of Taelman to Drinfeld modules over arbitrary coefficient rings.

Promotor: Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar

Jens Iverson, Assistant Professor of International Law and a Researcher in the Jus Post Bellum Project, defended his Ph.D. dissertation on 21 September 2017.

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

The master's specialisation Clinical Neuropsychology consists of three main parts: the mandatory and elective courses, a thesis and an internship.

What are the most important perpetuating factors of chronic fatigue and chronic fatigue syndrome, and which interventions are effective in influencing these factors?

Miranda Smit, Ineke van der Ham and colleagues have published a paper in Experimental Brain Research, entitled: Body ownership and the absence of touch: Approaching the rubber hand in- and outside peri-hand space.

Ferritin is a spherical metalloprotein, capable of storing and releasing iron in a controllable way. It is composed of a protein shell of about 12 nm and within its cavity, iron is stored in a mineral form.

This research will focus on the relationship between the musical structure and musical time in the performance of 19th century music.

Nature, nurture and neural mechanisms of social emotion regulation in childhood

Questionnaires or concentration tasks can be used to screen for anxiety, but so too can EEG recordings – at least indirectly. The frequent mind wandering of anxious people can also be seen on MRI scans. These are just some of the findings of clinical neuropsychologist Dana van Son. PhD defence on 24…

In the specialisation Clinical Neuropsychology, part of the Master in Psychology, you will focus on fostering clinical and scientific skills based on a solid theoretical background as well as practical training in neuropsychology and (clinical) neuropsychological research.

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

Leiden University will appoint Dr Anne-Laura van Harmelen as Professor of Brain, Security and Resilience at the Institute of Education and Child Studies with effect from 1 September 2020. She will focus on the brain in relation to the development of transgressive behaviour and its prevention and tre…

Hoping to learn something about the human brain, Leiden researchers are creating a setup to shoot single photons, particles of light, into someone’s eye. ‘The eye is a passageway to the brain.’

May 12 is Mother's Day in many countries. Becoming a mother is no mean feat: brain scientist Elseline Hoekzema has shown that a woman's brain changes drastically during pregnancy. She explained how in TV show De Kennis van Nu.

Maaike Kempes believes more attention should be paid to non-congenital brain injuries in suspects. This may partly explain their criminal behaviour.

How do fats and enzymes in the brain contribute to multiple sclerosis? In his PhD research, Daan van der Vliet combined chemistry and neuroscience to gain new insights into how brain disorders develop.