Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.

The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.

Promotors: C.A.J. Knibbe, Anthonius de Boer, Co-promotor: M.M.J. van der Vorst

Promotores: C.A.J. Knibbe; J.N. van den Anker, Co-promotores: H.P.A. van Dongen; B. van Ramshorst

Obesity may alter how a person absorbs, distributes, metabolizes or excretes medication. This thesis describes how obesity affects drug levels in the blood for antimicrobial agents, such as ciprofloxacin and fluconazole.

This thesis aims to develop model-based approaches to optimize drug dosing in patients with overweight and (morbid) obesity.

Timely, adequate and optimal treatment of infectious diseases is essential for the survival of patients with bacterial infections (Surviving Sepsis campaign).

Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst

‘The idea that overweight and obesity are the fault of parents and/or the child, is rubbish.' Roxanna Camfferman, who specialises in child and adolescent studies, explains her proposition. Her PhD dissertation is on the role of upbringing in child obesity.

Doctors and pharmacists should take greater account of obesity when dosing medicines. The distribution in the body and the breakdown of a medicine can vary considerably in obese patients. This is stated by clinical pharmacologist Catherijne Knibbe in the Annual Review of Pharmacology and Toxicology.

PhD research recently completed by pharmacologist Margreke Brill shows that morbidly obese patients should be given a different dosage of the drugs Cefazolin and Midazolam. This could also apply to other drugs such as anti-cancer drugs as well as antibiotics and Margreke Brill is advocating a change…

Fungal infections pose a significant threat to individuals with compromised immune systems and despite advancements in diagnosis and treatment, they continue to jeopardize patient’s health.

The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

Key publications of the Quantitative Clinical Pharmacology group

The Quantitative Clinical Pharmacology group is led by Prof. Dr. Catherijne Knibbe. Her research group aims to define how to adjust a drug dose in special patient populations such as (prematurely born) neonates or children, obese individuals or critically ill patients. Through combining the statistical…

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

Knowledge on how to adjust a drug dose in special patient populations such as (prematurely born) neonates or children, obese individuals or critically-ill patients, is not only crucial for novel compounds, but also for existing drugs which are often used in an off-label manner in these special patient…

Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…

PhD defence

Dr. in Biomedical NMR spectroscopy, LUMC, Leiden - The Netherlands

What does it mean to eat healthily and responsibly? This question is gaining a new urgency now that in many countries undernourishment is being overtaken by diseases of affluence, such as obesity, and we are also becoming more aware of the environmental impact of our eating habits. It’s time to take…

LUMC researchers are looking for factors that point to illness at an early stage.

LUMC researchers are looking for factors that point to illness at an early stage.

What are the functions of the endocannabinoid system?

The focus of the Antiviral Pharmacology group led by Anne-Grete Märtson is optimizing antiviral therapy for different viral infections by conducting clinical trials and using innovative computational and dynamic laboratory methodologies.

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

The Pharmacy research group focusses on the development of predictive models to improve clinical drug efficacy and safety. We work on clinical problems that require further mechanistic understanding and strive for ultimate benefit to patients.

PhD defence

Exploring the landscapes of mental health and cardiometabolic research.

The aims of the project are to: further clarify 'inhibition by safety'; explore and describe all possible sagety factors, with a special focus on the primary human safety source: social connectedness; reviewing prolonged stress responses without stressors.

Industrialised countries extract natural resources in the territories of indigenous peoples, and appropriate the knowledge and culture of these peoples. Leiden anthropologists work to protect the rights of indigenous peoples. Their knowledge and advice enable governments to source sustainable produc…

A research into how people eat and drink during their daily routines, and the circumstances under which these activities take place.

The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterise and predict variation in treatment response and enhance translational drug development strategies.

Leiden chemical biologists led by Dr Mario van der Stelt have developed a method to facilitate the search for new drugs. This method has allowed them to take an important first step in the development of a drug against obesity.

On the annual spring meeting of the Dutch Society for Clinical Pharmacology and Biopharmaceutics (NVKFB), Margreke Brill received the TOP Publication Award.

Health is a wonderful gift, both for humans and for society. If we are able to prevent both physical and mental illnesses, we can spare a lot of suffering and fight rising health costs. Social scientists and physicians in Leiden are working closely together to conduct research on the human mental, behavioural…

Chemical biologists from Leiden, led by Dr Mario van der Stelt, have discovered substances that can reduce inflammation processes in the brain. This is a first step in the development of potential medicines for the treatment of brain diseases like Alzheimer's and Parkinson's. Published in Proceedings…

Krekels received both the Thesis Award and the TOP Publication Award for her thesis 'Size does matter: drug glucuronidation in children'. Her research led to a new dosage regimen of morphine for babies and toddlers. Both prizes were awarded during the scientific meeting of the NVKFB on Friday 11 Apr…

Children, cardiac surgery patients or people who are obese. How can we improve the dosing of painkillers for these patients? Hospital pharmacist Sjoerd de Hoogd of the St. Antonius Hospital in Utrecht investigated this. He combined data from the hospital with the knowledge and expertise of the Leiden…

On Saturday 17 September Leiden will once again be the setting of the Night of Art and Knowledge. Come along and enjoy a fascinating mix of knowledge, theatre, music and art in the museums and academic locations such as the Hortus botanicus. Tickets are now on sale.

Andrea Evers has received an NWO research talent grant with Jelle van Leusden as the PhD candidate. This grant enables them to start a research project to examine whether automatically regulated responses, such as the circadian rhythm, can be conditioned during sleep.

Not one but two openings: the minister who defended her plans and many who emphasised the importance of standing together with the arts and social sciences: the opening of academic year 2019-2020 in Leiden was not without event.

There are many complex links in the chain that provides patients with new drugs: from fundamental science, to clinical tests, to production. The entire chain can be found in Leiden. Leiden University, the Leiden University Medical Center (LUMC) and the businesses at the Leiden Bio Science Park (LBSP)…

Patients who can’t afford medicine. Refugees who need help. Expats who are ill. All alongside research into obesity. Having trained as a doctor, Dennis Mook-Kanamori chose the hard reality of life as a GP together with a job as a researcher at the LUMC.