Elizabeth Stuart is one the most misrepresented – and underestimated – figures of the seventeenth century. Daughter of James VI & I, she was married to Frederick V, Elector Palatine in 1613 – they were crowned King and Queen of Bohemia in 1619, only to be deposed and exiled to the Dutch Republic in…

Shining a light on the nefarious netherworlds of espionage, this is the first book to concentrate on the actual techniques and technologies used by early modern spies —from ciphers to counterfeiting, invisible inks to assassination

The American Association of Pharmaceutical Scientists (AAPS) has been pleased to announce Dr. Elizabeth de Lange as a recipient of the 2013 AAPS Fellows Award at the 2013 AAPS Annual Meeting and Exposition in San Antonio.

De Franse uitnodiging van president Marcron aan Nederland en zes andere Europese bondgenoten, om te praten over ‘uitgebreide nucleaire samenwerking’, past volgens het internationaal recht binnen het bestaande verdrag uit 1970, zegt Anna Marhold, expert in internationaal recht, in Dagblad Trouw.

Professor of Predictive Pharmacology Elizabeth de Lange has received an Honorary Doctorate from the Faculty of Pharmacy of Uppsala University. She will be honoured during the Uppsala Winter Conferment Ceremony on 31 January 2020.

Twee jaar geleden klaagde promovendus Danny Mekić het socialmediaplatform X aan, omdat zijn account, zonder toelichting, onvindbaar werd gemaakt. Hij kreeg gelijk van de rechter, maar X verzet zich ertegen: ‘Twitter wil niet transparant zijn.’

Landen proberen steeds strengere maatregelen te nemen om minder aantrekkelijk te worden voor asielzoekers. Mark Klaassen, universitair docent vreemdelingenrecht, noemt het Europese asielbeleid in de Volkskrant ‘een race naar beneden.’

Lidstaten negeren steeds vaker gemaakte afspraken wanneer het hen uitkomt, waardoor de grondbeginselen van de VN meer dan ooit onder druk komen te staan. In een recente VN-spoedvergadering hekelde topman Guterres de lidstaten en zei dat ‘het handvest geen menu á la carte is.’ Niels Blokker, emeritus…

Sonja Barend distantieert zich van het toneelstuk Sonja, dat gebaseerd is op haar boek. Dirk Visser, hoogleraar intellectueel eigendomsrecht, gaf uitleg in het AD: ‘De auteurs hebben het recht om te zeggen dat ze niet meer achter de productie staan.’

The Department of Constitutional and Administrative Law of Leiden University is active in education in various ways.

The fact that a significant number of seats in the Dutch provincial councils are now occupied by members of the Dutch Farmer-Citizen Movement (BoerBurgerBeweging, BBB) who have an agricultural background need not lead to conflicts of interest when voting on, for example, nitrogen emissions. This is…

On 6 June 2019, Edward Donelan defended his thesis 'Regulatory Management Policies and a Universal Model for Public Policy Making, Legislative Drafting and Managing Stocks of Legislation'. The doctoral research was supervised by Prof. W.J.M. Voermans.

Meet the people of the Resilience Center

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

The advanced insights obtained for the CNS PBPK model development are currently used to develop advanced mathematical models for drug distribution prediction in other body tissues protected by barriers, such as the gut. The gut PBPK model will be linked to drug effects for treatment of colon cancer.

In 2014 Hans-Martien ten Napel received a Research Fellowship in Legal Studies at the Center of Theological Inquiry in Princeton, NJ. The book he wrote as a result of this fellowship was published last week by Routledge Law.

