Promotor: Prof.dr. B. van de Water, Co-promotor: L.S. Price

To improve treatment of breast cancer patients it is important to understand all stages of breast cancer from initiation to in situ disease and progression to invasive disease. In this thesis we use intraductal injections of patient derived tissue to model ductal carcinoma in situ and invasive breast…

Lipid formulations have demonstrated strong potential for nucleic acid delivery,particularly with the success of COVID-19 vaccines. Despite these advances, manyaspects of lipid formulations remain unclear.

Systems pharmacology aims to apply techniques from systems biology to pharmacological models.

SDN (Software-Defined Networking) represents a revolutionary approach to network architecture that enables the dynamic and flexible management of network resources through software-based control. This dissertation introduces the idea of SDN and its southbound protocol OpenFlow, then presents the formal…

Are predictive archaeological maps a reliable tool to play an important role in the spatial planning? One of the goals of this project was to develop best practices for the production and application of the models.

In this project, we aim to develop mathematical models to mechanistically and quantitatively predict the dynamics of cellular stress pathway activation and its relation with toxic effects when cells are exposed to various toxicants.

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

Hoe kan de City Deal Kennis Maken bijdragen aan het formuleren van maatschappelijk relevant onderzoek dat de stad in al haar diversiteit centraal stelt? In de stad Leiden zijn burgers momenteel maar in beperkte mate betrokken bij het bepalen van de agenda van de lokale City Deal Kennis Maken. Dit onderzoeksproject…

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

Promotor: M. Danhof, Co-promotores: J. Freijer, A. Yassen

Chemical reactions go hand-in-hand with an energy exchange with the environment in which they take place. Surfaces offer a variety of energy dissipation channels, constituted by the nuclear and electronic degrees of freedom of the atoms at the interface. Aiming at an improved future harvesting of energy,…

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Promotor: Prof.dr. W.J.G.M. Peijnenburg, Co-promotor: Dr. ing. M.G. Vijver

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

ASLU 14

A research agenda

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

Decarbonizing the building stock is critical for realizing the climate-neutral target for the Netherlands.

The Agent Based Modelling for Archaeologists (ABMA) project is dedicated to developing Open Educational Resources (OERs) and accompanying materials for agent-based modelling (ABM) in Archaeology.

In this research project child language phonology is studied from the perspective of a psycholinguistic speech-production model and this model is in turn studied from the perspective of developmental phonology.

Promotor: Prof.dr. J.N. Kok

Classical mathematical models treat space and time as a continuum, while it is sometimes more useful to regard it as granular. Hupkes is studying what this means for a number of important patterns that are often found in computer calculations and in nature.

Dit rapport maakt deel uit van het project Receptenboek burgerparticipatie in opdracht van de Rijksdienst voor het Cultureel Erfgoed (RCE) en met steun van het Fonds voor Cultuurparticipatie.

Source: J Cheminform, Volume 7, Issue 1 (2015)

China wordt steeds assertiever in zijn relaties met andere landen, maar achter dit beeld gaat een opmerkelijk diverse maatschappij en politieke realiteit schuil die tal van aanknopingspunten biedt voor samenwerking en verdere integratie van China in de wereld. In China een gids voor de 21e eeuw past…

How might we include circularity into the models often used in IPCC reporting (in technical language, how can IAMs, dMFA models and CGE models be integrated?) What are possible futures for global resource use and what are the consequences for greenhouse gas emissions in these scenarios?

It is a common technique in global optimization with expensive black-box functions to learn a surrogate-model of the response function from past evaluations and use it to decide on the location of future evaluations.

À La Découverte de la Hollande dans les années 1760-1770 : Pierre Famin, Emmanuel de Croÿ-Solre, François-César Le Tellier, Jean-Marie Roland de la Platière, Gabriel-François Coyer. Textes réunis et présentés par Madeleine van Strien-Chardonneau, Paris, Société française d’étude du dix-huitième siècle,…

Promotor: P.D. Grünwald

Promotor: Prof.dr. F. den Hollander

Lecture

Business Process Model and Notation (BPMN) has become the standard for business processes diagrams.

Following their application to system biological models, control theory techniques have further potential to aid in the understanding and application of quantitative systems pharmacology models.

The project Deconstructing Stability aims to improve reconstructions of late prehistoric landscapes and predictive models for the purpose of archaeological heritage management.