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Inaugural lecture

Is the quality of the current supervision and enforcement by the government such that companies that work with large quantities of hazardous substances are brought into compliance with legislation and regulations?

On 9 April 2020, Mohamed Azizi defended his thesis 'Reflecties op Wereldburgerschap: In de spiegel van Afghanistan en Nederland'. The doctoral research was supervised by Prof. P.B. Cliteur en Prof. W. Veugelers (Universiteit voor Humanistiek).

On 14 November 2019 Niek Schipper defended his thesis 'De invloed van de woonplaats op de fiscale behandeling van grensoverschrijdende werknemers'. The doctoral research was supervised by Prof. S.C.W. Douma and Prof. J.P. Boer.

You can find more information on the Dutch webpage. Click on the “Nederlands” button above.

Promotores: Arjen Doelman, Jens Rademacher, Max Rietkerk

We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.

Promotor: Roeland M.H. Merks

The study at hand focuses on the control of sex and youngsters through the response by authorities most notably from within criminal justice.

Schatten uit het oude Armenië

On December 6th, Bob Schoemaker succesfully defended his doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Bob on this great result.

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

Het is een wijdverbreid idee dat (post-)middeleeuwse steden een sterfteoverschot hadden en zij slechts in leven konden blijven door de toestroom van migranten; een fenomeen dat bekend staat als het ‘urban graveyard’-effect. Over details valt te twisten, maar duidelijk is dat de stad en de dood dichter…

Nederland ligt in de periferie van het verhaal van menswording. De evolutie van onze familie vindt lang exclusief in Afrika plaats. En, als Europa eenmaal bewoond wordt door mensachtigen, ligt het zwaartepunt ten zuiden van onze streken. Toch heeft ons land een aantal interessante vindplaatsen en vondsten…

Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.

Mathematical models of software systems enable characterizations, abstractions, simulations, and analysis of complex software during its development.

Promotor: Prof.dr. E. Deprettere

In 2016, Dutch University Medical Centres (UMCs) developed the self-evaluation tool based on the PhD Competence Model. Our partners at Utrecht University are making a digital version of the tool available free of charge for our PhD candidates at Leiden University, including for candidates who are not…

Existing work in probabilistic language modeling can be mostly divided into two categories:

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar-Jagalska

De positie van kunst en kunstenaars in de westerse samenleving

The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

Main challenges in skin vaccination are overcoming the stratum corneum (SC) barrier and targeting the antigen presenting cells (APC) in the epidermis and the dermis.

Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.

This research team is concerned with the measurement and modelling of behaviour, cognition, and unobserved traits (e.g., latent variables, missing data). Central aims include the distillation of a complex set of features into lower-dimensional representations (e.g., factor analysis, IRT), determining…

On 14 May 2020, Pieter Rustenburg defended his thesis 'Een algemene normtheorie toegepast op open normen in het belastingrecht'. The doctoral research was supervised by Prof. A.O. Lubbers and Prof. J.L.M. Gribnau.

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Digitalisering raakt iedereen, maar speelt nauwelijks een rol in verkiezingsdebatten. In een opiniestuk in de Volkskrant pleit Reijer Passchier, universitair docent staatsrecht en hoogleraar digitalisering aan de OU voor politieke urgentie en visie op digitale vraagstukken.

Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.

This dissertation studies the Asymptotics of Bayesian nonparametric inference for Gaussian linear models.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

In this thesis, we study systems of electrons in which strong correlations give rise to emergent exotic physics.

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

An in-depth history of Large Language Models—and what their ubiquity, disruption, and creativity mean from a wider sociopolitical perspective.

Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke

This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

Studies over tien eeuwen leescultuur