Voor zowel archeologen, paleontologen en geologen als vrijwilligers in de archeologie en paleontologie is het geen verrassing meer dat op de stranden van de Nederlandse kust fraaie vondsten gedaan kunnen worden. Vele artikelen, boeken, tentoonstellingen, congressen, lezingen, ‘zoekdagen’, krantenberichten,…

Procedural administrative law in a constitutional comparative law perspective

Politically speaking, the Frisian coastal area constitutes a special case in late medieval Europe since it was not subject to an overlord as it withstood feudalization in the 13th century. Its many sub regions, which were dominated by elites of small noblemen and freeholders, long time succeeded in…

Nederland ligt in de periferie van het verhaal van menswording. De evolutie van onze familie vindt lang exclusief in Afrika plaats. En, als Europa eenmaal bewoond wordt door mensachtigen, ligt het zwaartepunt ten zuiden van onze streken. Toch heeft ons land een aantal interessante vindplaatsen en vondsten…

In Migration and Membership Regimes editors Ulbe Bosma, Gijs Kessler and Leo Lucassen bring together ten essays in an analytical framework which looks beyond the Transatlantic migration of the nineteenth and twentieth centuries in a deliberate attempt to incorporate the experience of earlier periods…

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

Another research line is the development of a spatial CNS drug distribution model, by ultimately including the 3-dimensional anatomical organization of the CNS.

The aim of this research area is to be able to predict human drug response on the basis of mathematical models that are developed using preclinical experiments and prior knowledge.

This new volume, published 19 November 2020, - within the series 'Intersections' -, explores the concept of magnificence as a social construction in seventeenth-century Europe. Although this period is often described as the ‘Age of Magnificence’, thus far no attempts have been made to investigate how…

Arie van Steensel and Ariadne Schmidt (eds.)

In een uitzending van het Politiek Café van - Dit is de Dag (NPO) discussieerden staatsrecht-experts Corne Smit en Wim Voermans over de vraag of een minderheidskabinet in Nederland levensvatbaar is. Hun antwoorden liepen uiteen, maar kwamen op hetzelfde neer: stabiliteit.

Uniting an international consortium of scholars, the Skandapurāṇa Project comprises a team of researchers working in fields across the Humanities. We are creating a critical edition of a foundational work of purāṇic literature and, in doing so, tracing the dynamics of a textual tradition to better understand…

Prof. Elizabeth de Lange is concerned with the allocation of resources for the conduct of science towards the goal of best serving the public interest. Also, while she underscores that there is still the need for using animals in drug research, she is concerned about this use, and advocates the use…

On 7 December 2021, Georgina Kuipers defended the thesis 'Beschadigd vertrouwen'. The doctoral research was supervised by Prof. W. den Ouden and Prof. M.A. van der Steen (EUR).

Do objectively correct solutions to ethical dilemmas exist? Or is ethics always a matter of your opinion against my opinion? How do you know what to do? What kind of thing is ethics anyway? Can you be an expert in ethics?

Dit rapport maakt deel uit van het project Receptenboek burgerparticipatie in opdracht van de Rijksdienst voor het Cultureel Erfgoed (RCE) en met steun van het Fonds voor Cultuurparticipatie.

The starting hypothesis of the project is that secrecy is not always inimical to democratic governance as conventional wisdom has it.

NNMT wordt beschouwd als een nieuw potentieel farmacologisch doelwit in de behandeling van een verscheidenheid van kankers, stofwisselingsziekten en andere pathologieën. Het toenemend aantal publicaties waarin de rol van NNMT bij ziekten wordt opgehelderd, heeft op zijn beurt de ontwikkeling van krachtige…

This thesis focuses on enhancing predictions of central nervous system drug exposure using the LeiCNS-PK3.0, a physiologically based pharmacokinetic model.

This research cluster explores processes of cultural creation, reception and transformation within a wide range of societal contexts from the early Middle Ages until c. 1800.

Promotor: Prof.dr. M. Danhof, Co-promotor: E.C.M. de Lange

A new research line is the development of liquid biopsy fingerprints to predict early Alzheimer’s disease (AD) stage in human in readily accessible body fluids in human (in collaboration with: Dr. Geert-Jan Groeneveld, CHDR; Prof. Elga de Vries, Free University Medical Center; and others).

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

The research project examines the site-specific event within the field of installation art and choreographic practices.