For effective cancer immunotherapy by vaccination, co-delivery of tumour antigens and adjuvants to dendritic cells and subsequent activation of antigen-specific cytotoxic T cells (CTLs) is crucial. In this study, a synthetic long peptide (SLP) harbouring the model CTL epitope SIINFEKL was encapsulated…

Promotor: Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar

Late in 2015 a woman gave birth to a baby conceived following the reimplantation of thawed ovarian tissue. The woman was able to become pregnant thanks to transplantation of the tissue that took place in the LUMC.

Veel mensen denken dat zware metalen giftig zijn en mens en natuur altijd schade aanbrengen. Dat beeld moet genuanceerd worden, vindt hoogleraar Sylvestre Bonnet.

Almost two weeks after the general elections in the Netherlands, negotiations between the leaders of the four parties who were expected to form a new coalition government are still not going smoothly. Ronald Plasterk, appointed as ‘scout’ to explore possible alliances, has said he will need one more…

The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.

The development plans for the Humanities Campus are changing somewhat. The financial challenges at the Faculty of Humanities and the higher education cuts mean Leiden University has to reduce its spending. One consequence is the Lipsius building will not be rebuilt after demolition in 2031.

In what way can the qualities of an existing context be used as guiding and enriching principles rather than limiting factors in the process of spatial transformation?

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This article provides an in‐depth assessment of lone actor terrorists’ attack planning and preparation.

This thesis discusses the discovery potential of Intensity Frontier experiments.

PhD defence

With cancer, the immune system is a double-edged sword: it can attack tumour cells, but can also help them grow and spread. It is a question of harnessing it. This is what Professor Karin de Visser argued in her inaugural lecture on 15 November 2019.

Researchers at Leiden University have demonstrated that tumours can apply mechanical means to attract the blood vessels they need to be able to grow. The team published this discovery on 2 March in Nature Scientific Reports.

At the end of October, the Steering Committee, headed by Dean Mark Rutgers, gave the green light for the development of the new Faculty Strategic Plan for 2021-2026. How does this process go?

Leiden University Libraries (UBL) recently issued a new collection policy plan, containing priorities for the coming years regarding the formation, management, availability, and use of the UBL collection.

A new website has been set up that provides information about the government funded Law Sector Plan in the Netherlands, including the plans of the participating universities and developments within the agreed themes.

Valedictory lecture

Now the Dutch national Law Sector Plan has been positively evaluated, the temporary funding provided to Leiden Law School for the research projects ‘Institutions for Conflict Resolution’ and ‘Empirical Legal Studies’ will become structural.

Strengthening a cancer patient's own immune system so that the body itself can better destroy cancer cells. This is at the heart of immunotherapy, the most promising progress in cancer treatment in recent years. In order to drive this development further, the Netherlands Cancer Institute-Antoni van…

Research groups in the Biological & Soft Matter Programme unravel mechanisms in biological processes and develop novel bio-inspired soft materials.

Leiden chemists, together with colleagues at the University of York (UK) and Technion (Israel) have discovered a small, sugar-like molecule that maintains the integrity of tissue around a tumour during cancer. This molecule prevents tumour cells from spreading from the primary cancer site to colonise…

In the research programme Drug Discovery & Safety, we are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar-Jagalska

PhD student Janine Westendorp and her colleagues conducted literature research on what patients with cancer and their loved ones perceive as harmful communication from healthcare providers. The results were published in the journal Psycho-Oncology and are released as a poster to distribute to healthcare…

The research within the Division of Cell Systems and Drug Safety, headed by Prof. Bob van de Water, is focused on novel therapeutic modalities and novel concepts in early drug discovery, in order to develop more effective and safer therapeutic strategies. We generate advanced cell and computational…

Nine Honours Class students pitched their plans on 3 March to make the city of Leiden safer, more transparent and more democratic. In this version of 'Dragons Den' headed by Professor Job Cohen the students were tested on their plans and their mettle.

The Leiden Institute of Physics has been awarded three out of twelve available grants from the FOM Projectruimte. Principal Investigators Milan Allan, Stefan Semrau and Carlo Beenakker all receive around 400,000 euro for their research.

Nausea, neurologic pain and hair loss: some of the severe side effects of chemotherapy. Not necessary, biochemist Liyan Zhang showed. Together with Leiden biologists and others, she achieved great results with a drug that is only active in combination with light. Zhang will defend her PhD on 4 July.

Chemotherapy that does nothing until you irradiate it with light. Sylvestre Bonnet receives a Vici grant of 1.5 million euros for the development of this treatment. The Leiden chemist wants to build a new molecule to fight tumours that are at the time still difficult to treat.

Leiden has a long history in the treatment of blood cell cancer. Research to find better therapies never stands still. One of the potential treatments currently being worked on is a ‘living medicine’.

A month ago it was Marc Baggelaar, and now Hans Kistemaker too has obtained his PhD cum laude at the Leiden Institute for Chemistry (LIC). ‘He has made ground-breaking contributions to the world of protein modification,’ says PhD supervisor Gijs van der Marel. Kistemaker obtained his PhD on 11 May…

A team led by Erik Danen from the Leiden Academic Centre for Drug Research has received a 3 million euros NWO Science Groot grant to unravel the first steps of metastasis. Danen will work together with biologists and theoretical and experimental physicists from Dutch Universities. ‘Understanding these…

Lecture

Treatment and care for cancer patients is becoming increasingly advanced. For example, surgeons can now perform operations with much greater precision, and therapeutic vaccines are being developed to prompt the patient’s immune system to fight cancer. Work is also being done on better early diagnostics,…

Doctors should work with patients with bone and soft-tissue tumours to find the best personal treatment strategy says Prof. Michiel den de Sande. He has developed an app that helps choose the right treatment. Van de Sande was appointed Professor of Orthopaedics with a particular focus on paediatric…

Key publications of the Cancer Drug Target Discovery group

New or improved treatments for chronic and acute illness.

The aim of Plan S – open access in science – is quite right, says the League of European Research Universities (LERU), of which Leiden University is a member. But the proposed implementation plan will cause too much difficulty for researchers and institutes. LERU has therefore come up with ten recommendations…

Discovery of metastasis promoting candidate drug targets

An overview of the research at the Cancer Dug Target Discovery group.

On Friday 20 September, the first Sector Plan Conference for the theme Cultural Heritage and Identity will be organised in Rotterdam. The conference is intended for all staff and national partners working in the field of Cultural Heritage and Identity. In particular, those involved in the Sector Plan…

As of 1 September, the Netherlands has a national action plan to promote diversity and inclusion in teaching and research. The plan was launched at Leiden University’s Wijnhaven building on its Campus The Hague.

Improving health, enhancing well-being and reducing health disparities across society.